A5082102245- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Insect symbiosis and bacterial influences
- Microbial Community Ecology and Physiology
- Animal Ecology and Behavior Studies
- Genomics and Phylogenetic Studies
- Wastewater Treatment and Nitrogen Removal
- Environmental DNA in Biodiversity Studies
- Rhetoric and Communication Studies
- Neuroscience and Neuropharmacology Research
- Nematode management and characterization studies
- Oral microbiology and periodontitis research
- Insect and Arachnid Ecology and Behavior
- Diet and metabolism studies
- Salivary Gland Disorders and Functions
- Pharmaceutical studies and practices
- Vitamin D Research Studies
- Parasite Biology and Host Interactions
- Invertebrate Taxonomy and Ecology
- Evolution and Genetic Dynamics
- Language, Discourse, Communication Strategies
- Methane Hydrates and Related Phenomena
- Neurological and metabolic disorders
- Entomopathogenic Microorganisms in Pest Control
- Classical Philosophy and Thought
Aarhus University
2016-2025
London Health Sciences Centre
2023
John Wiley & Sons (United States)
2018
Linde (United States)
2018
Gentofte Hospital
1976-2018
Stanford University
2011-2012
Glostrup Hospital
1964-2009
Tel Aviv University
2009
Roche (Denmark)
2009
Aalborg University Hospital
2009
The bone mineral content (B.M.C.) in both forearms (related to total body calcium) was measured by photon absorptiometry for a controlled therapeutic trial representative sample of epileptic outpatients, comprising 226 patients treated with one or two major anticonvulsant drugs (phenytoin, phenobarbitone, primidone). Initially the mean B.M.C. value all 87% normal. During treatment 2,000 international units vitamin D<sub>2</sub> daily three months an average increase 4% found, whereas values...
SUMMARY A consecutive series of patients with epilepsy were allocated at random to one two groups and B on discharge from a neurological department. All given ambulant treatment diphenylhydantoin (phenytoin). The dosage was usually 5–6 mg/kg body weight. group controlled clinically had their serum determined after 2, 6 12 weeks. They told the results blood tests, enjoined take tablets regularly. came consultation blood‐test only By end weeks, 17 out 22 in achieved therapeutic level...
Abstract Identifying and quantifying nitrogen pools is essential for understanding the cycle in aquatic ecosystems. The ubiquitous diatoms represent an overlooked nitrate pool as they can accumulate intracellularly utilize it assimilation, dissipation of excess photosynthetic energy, Dissimilatory Nitrate Reduction to Ammonium (DNRA). Here, we document global co-occurrence intracellular phototrophic microbial communities freshwater ( n = 69), coastal 44), open marine 4) habitats. Diatom...
SUMMARY A double‐blind study of the antiepileptic effect and side effects carbamazepine (CARB) diphenylhydantoin (DPH) was undertaken in 38 patients with psychomotor epilepsy without grand mal except for a single previous seizure. The were treated CARB DPH only, each periods 16 weeks crossover 4 weeks. initial dosage 6 mg/kg or 15 corrected according to serum values aiming at therapeutic intervals 8–16 mg/1 6–10 CARB. trial had be discontinued 12 patients. two drugs preventing seizures same....
The bone mineral mass was estimated by photon absorptiometry in 23 epileptic patients on long-term treatment with phenytoin and 20 normal subjects before during vitamin D or placebo.Initially, subnormal values of were found the patients. group treated showed a significant increase mass. placebo no change
Social spiders have remarkably low species-wide genetic diversities, potentially increasing the relative importance of microbial symbionts for host fitness. Here we explore bacterial microbiomes three species social Stegodyphus (S. dumicola, S. mimosarum and sarasinorum), within between populations, using16S rRNA gene amplicon sequencing. The spider were distinct but shared similarities in membership structure. This included overall diversity (Shannon index 0.5-1.7), strong dominance single...
Understanding the role of genetic and nongenetic variants in modulating phenotypes is central to our knowledge adaptive responses local conditions environmental change, particularly species with such low population diversity that it likely limit their evolutionary potential. A first step towards uncovering molecular mechanisms underlying population-specific environment carry out association studies. We associated climatic variation genetic, epigenetic microbiome populations a social spider...
Previously described cases of phenytoin-induced hyperkinesia are reviewed. Three new reported, in one which persisted for 5 years, although serum phenytoin on several occasions was the therapeutic range. Similarities between and Huntington's chorea neuroleptic- L-DOPA-treated patients discussed. It is pointed out that frequency organic cerebral damage seems to be high among with hyperkinesia. The hypothesis presented induces by increasing dopaminergic serotonergic activity basal ganglia,...
Summary Short laboratory feeding tests were carried out with the anticoagulants warfarin, difenacoum, and brodifacoum on a number of European rodent species: Clethrionomys glareolus, Microtus agrestis, M. arvalis, Apodemus flavicollis, A. sylvaticus, Mus musculus, Rattus rattus R. norvegicus . It was found that toxicity to all species highest lowest only 0·005% would give complete mortality in most after one day's feeding. The potential this compound for control microtine field rodents is suggested.
Of 1,250 patients with convulsive disorders studied during a 13-year period, 37 had attacks preceded by severe "stress." Follow-up examinations were done 1 to 12 years later on 36 of these and 27 children ( ≤ 20 age) 16 the 36. Patients 50 old, twice as many men women. Families propositi showed increased incidences febrile convulsions. Familial disposition epilepsy was not found. One child paroxysmal changes an electroencephalogram only photostimulation. Lack sleep dominating stress factor;...
Disentangling modes and fidelity of symbiont transmission are key for understanding host-symbiont associations in wild populations. In group-living animals, social may evolve to ensure high-fidelity symbionts, since non-reproducing helpers constitute a dead-end vertical transmission. We investigated the spider Stegodyphus dumicola, which lives family groups where majority females helpers, feed offspring by regurgitation, individuals communally on insect prey. Group members share temporally...
ABSTRACT Antimicrobial resistance is an ever-increasing problem for human health, and with only a few novel antimicrobials discovered in recent decades, extraordinary effort needed to circumvent this crisis. A promising source of new microbial-derived antimicrobial compounds resides the large fraction microbes that are not readily cultured by standard cultivation. It has previously been shown nests social spider Stegodyphus dumicola contain diverse bacterial community, where small could be...
Symbiotic bacteria of the genus Verminephrobacter (Betaproteobacteria) were detected in nephridia 19 out 23 investigated earthworm species (Oligochaeta: Lumbricidae) by 16S rRNA gene sequence analysis and fluorescence situ hybridization (FISH). While all four Lumbricus three five Aporrectodea densely colonized a mono-species culture Verminephrobacter, other contained mixed bacterial populations with varying proportions Verminephrobacter; did not contain at all. The symbionts could be grouped...
The incidence of vertebral fractures in 87 epileptic outpatients was 16 per cent. occurrence epileptics not correlated to age, state osteomalacia or type number seizures.
In 151 epileptic patients, who had been treated with phenytoin for from 3 months to 31 years, the three indices of anticonvulsant osteomalacia: Serum calcium, serum alkaline phosphatase, and bone mineral content were studied find relation between pathological changes duration treatment. The results indicate that osteomalacia sets in quite early after institution treatment, is kept at a constant level thereafter. If epileptics should have prophylactic vitamin D extra supply probably he given...
SUMMARY Two consecutive series of epileptic patients with an onset seizures after the age 17 years and a duration not exceeding 5 were submitted to follow‐up examination 4–7 admittance department neurology. Both considered highly representative “the population”. Of 220 22 had died 21 could be contacted. The diagnosis was wrong in 4 cases. One‐hundred seventy‐three re‐examined; 34 % been completely seizure‐free 16 only one observation years. No correlation found between at course disease. A...
Social spiders of the species Stegodyphus dumicola live in communal nests with hundreds individuals and are characterized by extremely low species-wide genetic diversity. The lack diversity combination group living imposes a potential threat for infection pathogens. We therefore proposed that specific microbial symbionts inhabiting spider may provide antimicrobial defense. To compare bacterial fungal 17 from three different locations Namibia, we used 16S rRNA gene internal transcribed spacer...