A5019585676- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Kawasaki Disease and Coronary Complications
- Cardiac Arrest and Resuscitation
- Liver Disease and Transplantation
- Sepsis Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Acute Kidney Injury Research
- Transplantation: Methods and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Intensive Care Unit Cognitive Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Central Venous Catheters and Hemodialysis
- Infectious Encephalopathies and Encephalitis
- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
- Drug-Induced Hepatotoxicity and Protection
- Alcoholism and Thiamine Deficiency
- Trauma Management and Diagnosis
- Clinical Nutrition and Gastroenterology
- Renal function and acid-base balance
Icahn School of Medicine at Mount Sinai
2020-2024
Indiana University School of Medicine
2022
Montefiore Medical Center
2022
Indiana University – Purdue University Indianapolis
2022
Children's Hospital at Montefiore
2017-2021
Albert Einstein College of Medicine
2019-2021
AECOM (China)
2021
Mount Sinai Health System
2020
Research Network (United States)
2020
SUNY Downstate Health Sciences University
2018
To describe the clinical manifestations and outcomes of critically ill children with coronavirus disease-19 (COVID-19) in New York City.Retrospective observational study 1 month to 21 years admitted March 14 May 2, 2020, 9 City pediatric intensive care units (PICUs) severe acute respiratory syndrome 2 infection.Of 70 PICUs, median age was 15 (IQR 9, 19) years; 61.4% male; 38.6% Hispanic; 32.9% black; 74.3% comorbidities. Fever (72.9%) cough (71.4%) were common presenting symptoms. Twelve...
Myocardial dysfunction and coronary artery dilation have been reported in the acute setting of severe respiratory syndrome coronavirus disease-2-related multisystem inflammatory children. Through a longitudinal echocardiographic single-center study 15 children, we report short-term outcomes cardiac
In this report, we describe the case of a 5-year-old male with SARS-CoV-2 associated MIS-C progressive respiratory failure and vasoplegic shock requiring extracorporeal support. At presentation, reverse transcription-polymerase chain reaction (RT-PCR) testing for was negative, however, SARS-CoV2 antibody positive. Multiple inflammatory markers cardiac biomarkers were elevated. Echocardiogram demonstrated mildly depressed left ventricular function no coronary anomalies noted. The patient...
This study describes the use of bivalirudin in children on extracorporeal membrane oxygenation (ECMO). Pediatric patients receiving were compared to heparin as anticoagulant ECMO. Data was collected for under 18 years age supported by ECMO from January 2016 December 2019. included demographics, diagnosis, indication, type, and duration, indication use, dose range, activated partial thromboplastin time (aPTT) levels, minor major bleeding, hemolysis, mortality. Forty pediatric received ECMO;...
Bronchopleural fistula (BPF) is a connection between the bronchus and pleural cavity. It associated with high morbidity mortality management of BPF has not been well described in pediatric population. We describe 2-year-old girl who presented fever increased work breathing, found to have atypical hemolytic uremic syndrome Streptococcus necrotizing pneumonia development persistent air leak due bronchopleural fistulas requiring extracorporeal membrane oxygenation (ECMO). Three endobronchial...
There is paucity of data about prevalence pediatric acute respiratory distress syndrome (PARDS) in children with pulmonary contusion (PC). We intend to evaluate PC chest trauma and the association between PARDS.Retrospective review Institutional Trauma Registry for patients trauma.Level 1 center.Age 18 years younger a diagnosis PC.None.Of 1916 trauma, 50 (2.6%) had PC. Patients PARDS lower Glasgow Coma Scale (GCS) score (7 [3-15] vs 15 [15-15], P = .0003), higher Injury Severity (ISS) (29...
Objectives: Acute asthma management has improved significantly across hospitals in the United States due to implementation of standardized care pathways. Management severe acute ICUs is less well studied, and variations may delay escalation and/or deescalation therapies increase length stay. In order standardize our PICU, a nurse- respiratory therapist–driven critical pathway was designed, implemented, tested. Design: Cross-sectional study at baseline followed by pathway. Setting:...
To assess current use of vancomycin for methicillin-resistant Staphylococcus aureus bacteremia, we surveyed adult infectious disease physicians. Most respondents reported personal experience with infections failing to respond despite minimum inhibitory concentration data indicating susceptibility. In a hypothetical case such an infection, most would change daptomycin or without other agents.
OBJECTIVES: We aimed to determine which characteristics and management approaches were associated with postoperative invasive mechanical ventilation (IMV) a prolonged course of IMV in children post liver transplant as well describing the utilization critical care resources. DESIGN: Retrospective, multicenter, cohort study who underwent an isolated transplantation between January 2017 December 2018. SETTING: Twelve U.S., pediatric, centers. PATIENTS: Three hundred thirty admitted ICU....
In this report, we describe the case of a 17-year-old boy with progressive respiratory failure requiring extracorporeal support who met clinical criteria for presumptive diagnosis electronic cigarette or vaping-associated acute lung injury (EVALI), clinical, pathologic, and laboratory evidence hemophagocytic lymphohistiocytosis (HLH) macrophage activation syndrome (MAS). The patient in our report had history tetrahydrocannabinol nicotine use months leading up to his presentation fever,...
Abstract A 22‐month‐old female with high‐risk neuroblastoma completed 5 cycles of chemotherapy then underwent high‐dose autologous stem cell rescue (ASCR). Parenteral nutrition was administered from day +2 following ASCR, as she unable to tolerate nasogastric feeds because grade IV mucositis and vomiting. On +12, developed worsening metabolic acidosis above reportable levels lactic acid. Given the patient's well clinical appearance paucity evidence end‐organ dysfunction on physical...
To describe the incidence of and risk factors for acute kidney injury (AKI) in children with respiratory distress syndrome (ARDS) study effect AKI on patient outcomes.A single-center retrospective study.A tertiary care children's hospital.All patients less than 18 years age who received invasive mechanical ventilation (MV) developed ARDS between July 2010 2013 were included. Acute was defined using p-RIFLE (risk, injury, failure, loss, end-stage renal disease) criteria.None.One hundred...
To determine if anti-Xa testing is associated with improved outcomes for patients <19-years-old on ECMO.
Vascular thromboses (VT) are life-threatening events after pediatric liver transplantation (LT). Single-center studies have identified risk factors for intra-abdominal VT, but large-scale lacking.This multicenter retrospective cohort study of isolated LT recipients assessed pre- and perioperative variables to determine VT anticoagulation-associated bleeding complications.Within seven postoperative days, 31/331 (9.37%) patients developed VT. Open fascia occurred more commonly in with (51.61...
Objective The aim of this study was to evaluate diagnostic practices for suspected community-acquired central nervous system (CNS) infection in an urban pediatric population. Methods This is observational, retrospective single-center review cerebrospinal fluid (CSF) studies children, 1 month 21 years old, evaluated CNS from 2004 2014. Cases nosocomial meningitis were excluded. frequency N -methyl- d -aspartate receptor antibody (NMDAR ab) encephalitis analyzed 2010 Results A total 940 unique...
Abstract Background Bleeding and thrombosis are common extracorporeal membrane oxygenation (ECMO) complications associated with increased mortality. Heparin is the most commonly used ECMO anticoagulant, employed in 94% of cases. Reduced antithrombin III (AT3) levels could decrease heparin effectiveness. Neonates have inherently lower AT3 than adults, pediatric patients on can develop deficiency. One potential approach for deficiency exogenous supplementation. However, there conflicting data...