A5071729745- Ion Transport and Channel Regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Metabolism and Genetic Disorders
- Genetic and Kidney Cyst Diseases
- Biomedical Research and Pathophysiology
- Pancreatic function and diabetes
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
Sun Yat-sen University
2022-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2022-2024
Ischemia/reperfusion (I/R)‐induced acute kidney injury (AKI) is a common clinical syndrome with high morbidity and mortality. Ferroptosis, newly discovered form of oxidative cell death, involved in the pathogenesis renal I/R injury; however, underlying mechanism remains to be explored. Here, we reported that site 1 protease (S1P) promotes ischemic by regulating ferroptotic death tubular epithelial cells. S1P abundance was measured hypoxia/reoxygenation (H/R)‐treated Boston University mouse...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have changed the therapeutic landscape for diabetic kidney disease (DKD) patients, but their underlying mechanisms are complicated and not fully understood. Mitochondria-associated endoplasmic reticulum membranes (MAMs), dynamic contact sites between mitochondria (ER), serve as intracellular platforms important regulating cellular fate function. This study explored roles of SGLT2 in MAMs formation podocytes.
Excessive mitochondrial fission in podocytes serves as a central hub for the pathogenesis of diabetic nephropathy (DN), and thromboxane/prostaglandin receptor (TP receptor) plays potential role DN. However, regulation TP during dynamics disorder remains unknown. Here, we firstly reported novel mechanistic details effects on under conditions. Expression was significantly upregulated conditions both vivo vitro. S18886 attenuated podocyte fission, glomerular injury renal dysfunction mice....