A5101591866- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Protein Interaction Studies and Fluorescence Analysis
- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects of Natural Compounds
- Berberine and alkaloids research
- Surfactants and Colloidal Systems
- Ionic liquids properties and applications
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Advancements in Transdermal Drug Delivery
- Photochemistry and Electron Transfer Studies
- Protein purification and stability
- Neonatal Health and Biochemistry
- Crystallography and molecular interactions
- Molecular Sensors and Ion Detection
- Water Quality Monitoring and Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Chromatography in Natural Products
- Identification and Quantification in Food
- Cardiovascular Health and Risk Factors
- Sirtuins and Resveratrol in Medicine
- Phytochemicals and Medicinal Plants
Dalian University
2006-2025
Zhejiang Research Institute of Chemical Industry
2016-2020
Zhejiang A & F University
2018
Chinese Academy of Sciences
2002-2013
Dalian Institute of Chemical Physics
2002-2013
Dalian University of Technology
2013
Dalian Medical University
2009
National Institutes of Natural Sciences
2009
Okazaki Institute for Integrative Bioscience
2009
Xinxiang Medical University
2009
AIM:To investigate whether nicotinamide overload plays a role in type 2 diabetes. METHODS:Nicotinamide metabolic patterns of 14 diabetic and non-diabetic subjects were compared using HPLC.Cumulative effects N 1 -methylnicotinamide on glucose metabolism, plasma H2O2 levels tissue adenine dinucleotide (NAD) contents adult Sprague-Dawley rats observed.The human sweat glands rat skin metabolism was investigated sauna burn injury, respectively.
Cerebral ischemia-reperfusion injury (CIRI) is the primary cause of damage following ischemic stroke, with ferroptosis serving as a key pathophysiological factor in CIRI. Pterostilbene (PTE) has been shown to reduce cerebral injury, but whether its mechanism action involves remains unclear. In this study, an vitro model mouse hippocampal neuron (HT22) cell and vivo CIRI were established. Treatments included PTE, activator Erastin, Wnt signaling pathway inhibitor (Dkk-1). Cell was assessed...
A colorimetric probe for the detection of copper(II) ions in aqueous media by naked eye has been developed based on a supramolecular complex comprised cationic polythiophene derivative and ATP with limit as low 0.05 mM.
In this paper, novel high extraction efficiency hydrophobic eutectic solvents (DESs), n-octanoic acid as a hydrogen bond donor (HBD) and menthol acceptor (HBA), were selected from five DESs to extract trace diphenylamine (DPA) in fruits apple, pear orange under ultrasonic-assisted liquid-liquid micro-extraction (UA-LLME) technology before high-performance liquid chromatography (HPLC) analysis. Working parameters such the type, molar ratio, extractant volume, ultrasonic time of LLME...
Abstract A simple pH‐responsive magnetic solid‐phase extraction method was developed using graphene oxide–coated nanoscale zerovalent iron nanoparticles as an efficient adsorbent prior to high‐performance liquid chromatography‐tandem mass spectrometry for determination of ultra‐trace quinolones in milk samples. Various parameters affecting maghemite synthesis and separation such pH sample solution, amount adsorbent, eluent type, volume were optimized. The limits detection are from 3.1 13.3...
The use of deep eutectic solvents (DESs) has great prospects because the green and efficient characteristics, which can be used for developing analytical methods foods. In this research, assisted by ultrasonic waves, a liquid-liquid microextraction detection method combined with gas chromatography was established three anaesthetics (eugenol, isoeugenol, methyl isoeugenol) in aquatic food. processing conditions including components, ratio hydrogen bond acceptor donor, DES volume, time, pH...
A method by combination of centrifugal ultrafiltration (CUF) sampling with liquid chromatography−mass spectrometry (LC−MS) analysis was established to evaluate the DNA structure and sequence selectivity multiple compounds in a small molecule library. The developed applied analyze extracts natural products Coptis chinensis Franch Rheum palmatum (L.). From obtained biological fingerprinting chromatograms, 7 C. 11 R. (L.) were screened out as binding agents. Most these identified standards...
The skin, the body's largest organ, plays an important role in biotransformation/detoxification and elimination of xenobiotics endogenous toxic substances, but its oxidative stress insulin resistance is unclear. We investigated relationship between skin detoxification stress/insulin by examining burn-induced changes nicotinamide degradation. Rats were divided into four groups: sham-operated, sham-nicotinamide, burn, burn-nicotinamide. received intraperitoneal glucose injection (2 g/kg) with...
摘要: 通过水提、酸沉法得到锦灯笼果实提取物,其中蛋白质含量为188 mg/g(以提取物干重计),共含有18种氨基酸,其中8种人体必需氨基酸占氨基酸总量的31%。基于鸟枪法蛋白质组学的分析方法,用纳升级反相液相色谱-串联质谱(nano-RPLC-MS/MS)系统分析锦灯笼果实提取物中蛋白质的酶解产物,结合数据库检索,共鉴定得到60种蛋白质;通过生物信息学分析,得到锦灯笼提取物中的蛋白质具有催化活性、抗氧化活性、酶调节活性、养分贮液囊活性、运输活性、结合活性六大生物活性,其中鉴定到与抗氧化相关的蛋白质有3种,为锦灯笼中蛋白质的功能性质的进一步研究奠定了基础。
In this paper, a new pharmaceutical cocrystal was synthesized using apigenin (AP) and pharmaceutically acceptable conformer nicotinamide (Nico), the drug delivery between AP-Nico human serum albumin (HSA) in vivo studied at atomic scale. The characterized Fourier-transform infrared (FTIR) spectroscopy, 1H NMR differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), self-assembling mechanism explored. dissolution cumulative release vitro were investigated. Molecular dynamic...
地球观测组织GEO(Group on Earth Observations)是地球观测领域规模最大和最具影响力的政府间国际组织,中国是地球观测组织创始国之一,自2005年地球观测组织成立起一直担任代表发展中国家和亚洲大洋洲区域的联合主席国。本文对地球观测组织过去18年的发展实践历程进行了回顾与总结,论述了中国在国内、亚洲大洋洲和国际3个层面的相关工作成果,从治理机制、项目合作、公共产品、人才队伍4个方面设计了中国未来参与地球观测组织全球治理,加速融入全球创新网络,携手构建全球科技共同体的工作内容体系。
In the aquaculture industry, fluoroquinolones are widely used as effective therapeutic agents to prevent animal diseases. The wide bactericidal activity of strongly depends on their concentration. Abuse is considered main reason for possible occurrence residues in aquatic products. increasing presence products may pose potential risks human health. Therefore, it important develop an efficient, sensitive, and reliable method simultaneous determination analysis fluoroquinolones, many HPLC...
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