A5031672496- Synthesis and biological activity
- Synthesis and Reactivity of Heterocycles
- Synthesis and Biological Evaluation
- Chemical synthesis and pharmacological studies
- Synthesis and Characterization of Pyrroles
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bioactive Compounds and Antitumor Agents
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer therapeutics and mechanisms
- Synthesis and pharmacology of benzodiazepine derivatives
- Analytical Chemistry and Chromatography
- Biochemical and Molecular Research
- Pharmacogenetics and Drug Metabolism
- Synthesis of Organic Compounds
- Protein Interaction Studies and Fluorescence Analysis
- Chemical synthesis and alkaloids
- Chemical Reaction Mechanisms
- Analytical Methods in Pharmaceuticals
- Phytochemical compounds biological activities
Wroclaw Medical University
2004-2023
National Institute of Standards and Technology
2023
Université de Lorraine
2023
University of Wrocław
2003-2004
In the present study, we characterize biological activity of a newly designed and synthesized series 15 compounds 2-[2-hydroxy-3-(4-substituted-1-piperazinyl)propyl] derivatives pyrrolo[3,4-c]pyrrole 3a-3o. The were obtained with good yields scaffold 2a-2c secondary amines in C2H5OH. chemical structures characterized by 1H-NMR, 13C-NMR, FT-IR, MS. All new investigated for their potencies to inhibit three enzymes, i.e., COX-1, COX-2, LOX, colorimetric inhibitor screening assay. order analyze...
Secure and efficient treatment of diverse pain inflammatory disorders is continually challenging. Although NSAIDs other painkillers are well-known commonly available, they sometimes insufficient can cause dangerous adverse effects. As yet reported, derivatives pyrrolo[3,4-d]pyridazinone potent COX-2 inhibitors with a COX-2/COX-1 selectivity index better than meloxicam. Considering that N-acylhydrazone (NAH) moiety privileged structure occurring in many promising drug candidates, we decided...
In the present paper, we describe biological activity of newly designed and synthesized series N-substituted 3,4-pyrroledicarboximides 2a–2p. The compounds 2a–2p were obtained in good yields by one-pot, three-component condensation pyrrolo[3,4-c]pyrrole scaffold (1a–c) with secondary amines an excess formaldehyde solution C2H5OH. structural properties characterized 1H NMR, 13C NMR FT-IR, MS, elemental analysis. Moreover, single crystal X-ray diffraction has been recorded for compound 2h....
The structure of 4,6-dimethyl-5-was determine by X-ray crystallography.The compound crystallized in a monoclinic crystal system and was characterized thus: C2/c, = 27.741(3),b 9.890(2), c 17.904(3)Å, β 103.47(2)°,Z 8, V 4777.0(14)Å 3.The solved direct methods refined full-matrix least-squares on F 2 to final values R1 0.0665 (I > 2σ(I)) wR2 0.1820 (all data).
C21H19N3O2, orthorhombic, Pndl\ (No. 33), a = 8.385(1) Â, b 23.223(2)Á, c 8.8285(9) À, V= 1719.0Â 3 ,Z 4, flgt(F) 0.046, wR Tei (F 2 ) 0.089, T= 100 K. Source of materialA mixture pyrrolopyridazinone (1.09 g), K2CO3 (0.6 g) and ICH3 (0.8 ml) in 40 ml acetonitrile was stirred at 313 Κ for 15 hours.After reaction the filtered filtrate evaporated.The residue chromatographed [CC, ethyl acetate/cyclohexane (2:1:5)].The fractions containing two products: A with Rf 0.89 yielded 0.51 g (mp 577 K) Β...
Abstract Novel pyrrolo[3,4‐d]pyridazinones (III) and (VII) are tested as potential analgesic agents.
Despite the widespread and easy access to NSAIDs, effective safe treatment of various inflammatory disorders is still a serious challenge because severe adverse effects distinctive these drugs. The Mannich base derivatives pyrrolo[3,4-c]pyrrole are potent, preferential COX-2 inhibitors with COX-2/COX-1 inhibitory ratio better than meloxicam. Therefore, we chose six most promising molecules subjected them further in-depth research. current study presents extensive biological, spectroscopic in...
Abstract For see ChemInform in Full Text.