A5089708747- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Hormonal and reproductive studies
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Pregnancy-related medical research
- Carcinogens and Genotoxicity Assessment
- Endometrial and Cervical Cancer Treatments
- Health and Medical Studies
- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Reproductive System and Pregnancy
- Complementary and Alternative Medicine Studies
- Glutathione Transferases and Polymorphisms
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Immune Response and Inflammation
- Phytoestrogen effects and research
- Proteoglycans and glycosaminoglycans research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Animal Genetics and Reproduction
- Nerve injury and regeneration
- Phytochemicals and Medicinal Plants
- Hops Chemistry and Applications
National Cancer Institute
2012-2025
National Kidney Foundation
2023
Heartlands Hospital
2022
Universität Hamburg
2020
University Medical Center Hamburg-Eppendorf
2020
National Center for Complementary and Integrative Health
2004-2017
National Institutes of Health
2003-2017
Charité - Universitätsmedizin Berlin
2010-2013
Freie Universität Berlin
2011-2013
Franklin University
2012
Abstract Lineage plasticity has emerged as an important mechanism of treatment resistance in prostate cancer. Treatment-refractory cancers are increasingly associated with loss luminal markers, and many cases induction developmental programs, stem cell–like phenotypes, neuroendocrine/neuronal features. Clinically, lineage may manifest low PSA progression, to androgen receptor (AR) pathway inhibitors, sometimes small cell/neuroendocrine pathologic features observed on metastatic biopsy. This...
The regulation of epithelial cell function and morphogenesis by the paracrine effectors from mesenchyme or stroma has been well established using in-vivo studies. A more complete understanding these relationships delayed due, in part, to a lack appropriate co-culture models. In this study, we describe model which demonstrates that normal can be reconstituted vitro human endometrial stromal cells regulate both growth differentiation primary cells. Interesting differences proliferation were...
Serum levels of the adrenal androgen dehydroepiandrosterone (DHEA) peak in men and women third decade life decrease progressively with age. Increasing numbers middle-aged older individuals consume over-the-counter preparations DHEA, hoping it will retard aging by increasing muscle bone mass strength, decreasing fat, improving immunologic neurobehavioral functions. Because DHEA can serve as a precursor to more potent androgens estrogens, like testosterone (T), dihydrotestosterone (DHT),...
BACKGROUND Prostatic cancer cells are lethal because they acquire the ability to activate survival pathways that do not require androgenic stimulation. As a rational approach developing effective therapy for these devastating cells, specific signal transduction uniquely required of nonandrogen-dependent prostate must be identified. Previous studies suggested neurotrophin/trk axis may regulate such unique pathways. In present study, changes in expression neurotrophins (NGF, BDNF, and NT-3)...
Prostatic cancer cells are lethal because they acquire the ability to activate survival pathways that do not require androgenic stimulation. As a rational approach developing effective therapy for these devastating cells, specific signal transduction uniquely required of nonandrogen-dependent prostate must be identified. Previous studies suggested neurotrophin/trk axis may regulate such unique pathways. In present study, changes in expression neurotrophins (NGF, BDNF, and NT-3) their cognate...
Prostate stromal and epithelial cell communication is important in prostate functioning cancer development. Primary human cells from normal (PRSC) maintain a smooth muscle phenotype, whereas those (6S) display reactive fibroblastic characteristics. Dihydrotestosterone (DHT) stimulates insulin-like growth factor-I (IGF-I) production by 6S but not PSRC cells. Effects of versus stroma on (NPE or PREC) are poorly understood. We co-cultured NPE plus PRSC to compare influences different...
Abstract Background The survival rate is poor in breast cancer patients with brain metastases. Thus, new concepts for therapeutic approaches are required. During metastasis, the cytoskeleton of cells highly dynamic and therefore cytoskeleton-associated proteins interesting targets tumour therapy. Methods Screening genes showing a significant correlation metastasis formation was performed based on microarray data from long-term follow up information. Validation most target by MTT-, Scratch-...
A panel of expression markers was validated and used to document that, when radical prostatectomy specimens are cultured in low (i.e., <260 micromol/L)-calcium (Ca2+)-serum-free, growth factor-defined (SFD) medium, what grows out not prostatic cancer cells but basally derived normal transit-amplifying epithelial cells. The selective outgrowth the versus is due differential effect low-Ca2+ medium on structure Notch-1 E-cadherin signaling molecules. In receptor conformationally a...
Prostate cancer is one of the four most common cancers in United States, affecting six men. Increased serum levels androgens and IGF-I are associated with an augmented risk prostate cancer. Dihydrotestosterone (DHT) testosterone (T) stimulate cell growth, development, function, whereas effects DHT T stromal cells, dehydroepiandrosterone (DHEA) or uncertain. We investigated actions DHT, T, DHEA, estradiol (E2) on insulin-like growth factor (IGF)-I, IGF-II, receptor (R), IGF-binding protein...
<b><i>Objectives:</i></b> An imbalance in the ratio of sensory to sympathetic nerve fibre (NF) density peritoneal endometriotic lesions (pEL) has recently been demonstrated and leads assumption that this preponderance pro-inflammatory milieu is a major cause pain endometriosis. Therefore, NFs was determined distal unaffected peritoneum endometriosis patients be able detect possible alterations peritoneum. <b><i>Methods:</i></b> In serial pEL...
Abstract BACKGROUND Dehydroepiandrosterone (DHEA) is an endogenous steroid that metabolized to androgens and/or estrogens in the human prostate. DHEA levels decline with age, and use of supplements retard aging process unproved effectiveness safety. LNCaP LAPC‐4 prostate cancer cells were used determine whether DHEA‐modulated proliferation specific antigen (PSA) production mediated via androgen receptor (AR) ERβ. METHODS Cells treated DHEA, DHT, or E 2 antagonists AR (Casodex®‐bicalutamide)...
Abstract INTRODUCTION: The goal of this study was to understand how Ayurveda, the traditional medicine India, can be incorporated into management patients with cancer in United States (US). Patients often seek Ayurvedic treatments complement conventional care for prevention, reduce symptoms/ toxicity, support recovery, improve quality life, or palliative care. Ayurveda is a whole system personalized approach health incorporating multiple modalities including herbal-natural products, diet,...