A5012576193- Tuberculosis Research and Epidemiology
- Lung Cancer Treatments and Mutations
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Diabetes Management and Education
- Cancer Genomics and Diagnostics
- Epilepsy research and treatment
- Pharmaceutical Practices and Patient Outcomes
- Infectious Diseases and Tuberculosis
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Vitamin C and Antioxidants Research
- Diabetes Management and Research
- Vitamin D Research Studies
- Gut microbiota and health
- Lung Cancer Research Studies
- Natural Antidiabetic Agents Studies
- Diabetes and associated disorders
- Pharmacological Effects and Toxicity Studies
- Thyroid Disorders and Treatments
- Pharmaceutical Economics and Policy
- Hepatitis B Virus Studies
- Marine Invertebrate Physiology and Ecology
Manipal Academy of Higher Education
2019-2025
Walter Sisulu University
2024
Frere Hospital
2024
Dar Al-Shifa Hospital
2016-2018
University of Nebraska at Omaha
1997
Background Single nucleotide polymorphisms (SNPs) in the N-acetyltransferase 2 (NAT2) gene as well several other clinical factors can contribute to elevation of liver function test values tuberculosis (TB) patients receiving antitubercular therapy (ATT).
<ns3:p>Background As lung cancer treatment has progressed, there been an increase in awareness of the short- and long-term adverse effects targeted therapies tyrosine kinase inhibitors, particularly cardiovascular toxicities. Methods The current study assessed potential drug interactions using interaction drug-interaction checkers (IBM Micromedex Drugs.com). Molecular docking was employed to further investigate involvement human ether-à-go-go-related gene (hERG) pregnane X receptor (PXR)...
Isoniazid is primarily metabolized by the arylamine N-acetyltransferase 2 (NAT2) enzyme. Single nucleotide polymorphisms (SNPs) in NAT2 gene could classify an individual into three distinct phenotypes: rapid, intermediate and slow acetylators. SNPs acetylator phenotype have been implicated as risk factors for development of antitubercular drug-induced liver injury (AT-DILI) several tuberculosis (TB) populations. We conducted a prospective observational study to characterize compare SNPs,...
Problem consideredIndia has the highest number of envenomation and deaths due to snakebite in world. However, there is wide variation regional prevalence snake species involved causation snakebites. The objectives study were determine causative snakebites presented institution identification risk factors that triggered infliction.MethodsThe cross-sectional was conducted among causalties admitted a tertiary care hospital Malappuram district Kerala. Data collected from medication charts...
The recent outbreaks of Hepatitis A in Kerala are suggestive decrease endemicity as most adults were not exposed during the childhood. In allopathic system medicine, there is no established treatment for and hence people tend to rely on alternate systems medicine. study was aimed at identifying burden locality uncover degree dependence traditional medicine.The spanned over 7 months conducted Malappuram district Kerala. simple questionnaire having closed-ended questions prepared circulated...
Purpose: A 28-year-old male reported to our hospital with Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) overlap syndrome that developed as an adverse drug reaction (ADR) allopurinol. HLA-B*58:01 allele is associated increased risk of developing allopurinol-induced SJS/TEN. Methods: Genomic DNA was extracted from peripheral blood leukocytes. sequencing done using SANGER method. Results: Pharmacogenetic testing results revealed positive for allele. Symptoms the patient receded...
Introduction: Tuberculosis is a major respiratory disease globally with higher prevalence in Asian and African countries than rest of the world. With larger population tuberculosis patients anticipated to be co-infected COVID-19 infection, an ongoing pandemic, identifying, preventing managing drug–drug interactions inevitable for maximizing patient benefits current repurposed antitubercular drugs. Methods: We assessed potential between drugs using drug interaction checker IBM Micromedex®....
Studies mapping genetic heterogeneity of clinical isolates