A5080990405- Renal Diseases and Glomerulopathies
- Virology and Viral Diseases
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Chronic Kidney Disease and Diabetes
- Immune responses and vaccinations
- Colorectal Cancer Surgical Treatments
- SARS-CoV-2 detection and testing
- Dental Research and COVID-19
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Sarcoma Diagnosis and Treatment
- COVID-19 diagnosis using AI
- COVID-19 and healthcare impacts
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Cell Adhesion Molecules Research
- Vasculitis and related conditions
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Ear and Head Tumors
- Urinary and Genital Oncology Studies
Tehran University of Medical Sciences
2016-2024
Imam Khomeini Hospital
2016-2024
University of Tehran
2022
Cancer Institute (WIA)
2016
Colorectal cancer is becoming an increasing concern in the middle-aged population of Iran. This study aimed to compare preliminary results short-course and long-course neoadjuvant chemoradiotherapy treatment for rectal patients.Patients group I received three-dimensional conformational radiotherapy with a dose 25 Gy/5 fractions 1 week plus concurrent XELOX regimen (capecitabine 625 mg/m2 from day 1-5 twice daily oxaliplatin 50 on once daily). Patients II total 50-50.4 Gy/25-28 5 5.5 weeks...
The COVID-19 pandemic has caused significant morbidity and mortality thus far. Considering the historical uses of high-voltage X-ray beams for unresolvable pneumonia, we aimed to assess whether low-dose whole-lung irradiation (WLI) could provide any benefits patients with refractory pneumonia.
Cancer staging is essential in determining patients' prognoses and designing the appropriate treatment strategy. American Joint Committee on has released latest version of system for tongue SCC. However, it interesting to know whether this change addition depth invasion (DOI) extra-nodal extension (ENE) have any influence prognosis.
Angiomyofibroblastoma is a rare and benign tumor that usually involves vulvovaginal area in women of reproductive age early menopause. We report lipomatous angiomyofibroblastoma 55-year-old multigravid woman. This measured 9 cm size contained prominent mature adipose tissue comprised approximately 50% the tumor.
Iranian children were vaccinated with the scheduled two doses of monovalent measles vaccine (mMV) from 1984. In December 2003, a nationwide campaign measles-rubella (MR) immunization was established to vaccinate 5-25 year- old individuals. 2004, mMV replaced measles- mumps- rubella (MMR) vaccine. Despite high vaccination coverage, outbreaks still occur in country. this Study, MR immunity status various age groups, different schedules investigated, and immunologic response seronegative...
The introduction of a self-collection sampling method with less discomfort would be great benefit in reducing the risk medical provider's contamination and patient's acceptance. aim present study was to investigate saliva samples' diagnostic performance for COVID-19 RT-PCR test compared pharyngeal swabs.From individuals referred center presentations compatible who were eligible molecular tests, 80 cases selected. Nasopharyngeal oropharyngeal swabs (placed into same transport tube) along...
The prevalence of COVID-19 and its severity have been observed to be on a lower level in underdeveloped countries with poorer standards hygiene. This disparity may attributed the higher seroprevalence other viral diseases, which can result presence antibodies protective against COVID-19. Two widespread diseases such are infection hepatitis A E viruses (HAV HEV). In present study, we explored relationship between these susceptibility COVID-19.Ninety patients were studied two groups controls...
The prevalence of glomerular diseases, as the leading cause chronic kidney disease, is increasing. Renal biopsy still gold standard for diagnosis most disorders. Data on biopsy-proven diseases in Iran limited and none previously reported studies used electron microscopic (EM) evaluation diagnosis. This study was conducted to analyze a referral center Iran.The reports samples from 2006 2018 referred pathology center, affiliated with Tehran University Medical Sciences were reviewed. different...
Mesonephric adenocarcinoma of the uterine cervix, an extremely rare tumor female genital tract, derives from remnants embryonic mesonephric ducts and its prognosis, diagnosis treatment is rather challenging. We report a case 46-year-old woman with history abnormal bleeding enlarged cervix on physical examination without obvious mass lesion. She was clinically underdiagnosed cervical myoma hyperplasia. After simple hysterectomy, stage IB2 diagnosed. Despite adjuvant chemoradiation, she...
Background: Microsatellite instability, the main genetic element in HNPCC syndrome, is associated with a number of cancers, including ovarian epithelial carcinomas. These cancers have distinct characteristics compared to non-MSI related ones. Objectives: The present study aims at determining prevalence microsatellite instability carcinomas and their factors Iranian patients. Methods: Paraffin-embedded blocks, belonging 37 patients definite diagnosis were retrieved from archives. After DNA...
Introduction: Basaloid squamous cell carcinoma (BSCC) of the cervix is an uncommon tumor in female genital tract. The aggressive clinical behavior makes this entity distinguished from other SCC subtypes. Case Presentation: We described a case basaloid uterine 62-year old woman with previous subtotal hysterectomy. Clinical and radiologic examination suggested 3 cm mass cervical stump involving left parametrium. She underwent trachelectomy lymph node dissection followed by adjuvant...
Iran is located in the esophageal cancer geographical belt. As multiple genetic alterations are responsible for molecular pathogenesis of squamous cell (ESCC), role and frequency HER2 expression, MMR deficiency, PI3KCA mutation not well defined.We carried out HER2/neu dMMR/MSI high, analysis specimens patients with ESCC. We accessed archival tissue blocks related to 68 ESCC cases at time surgery following neoadjuvant chemoradiation. These underwent during 2013-2018 Cancer Institute...
Background: Patients undergoing orthopedic surgery are at risk of nosocomial infections, and antibiotic resistance is known to increase the such infections. Objectives: We aimed determine rate in patients admitted wards one largest referral hospitals Iran. also ascertained responsible antibiotic-resistant microorganisms with bone joint Methods: The present cross-sectional investigation was concluded over a period five years, from March 2018 February 2023, great hospital Tehran. Laboratory...
Antibiotic resistance, especially in the form of multidrug-resistant (MDR), is a big problem, intensive care units (ICUs). This study aimed to evaluate antibiotic resistance and MDR patterns among patients hospitalized ICUs one large referral centers Iran.The present was conducted at Imam Khomeini Hospital Tehran (a great hospital), which admits critically ill requiring ICU services. To determine rate positive cultures for resistant strains, patient's blood specimens were sent laboratory...
Data about the prevalence of biopsy-proven kidney diseases in Iran are rare, and none previous studies used electron microscopy for diagnosis. This study aimed to analyze Iran's primary referral center. To best our knowledge, this is most extensive carried out Iran. Reports biopsy samples from patients referred center 2007–2018 were reviewed demographic data, clinical presentation, final Statistical analyses performed. Among 3455 received, 2975 analyzed. Nephrotic syndrome (39%) was common...
COVID-19 reverse transcription-polymerase chain reaction (RT-PCR) has been a reference test for diagnosing disease since the very beginning of pandemic. serology tests have also developed and used to estimate prevalence individuals who already infected. We aimed evaluate performance diagnosis patients had referred medical centers with acute symptoms.
<title>Abstract</title> <bold>Background</bold> Expression evaluation of specific markers PAX8 and CD44 on kidney podocyte cells or their progenitor can be very helpful in diagnosing differentiating between types podocytopathies. In present study, the positivity immunohistochemical parietal epithelial (PECs) was evaluated to diagnose suspected cases Focal Segmental Glomerulosclerosis (FSGS) differentiate it from minimal change disease (MCD). <bold>Methods</bold> This cross-sectional study...
Introduction: C4d is an activation product of lectin pathway complement. Glomerular deposition associated with poor prognosis in different types immune-related glomerulonephritis. The present study was conducted to investigate expression level and its staining pattern renal biopsy patients focal segmental glomerulosclerosis (FSGS) minimal change disease (MCD) by immunohistochemistry method. Materials methods: In this retrospective cross-sectional study, specimens from 46 samples MCD, 47...
Hereditary nephritis (HN), including Alport syndrome (AS) and thin basement membrane nephropathy (TBMN), is a rare genetic cause of hematuria. A definitive diagnosis requires electron microscopy (EM). Therefore, the clinical characteristics these conditions are less known. This study aimed to determine percentage clinicopathological features HN in patients from referral center Iran.
<title>Abstract</title> Background/Aim: Current approaches for locally advanced rectal cancer (LARC) typically recommend neoadjuvant chemoradiotherapy (nCRT) with 5-fluorouracil (5FU) or its oral analogs followed by surgery as the standard of care. However, question whether intensifying concurrent chemotherapy adding oxaliplatin to 5FU-based backbone can yield better outcomes remains unresolved. This study aimed investigate benefits incorporating into fluoropyrimidine-based (CRT) increase...
Background & objective: The incidence of various tumors is strongly influenced by racial characteristics, and therefore the distribution benign malignant lesions follows different epidemiological pathophysiological patterns in societies. This study aimed to evaluate trend primary bone Iranian population. Methods: In this cross-sectional study, pathological information related cases registered data registry pathology laboratory Imam Khomeini Complex hospital Iran between 2017 2022 were...
Abstract Background/Aim Current approaches for locally advanced rectal cancer (LARC) typically recommend neoadjuvant chemoradiotherapy (nCRT) with 5-fluorouracil (5FU) or its oral analogs followed by surgery as the standard of care. However, question whether intensifying concurrent chemotherapy adding oxaliplatin to 5FU-based backbone can yield better outcomes remains unresolved. This study aimed investigate benefits incorporating into fluoropyrimidine-based (CRT) increase locoregional...