A5036328784- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Circadian rhythm and melatonin
- Physiological and biochemical adaptations
- Plant and animal studies
- Domain Adaptation and Few-Shot Learning
- Soft Robotics and Applications
- Cancer-related molecular mechanisms research
- Insect Utilization and Effects
- Animal Behavior and Reproduction
- Retinal Development and Disorders
- Human Pose and Action Recognition
- Cell Image Analysis Techniques
- Multimodal Machine Learning Applications
- Advanced Fluorescence Microscopy Techniques
- Neural dynamics and brain function
- Modular Robots and Swarm Intelligence
- Micro and Nano Robotics
- Plant Molecular Biology Research
- RNA Research and Splicing
- Plant and Biological Electrophysiology Studies
- Heavy metals in environment
- Advanced Materials and Mechanics
- Photoreceptor and optogenetics research
- Environmental Quality and Pollution
Zhejiang University
2016-2025
State Key Laboratory of Medical Neurobiology
2024
Zhejiang Lab
2020-2024
Second Affiliated Hospital of Zhejiang University
2020-2024
Center for Neurosciences
2020
University at Buffalo, State University of New York
2019
Institute of Biophysics
2008-2016
Chinese Academy of Sciences
2000-2016
Institute of Applied Ecology
2008
University of Virginia
2004
Hearing in Drosophila depends on the transduction of antennal vibration into receptor potentials by ciliated sensory neurons Johnston's organ, chordotonal organ. We previously found that a protein vanilloid subfamily (TRPV) channel subunit, Nanchung (NAN), is localized to cilia and required generate sound-evoked (Kim et al., 2003). Here, we show only other TRPV mutated behavioral mutant inactive ( iav ). The IAV forms hypotonically activated when expressed cultured cells; flies, it...
The central complex is a prominent structure in the Drosophila brain. Visual learning experiments flight simulator, with flies genetically altered brains, revealed that two groups of horizontal neurons one its substructures, fan-shaped body, were required for visual pattern memory. However, little known about role other components Here we show small set ellipsoid which another substructure and connected to also Localized expression rutabaga adenylyl cyclase either body or sufficient rescue...
In recent years, skeleton based action recognition is becoming an increasingly attractive alternative to existing video-based approaches, beneficial from its robust and comprehensive 3D information. this paper, we explore unsupervised representation learning approach for the first time capture long-term global motion dynamics in sequences. We design a conditional inpainting architecture fixed-dimensional representation, guided by additional adversarial training strategies. quantitatively...
Abstract Accumulating evidence highlights the role of histone acetyltransferase GCN5 in regulation cell metabolism metazoans. Here, we report that is a negative regulator autophagy, lysosome‐dependent catabolic mechanism. In animal cells and Drosophila , inhibits biogenesis autophagosomes lysosomes by targeting TFEB, master transcription factor for autophagy‐ lysosome‐related gene expression. We show specific TFEB acetyltransferase, acetylation results decrease transcriptional activity....
The role of the foraging (for) gene, which encodes a cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase (PKG), in food-search behavior Drosophila has been intensively studied. However, its functions other complex behaviors have not well-characterized. Here, we show experimentally that for gene is required operant visual learning paradigm. Visual pattern memory was normal natural variant rover (for(R)) but impaired another sitter (for(S)), lower PKG level. Memory defects...
Across phyla, body size is linked to climate. For example, rearing fruit flies at lower temperatures results in bigger sizes than those observed higher temperatures. The underlying molecular basis of this effect poorly understood. Here we provide evidence that the temperature-dependent regulation Drosophila depends on a group cold-sensing neurons and insulin-producing cells (IPCs). Electrically silencing IPCs completely abolishes increase induced by cold temperature. are directly innervated...
Appropriate preferences for light or dark conditions can be crucial an animal's survival. Innate are not static in some animals, including the fruit fly Drosophila melanogaster, which prefers darkness feeding larval stage but adulthood. To elucidate neural circuit underlying preference, we examined neurons involved phototactic behavior by regulating neuronal functions. Modulating activity of two pairs isomorphic central brain switched preference between photophobic and photophilic. These...
Long non-coding RNAs (lncRNAs) that have no protein-coding capacity make up a large proportion of the transcriptome various species. Many lncRNAs are expressed within animal central nervous system in spatial- and temporal-specific patterns, indicating play important roles cellular processes, neural development, even cognitive behavioral processes. However, relatively little is known about their vivo functions underlying molecular mechanisms system. Here, we report neural-specific Drosophila...
Unsupervised domain adaptation methods aim to alleviate performance degradation caused by domain-shift learning domain-invariant representations. Existing deep focus on holistic feature alignment matching source and target distributions, without considering local features their multi-mode statistics. We show that the learned patterns are more generic transferable a further distribution enables fine-grained alignment. In this paper, we present method for jointly aligning Comparisons...
Domain adaptation is an important technique to alleviate performance degradation caused by domain shift, e.g., when training and test data come from different domains. Most existing deep methods focus on reducing shift matching marginal feature distributions through transformations the input features, due unavailability of target labels. We show that may still exist via label distribution at classifier, thus deteriorating model performances. To this issue, we propose approximate joint scheme...
Soft crawling robots have been widely studied and applied because of their excellent environmental adaptability flexible movement. However, most existing soft typically exhibit a single-motion mode lack diverse capabilities. Inspired by
Small-scale (from centimeters down to micrometers) parallel robots with high precision are widely utilized in various industrial and biomedical settings, while such superiorities remain challenges for soft (SPRs). In this work, we propose an integrated design fabrication strategy make up a lightweight (3.5 g) small-scale ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\phi...
The Drosophila larva, a soft-body animal, can bend its body and roll efficiently to escape danger. However, contrary common belief, this rolling motion is not driven by the imbalance of gravity ground reaction forces. Through functional imaging ablation experiments, we demonstrate that sequential actuation axial muscles within an appropriate range angles critical for generating rolling. We model interplay between muscle contraction, hydrostatic skeleton deformation, body-environment...
Innate preference toward environmental conditions is crucial for animal survival. Although much known about the neural processing of sensory information, how aversive or attractive stimulus transformed through central brain neurons into avoidance approaching behavior largely unclear. Here we show that Drosophila larval light regulated by a disinhibitory mechanism. In circuit, pair GABAergic exerts tonic inhibition on one contralateral projecting control reorientation behavior. When larva...
Correct pathfinding and target recognition of a developing axon are exquisitely regulated processes that require multiple guidance factors. Among these factors, the second messengers, cAMP cGMP, known to be involved in establishing cues for growth through different intracellular signaling pathways. However, whether how cGMP-dependent protein kinase (PKG) regulates remains poorly understood. Here, we show motor axons intersegmental nerve b (ISNb) Drosophila embryo display targeting defects...
Abstract Cathepsin D (cathD) is traditionally regarded as a lysosomal protease that degrades substrates in acidic compartments. Here we report cathD plays an unconventional role cofilin phosphatase orchestrating actin remodeling. In neutral pH environments, the precursor directly dephosphorylates and activates actin-severing protein independent of its proteolytic activity, whereas mature conditions. During development, complements canonical slingshot regulates morphogenesis actin-based...
Summary Edges represent important information in object recognition, and thus edge detection is crucial for animal survival. Various types of edges result from visual contrast, such as luminance contrast color contrast. Thus far, the molecular neural mechanisms underlying relationship between different information-processing pathways have largely been undemonstrated. In present study, using a color-light-emitting diode (LED)-based Buridan's paradigm, we demonstrated that blue/green...