A5016249654- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Immune Response and Inflammation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cytokine Signaling Pathways and Interactions
- Electrolyte and hormonal disorders
- Sepsis Diagnosis and Treatment
- Inflammasome and immune disorders
- Immune cells in cancer
- T-cell and B-cell Immunology
German Rheumatism Research Centre
2021-2022
Leibniz Association
2021-2022
University of Regensburg
2014-2017
TNF and receptor type 2 (TNFR2) have been shown to be important for generation of myeloid-derived suppressor cells (MDSC). In order analyze whether how TNFR2 passes the effect on, myeloid from TNFR2-deficient mice were compared respective wild-type mice. Primary showed reduced production NO IL-6 which was attributable CD11b(+) CD11c(-) Ly6C(+) Ly6G(-) immature monocytic MDSC. MDSC isolated bone marrow less suppressive T cell proliferation WT-derived These differences on between two mouse...
TNF receptor type 2 (TNFR2) has gained attention as a costimulatory for T cells and critical factor the development of regulatory (Treg) myeloid suppressor cells. Using TNFR2-specific agonist TNCscTNF80, direct effects TNFR2 activation on were investigated in mice. In vitro, TNCscTNF80 induced cell proliferation fashion, also supported vitro expansion Treg addition, retarded differentiation bone marrow-derived immature culture reduced their function. vivo application TNCscTNF80-induced mild...
<title>Abstract</title> Multicellular cytokine networks orchestrate the onset and progression of intestinal inflammation colitis-associated cancer (CAC). Interleukin 22 (IL-22), a member IL-10 superfamily, is known for its ability to promote epithelial cell recovery repair. However, dysregulation IL-22 can inadvertently fuel tumorigenesis through mechanisms that are not completely understood. Here we show IL-22, derived from group 3 innate lymphoid cells (ILC3), directly triggers oncostatin...
Sepsis (hot inflammation) and type 2 diabetes mellitus (T2DM; cold low-grade metabolic exhibit insulin resistance as a common phenotype. In T2DM, we have shown before that the wnt-5a/sFRP-5 system is crucial in development of resistance. The aim present study was to investigate whether pro-inflammatory wnt-5a its specific inhibitor sFRP-5 are also potential mediators between inflammation metabolism human sepsis. this mono-centre prospective observational study, critically ill subjects...