A5044754217- Spinal Fractures and Fixation Techniques
- Advanced MRI Techniques and Applications
- Surgical Simulation and Training
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Medical Imaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Anatomy and Medical Technology
- Functional Brain Connectivity Studies
- Augmented Reality Applications
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- MRI in cancer diagnosis
- Bipolar Disorder and Treatment
- Genetic Neurodegenerative Diseases
- Management of metastatic bone disease
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Radiation Dose and Imaging
- Head and Neck Surgical Oncology
- Cell Adhesion Molecules Research
- Advanced Radiotherapy Techniques
Philipps University of Marburg
2016-2025
Center for Behavioral Brain Sciences
2019-2025
Brain (Germany)
2019-2024
Justus-Liebig-Universität Gießen
2024
Universitätsklinikum Gießen und Marburg
2018
Marquette General Hospital
2017
St. Anne's University Hospital Brno
2016
Background: Pharmacoresistant epilepsy affects approximately one-third of all patients, and resective surgery may offer favorable outcomes for carefully selected patients with focal epilepsy. The accurate identification the epileptogenic zone (EZ) is essential successful surgery, particularly in cases where non-invasive diagnostics are inconclusive. Invasive stereoelectroencephalography (SEEG) a reliable approach to localizing EZ, especially MRI-negative cases. Methods: This retrospective...
Study Design: A prospective, case-based, observational study. Objectives: To investigate how microscope-based augmented reality (AR) support can be utilized in various types of spine surgery. Methods: In 42 spinal procedures (12 intra- and 8 extradural tumors, 7 other intradural lesions, 11 degenerative cases, 2 infections, deformities) AR was implemented using operating microscope head-up displays (HUDs). Intraoperative low-dose computed tomography used for automatic registration. Nonlinear...
Low registration errors are an important prerequisite for reliable navigation, independent of its use in cranial or spinal surgery. Regardless whether navigation is used trajectory alignment biopsy implant procedures, sophisticated augmented reality applications, all depend on a correct patient space and image space. In contrast to fiducial, landmark, surface matching-based registration, the application intraoperative imaging allows user-independent automatic which less error prone. The...
BackgroundThe need for imaging-guided optimization of Deep Brain Stimulation (DBS) parameters is increasing with recent developments sophisticated lead designs offering highly individualized, but time-consuming and complex programming.ObjectiveThe objective this study was to compare changes in motor symptoms Parkinson's Disease (PD) the corresponding volume electrostatic field (VEsF) achieved by DBS programming using GUIDE XT™, a commercially available software visualization leads within...
The aim of this study was to report on the clinical experience with microscope-based augmented reality (AR) in transsphenoidal surgery compared classical approach. AR support established using head-up displays operating microscope, navigation based fiducial-/surface- or automatic intraoperative computed tomography (iCT)-based registration. In a consecutive single surgeon series 165 procedures, 81 patients underwent without and 84 support. integrated straightforwardly within workflow....
Abstract Deep brain stimulation of the subthalamic nucleus (STN-DBS) effectively treats motor and non-motor symptoms in advanced Parkinson’s disease (PD). As considerable interindividual variability outcomes exists, neuroimaging-based biomarkers, including microstructural metrics, have been proposed to anticipate treatment response. In this prospective open-label study, we sought detect properties areas associated with short-term following STN-DBS. Thirty-seven PD patients underwent...
Despite its broad use in cranial and spinal surgery, navigation support microscope-based augmented reality (AR) have not yet found their way into posterior fossa surgery the sitting position. While this position offers surgical benefits, accuracy thereof of itself seems limited. Intraoperative ultrasound (iUS) can be applied at any time during delivering real-time images that used for verification updates. Within study, applicability was assessed. Data from 15 patients with lesions within...
Background: The aim of surgery for skull base meningiomas is maximal resection with minimal damage to the involved cranial nerves and cerebral vessels; thus, implementation technologies improved orientation in surgical field, such as neuronavigation augmented reality (AR), interest. Methods: Included study were 39 consecutive patients (13 male, 26 female, mean age 64.08 ± 13.5 years) who underwent using microscope-based AR automatic patient registration intraoperative computed tomography...
Glioblastoma (GBM) as the most common and aggressive brain tumor is characterized by genetic heterogeneity, invasiveness, radio-/chemoresistance, occurrence of GBM stem-like cells. The metalloprotease-disintegrin ADAM8 highly expressed in immune cells correlates with poor survival. In GBM, affects intracellular kinase signaling increases expression levels osteopontin/SPP1 matrix metalloproteinase 9 (MMP9) an unknown mechanism. Here we explored whether microRNA (miRNA) could be regulators...
Addressing conventional neurosurgical navigation systems’ high costs and complexity, this study explores the feasibility accuracy of a simplified, cost-effective mixed reality (MRN) system based on laser crosshair simulator (LCS). A new automatic registration method was developed, featuring coplanar emitters recognizable target pattern. The workflow integrated into Microsoft’s HoloLens-2 for practical application. assessed system’s precision by utilizing life-sized 3D-printed head phantoms...
Our study presents a single center experience in resection of intradural spinal tumors either with or without using intraoperative CT (iCT)-based registration and microscope-based augmented reality (AR). Microscope-based AR was recently described for improved orientation the operative field spine surgery, superimposed images segmented structures interest two- (2D) three-dimensional (3D) mode. All patients who underwent surgery at our department were retrospectively included study. Clinical...
Mixed reality navigation (MRN) technology is emerging as an increasingly significant and interesting topic in neurosurgery. MRN enables neurosurgeons to "see through" the head with interactive, hybrid visualization environment that merges virtual- physical-world elements. Offering immersive, intuitive, reliable guidance for preoperative intraoperative intervention of intracranial lesions, showcases its potential economically efficient user-friendly alternative standard neuronavigation...
INTRODUCTION: Pedicle-screw (PS)-instrumentation is a common procedure for the management of degenerative, infectious, oncological spine-diseases with instability and spine-fractures. Free-hand fluoroscopy-guided PS-placement are traditional methods, whereas navigation-guided PS-placement, either surface-based matching or automatic registration intraoperative imaging, additionally robotic-guided have emerged in past two decades. Navigation- surgery shows increased PS-accuracy-placement....
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established intervention for alleviating both motor and non-motor symptoms in advanced Parkinson's disease (PD). However, patient outcomes may vary widely, underscoring need predictive biomarkers. Neuroimaging techniques, such as neurite orientation dispersion density imaging (NODDI), a biophysical model-based MRI technique, offer promise forecasting clinical supporting preoperative counseling. This prospective, open-label...
BackgroundIntermittent theta-burst stimulation (iTBS), a novel repetitive transcranial magnetic (rTMS) technique, appears to have antidepressant effects when applied over left dorsolateral prefrontal cortex (DLPFC). However, its underlying neurobiological mechanisms are unclear. Proton resonance spectroscopy (1H-MRS) provides in vivo measurements of cerebral metabolites altered major depressive disorder (MDD) like N-acetyl-aspartate (NAA) and choline-containing compounds (Cho). We used MRS...
Abstract Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer with a median survival only 15 months. To complement standard treatments including surgery, radiation and chemotherapy, it essential to understand contribution GBM tumor microenvironment. Brain macrophages microglia particularly contribute angiogenesis, major hallmark GBM. ADAM8 , metalloprotease-disintegrin strongly expressed in cells associated immune GBMs, related angiogenesis correlates poor clinical...