A5049720966- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Lipid metabolism and biosynthesis
- Microbial Metabolic Engineering and Bioproduction
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- Cerebrovascular and genetic disorders
- Acute Ischemic Stroke Management
- Physiological and biochemical adaptations
- Mosquito-borne diseases and control
- Nitric Oxide and Endothelin Effects
- Insect Utilization and Effects
- Viral Infectious Diseases and Gene Expression in Insects
- Genetics, Aging, and Longevity in Model Organisms
- Bioinformatics and Genomic Networks
- Plant biochemistry and biosynthesis
Technical University of Munich
2025
Heinrich Heine University Düsseldorf
2019-2023
Abstract PAX5 acts as a master regulator of B-cell proliferation and differentiation. Its germline somatic deregulation have both been implicated in the development precursor acute lymphoblastic leukemia (BCP-ALL). However, process how reduced transcriptional activity mediates progression to BCP-ALL, is still poorly understood. Here, we characterized longitudinal effects reduction on healthy, pre-leukemic BCP-ALL cells at single-cell level. Cell-surface marker analysis revealed...
Lipid droplets (LDs) are the universal cellular storage organelles for esterified neutral lipids. The increasing number of characterized LD-associated proteins attained LDs with hitherto unexpected functions on top their classical role as energy depot. Here, we characterize protein CG9186 Drosophila by a CRISPR/Cas9-derived mutant fly line. While flies only showed mild triacylglycerol phenotype, they were highly protected from desiccation stress, likely linked to reduced locomotor activity...
We know a lot about varying gut microbiome compositions. Yet, how the bacteria affect each other remains elusive. In mammals, this is largely based on sheer complexity of with at least hundreds different species. Thus, model organisms such as Drosophila melanogaster are commonly used to investigate mechanistic questions consists only 10 leading bacterial Here, we isolated from laboratory-reared Drosophila, sequenced their respective genomes, and information reconstruct genome-scale metabolic...
Abstract The phenotype of organisms is the result complex interactions between physiology, developmental conditions, and intra-organismic processes, such as metabolism genetic adaptation. Organisms pursue various strategies that depend on factors available resources. How regulate control critical principles not fully understood. In this study, we investigated dynamic development Drosophila melanogaster larvae through in vitro silico experiments. First, enhanced larval metabolic network...
All metazoans are colonized by a complex and diverse set of microorganisms. The microbes colonize all parts the body especially abundant in gastrointestinal tract, where they constitute gut microbiome. fruit fly Drosophila melanogaster turned out to be an exquisite model organism functionally test importance intact Still, however, fundamental questions remain unanswered. For example, it is unknown whether fine-tuned regionalization microbiome exists how such spatial organization could...
Most if not all multicellular organisms are inhabited by a vast number of microorganisms, the so-called microbiome. The bacteria present in digestive system usually most abundant microbiome members and important for various aspects hosts’ physiology. On top making food components accessible, produce e.g. micronutrients required host as well metabolites, which affect several signaling pathways. A lot knowledge exists concerning varying compositions. How gut each other, however, remains...