A5046141573- Synthetic Organic Chemistry Methods
- Traditional and Medicinal Uses of Annonaceae
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Cardiac Fibrosis and Remodeling
- Trace Elements in Health
- Epigenetics and DNA Methylation
- Insect Resistance and Genetics
- Cardiovascular Function and Risk Factors
- Microbial Natural Products and Biosynthesis
- Carbohydrate Chemistry and Synthesis
- Cardiac Ischemia and Reperfusion
- Endoplasmic Reticulum Stress and Disease
- Entomopathogenic Microorganisms in Pest Control
- Neurological Disorders and Treatments
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Effects of Natural Compounds
- Neurological and metabolic disorders
- Microbial metabolism and enzyme function
- Renin-Angiotensin System Studies
- Skin Protection and Aging
- Pharmacology and Obesity Treatment
- Marine Toxins and Detection Methods
- Caveolin-1 and cellular processes
- 14-3-3 protein interactions
Niigata University
2007-2022
Daiichi-Sankyo (Japan)
2018-2022
University of Shizuoka
2021-2022
Hokkaido University
2007-2008
Tokyo University of Agriculture and Technology
2007
Showa University
2006
Therapeutic reactivation of the γ-globin genes for fetal hemoglobin (HbF) production is an attractive strategy treating β-thalassemia and sickle cell disease. It was reported that genetic knockdown histone lysine methyltransferase EHMT2/1 (G9a/GLP) sufficient to induce HbF production. The aim present work acquire a G9a/GLP inhibitor induces sufficiently. revealed tetrahydroazepine has versatility as side chain in various skeletons. We ultimately obtained promising aminoindole derivative...
Ecklonia stolonifera Okamura extract (ESE) has been reported to have various bioactive effects, but its effects on cardiovascular disease not yet investigated. First, primary neonatal rat cultured cardiomyocytes were treated with ESE and stimulated phenylephrine (PE) for 48 h. (1000 µg/mL) significantly suppressed PE-induced cardiomyocyte hypertrophy, hypertrophy-related gene transcription, the acetylation of histone H3K9. An in vitro p300-HAT assay indicated that directly inhibited...
Abstract The synthesis of the A- and F-rings goniodomin A (1), which is a stereochemically unidentified antifungal agent isolated from dinoflagellate Alexandrium hiranoi, was performed to determine relative stereochemistry these parts. first deduced Murakami’s NMR data, model compounds corresponding parts were then synthesized. synthetic A-ring model, structure established by X-ray crystallographic analysis, showed good agreement with natural on basis J NOE behavior in 1H spectroscopy....
Drug repositioning has recently emerged as a strategy for developing new treatments at low cost. In this study, we used library of approved drugs to screen compounds that suppress cardiomyocyte hypertrophy. We identified the antiplatelet drug sarpogrelate, selective serotonin-2A (5-HT2A) receptor antagonist, and investigated drug’s anti-hypertrophic effect in cultured cardiomyocytes its on heart failure vivo. Primary pretreated with sarpogrelate were stimulated angiotensin II, endothelin-1,...
It is well known that the anthracycline anticancer drug doxorubicin (DOX) induces cardiotoxicity. Recently, Chrysanthemum morifolium extract (CME), an of purple chrysanthemum flower, has been reported to possess various physiological activities such as antioxidant and anti-inflammatory effects. However, its effect on DOX-induced cardiotoxicity still unknown. An 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT)assay revealed 1 mg/mL CME reduced cytotoxicity in H9C2 cells but...
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Background: Delayed non-malignant complications after allogeneic hematopoietic cell transplantation (allo-HCT) affect quality of life and increase the risk premature death over 10 fold. Although about half all deaths allo-HCT are due to primary disease, non-relapse mortality (NRM) is also a major issue for long-term follow-up. Transplant endothelial activation stress index prior (EASIX-pre) were reported be predictive markers NRM allo-HCT. However, factors late 1 year from allo-HCT, which...
Introduction: Heart failure is the leading cause of death in world. Cardiomyocyte hypertrophy observed during development heart failure, suggesting that its inhibition a potential target for prevention and treatment failure. In this study, we screened natural compound library using cultured cardiomyocytes found Ecklonia stolonifera Okamura extract (ESE) suppressed cardiomyocyte hypertrophy. ESE, perennial brown alga, has been reported to have various bioactive effects, such as antioxidant...