A5103063804- Advanced Battery Technologies Research
- Advanced Sensor and Control Systems
- Advanced Algorithms and Applications
- Electric and Hybrid Vehicle Technologies
- Electric Vehicles and Infrastructure
- Advancements in Battery Materials
- Embedded Systems and FPGA Design
- Oxidative Organic Chemistry Reactions
- Alkaloids: synthesis and pharmacology
- Advanced Battery Materials and Technologies
- Spectroscopy and Laser Applications
- Protein Degradation and Inhibitors
- HIV/AIDS drug development and treatment
- Histone Deacetylase Inhibitors Research
- Atmospheric Ozone and Climate
- Semiconductor Lasers and Optical Devices
- Advanced Computational Techniques and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Railway Systems and Energy Efficiency
- Catalytic C–H Functionalization Methods
- Supercapacitor Materials and Fabrication
- Fuel Cells and Related Materials
- Power Systems and Technologies
- HIV Research and Treatment
- Chemical Synthesis and Reactions
University of Chinese Academy of Sciences
2025
Institute of Semiconductors
2010-2025
Chinese Academy of Sciences
2011-2025
Luxun Academy of Fine Arts
2022
Beijing Jiaotong University
2009-2021
Roche (China)
2010-2020
East China University of Science and Technology
2014
Beijing Technology and Business University
2011
China Automotive Technology and Research Center
2011
Roche (Switzerland)
2010
Chronic hepatitis B virus (HBV) infection is a serious public health burden, and current therapies cannot achieve satisfactory cure rate. There are high unmet medical needs of novel therapeutic agents with differentiated mechanism action (MOA) from the standard care. RG7834, compound dihydroquinolizinone (DHQ) chemical series, first-in-class highly selective orally bioavailable HBV inhibitor which can reduce both viral antigens DNA action. Here we report discovery RG7834 phenotypic screening...
Herein we report the identification of a novel class HDAC6 and HDAC8 selective inhibitors through unique chemistry phenotypic screening strategy. Tetrahydroisoquinoline 12 was identified as potent dual inhibitor from focused library cellular tubulin acetylation p21 induction assays. Scaffold hopping led to discovery an aminotetralin HDAC inhibitors. In particular, 3-R stereoisomer 32 showed highly inhibition against with IC50 values 50 80 nM, respectively. Treatment neuroblastoma BE(2)C...
The state of health (SOH) lithium-ion battery is a critical index for the characteristic batteries. It important to evaluate SOH cells avoid dangerous operating conditions and extend useful life. study about electrochemical impedance characteristics plays an role diagnosing ageing cells. After spectra (EIS) tests rate discharge ability at various temperatures following cycle life tests, relation between capacity batteries presented in this paper. experience same process, but available...
With the development of battery technology, large-scale applications are increasing. In order to obtain a higher current and voltage level improve overall energy efficiency, batteries connected in series parallel. Bulk model is most used simulate packs, simulation results single cell enlarged several times represent pack. But bulk ignores inconsistency between batteries, when magnification large, such as extreme fast charge scenario, this neglect cannot reflect distribution inside Our paper...
Histone deacetylase 6 (HDAC6) removes the acetyl group from lysine residues in a number of non-histone substrates and plays important roles microtubule dynamics chaperone activities. There is growing interest identifying HDAC6-selective inhibitors as chemical biology tools ultimately new therapeutic agents. Herein we report design, synthesis, phenotypic screening novel class 3-aminopyrrolidinone-based hydroxamic acids HDAC6 inhibitors. In particular, α-methyl-substituted enantiomer 33 (3-S)...
Abstract Semiconductor lasers hold significant promise for space laser communication. However, excessive radiation in can cause failures. In principle, quantum dot (QD) are more radiation‐resistant than traditional semiconductor because of their superior carrier confinement and smaller active regions. the multifaceted nature effects on QDs result ongoing controversies. this work, comprehensive tests under simulated conditions InAs/GaAs is conducted to validate performance. The results reveal...
Herein, we describe the pharmacokinetic optimization of a series class-selective histone deacetylase (HDAC) inhibitors and subsequent identification candidate predictive biomarkers hepatocellular carcinoma (HCC) tumor response for our clinical lead using patient-derived HCC xenograft models. Through combination conformational constraint scaffold hopping, lowered in vivo clearance (CL) significantly improved bioavailability (F) exposure (AUC) HDAC while maintaining selectivity toward class I...
A battery model that has the capability of analyzing internal non-uniformity local state variables, including charge (SOC), temperature and current density, is proposed in this paper. The built using a set distributed parameter equivalent circuits. In order to validate accuracy model, customized with embedded T-type thermocouple sensors inside tested. simulated conforms well measured at each test point, maximum difference less than 1 °C. Then, applied analyze evolution processes variables’...
Aldosterone synthase (CYP11B2) inhibitors have been explored in recent years as an alternative therapeutic option to mineralocorticoid receptor (MR) antagonists reduce elevated aldosterone levels, which are associated with deleterious effects on various organ systems including the heart, vasculature, kidney, and central nervous system (CNS). A benzamide pyridine hit derived from a focused screen was successfully developed into series of potent selective 3-pyridyl isoindolin-1-ones CYP11B2...
The characteristics of lithium titanate batteries are investigated in this paper. In order to accelerate the test, have been stored under normal temperature for a month before storage and charged 100%SOC. discharging capacity after is less than that storage, which means loss occurs during storage. However, cycle does not decrease with 1C current increases 0.05C current. It was found didn't occur but decreases first discharge because self-discharge. analysis increment capacity, curves high...
Using Li4Ti5O12 as its anode instead of graphite, the lithium titanate battery has inherent advantages in rate characteristics, cycle life and chemical stability, which is more suitable for rail transit application. As an indicator available energy, state energy (SOE) great importance to estimate. However, most models utilized literature concerning estimation become problematic outlining characteristics battery. In this work, a robust approach SOE presented after considering influence...
Forecasting of the state charge (SOC) Ni-MH battery is most important task for management system hybrid electric vehicle (HEV). On basis analyzing charging and discharging characteristics using advantages radial function (RBF) neural network, model estimating was established with piecewise modeling idea. The tested data which from experiments. Results show that operation speed estimation accuracy forecasting can meet demands in practice has certain value application.
To resolve the problem that terminal voltage of battery cannot effectively reflect internal differences between cells, four parameters including Ohmic resistance, polarization voltage, maximum available capacity and state charge (SOC) were proposed to evaluate consistency pack. The characteristics each parameter during discharge theoretically analyzed experimentally tested.
A new method of the SOC estimation using Luenberger observer technique is presented in this paper. The simulation model proposed modeled Matlab/Simulink and generated into code automatically by Matlab/RTW. Then embedded battery management system (BMS) for estimation. To investigate feasibility reliability approach, constant-current constant-voltage (CC-CV) charging test Beijing dynamic stress (BJDST) are performed to estimate SOC. Results show that approach can accurately within 2% error,...
We demonstrate a series of high output power single-mode terahertz quantum cascade lasers based on semi-insulating surface-plasmon waveguide with tapered geometry structure. The taper half-angle is ranging from 0° to 3°. effects the and laser beam quality are experimentally studied. High single longitudinal mode edge-emission peak powers (92.3 mW) realized. monolithically increases increasing angle. All distributed feedback (DFB) lased in temperature range 70-75 K. highest brightness...
The fabrication and characterization of distributed feedback (DFB) quantum cascade lasers emitting at λ ≈ 8.5 μm are reported. first-order DFB grating structure was defined using the holographic lithography technique. Reliable dynamic single-mode emission with a side-mode suppression ratio 20 dB tuning coefficient −0.277 cm−1/K from 93 to 210 K is obtained in continuous wave mode by high-reflectivity coating on rear facet. output power over 100 mW temperature 80 K.
System identification is a theory and technique which use input output data to build mathematical model provide mature method for linear systems at present, but the nonlinear system we have not yet found easy unity methods.Neural network has strong self-learning ability mapping thus it great potentialities in system. In this paper discuss characteristics of neural system, two typical structure
Power lithium battery of manganese oxide is for the study in this paper, including its heating mechanism. Based on heat production caused by lithium-ion internal resistance, transfer model was built. By computational fluid dynamics (CFD) method, cooling performance a pack composed LiMn2O4 prismatic cells simulated. And experimental data obtained monitoring analyzed. According to method we can make some reasonable proposals system designing.
In order to reduce the energy consumption and operating costs, storage technologies have become a hot research in field of rail transit. The system (ESS), which acts as power source can output during vehicle traction absorb when is braking. This study investigates hybrid (HESS) experimental platform based on dSPACE for preliminary studies post-verification ESS. topology uses two bi-directional dc-dc converters parallel another simulate system. HESS has four modes. experiment result proves...