A5101792975- Hereditary Neurological Disorders
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Parallel Computing and Optimization Techniques
- Peripheral Neuropathies and Disorders
- Peripheral Nerve Disorders
- Advances in Oncology and Radiotherapy
- Genetic Neurodegenerative Diseases
- Bone health and treatments
- Medical Imaging Techniques and Applications
- Distributed and Parallel Computing Systems
- Advanced Data Storage Technologies
- Ophthalmology and Eye Disorders
- Autopsy Techniques and Outcomes
- Advanced X-ray and CT Imaging
- Science, Research, and Medicine
- Cloud Computing and Resource Management
- Radiation Effects in Electronics
- Cerebral Palsy and Movement Disorders
- Medical and Biological Sciences
- Pain Mechanisms and Treatments
- Phytoplasmas and Hemiptera pathogens
- Biomedical and Engineering Education
- Distributed systems and fault tolerance
- Cancer Diagnosis and Treatment
Barrow Neurological Institute
2022-2023
Cognitive Neuroimaging Lab
2023
University of Wisconsin–Madison
2001-2022
University of Wisconsin Carbone Cancer Center
2020
Mispredicted branches and loads that miss in the cache cause majority of retirement stalls experienced by sequential processors; we call these critical instructions. Despite their importance, a processor has difficulty prioritizing computations (computations instructions), because it must fetch all sequentially, regardless contribution to performance. Speculative data-driven multithreading (DDMT) is general-purpose mechanism for overcoming this limitation. In DDAT are annotated so they can...
We previously reported the safety and immunologic effects of a DNA vaccine (pTVG-HP [MVI-816]) encoding prostatic acid phosphatase (PAP) in patients with recurrent, nonmetastatic prostate cancer. The current trial evaluated this on metastatic progression.Ninety-nine castration-sensitive cancer prostate-specific antigen (PSA) doubling time (DT) less than 12 months were randomly assigned to treatment either pTVG-HP co-administered intradermally 200 μg granulocyte-macrophage colony-stimulating...
Intrapatient treatment response heterogeneity is under-recognized. Quantitative total bone imaging (QTBI) using 18F-NaF positron emission tomography/computed tomography (PET/CT) scans a tool that allows characterization of interlesional in bone. Understanding spatial-temporal important to identify individuals who may benefit from beyond progression.Men with progressive metastatic castration-resistant prostate cancer (mCRPC) at least two lesions on scintigraphy were enrolled and treated...
Speculation will overcome the limitations in dividing a single program into multiple threads that can execute on logical processing elements needed to enhance performance through parallelization.
Patients with polyneuropathies typically have demyelination and/or axonal degeneration in peripheral nerves. Currently, there is a lack of imaging biomarkers to track the changes these pathologies.
We describe dead value information (DVI) and introduce three new optimizations which exploit it. DVI provides assertions that certain register values are dead, meaning they will not be read before being overwritten. The processor can use to track registers dynamically eliminate unnecessary save restore instructions from the execution stream at procedure calls context switches. Our results indicate dynamic saves instances reduced by 46% for 51% In addition, save/restore elimination improve...
Abstract Objective. Manual disease delineation in full-body imaging of patients with multiple metastases is often impractical due to high burden. However, this a clinically relevant task as quantitative image techniques assessing individual metastases, while limited, have been shown be predictive treatment outcome. The goal work was evaluate the efficacy deep learning-based methods for skeletal and compare their performance existing terms accuracy prognostic power. Approach. 1833 suspicious...
This report details curricular recommendations for graduate degrees in medical physics and serves as an update to Report No. 197. In this section, we review the history of American Association Physicists Medicine (AAPM) recommendations, present aims report, detail how these should be interpreted. The first AAPM publication on education was 44, published 1993, describing Master Science Degree Medical Physics.1 79 2002 established a core curriculum all training physics, well more specific...
TPS205 Background: ECF/X (epirubicin + cisplatin 5-FU or capecitabine (X)) is a preferred GC chemotherapy (CT) regimen. Survival of HER2+ metastatic prolonged by trastuzumab when administered with CF/X (VanCutsem, ASCO 2009). Lapatinib inhibits both EGFR1 and HER2, active in gastric cell lines, has shown clinical activity uncontrolled phase II trials. A III trial lapatinib X oxaliplatin (FISH) ongoing. Additional unaddressed questions include the efficacy safety its patients (pts) discordant...
Register integration (or simply integration) is a mechanism for incorporating speculative results directly into sequential execution using data-dependence relationships. In this paper we use to implement squash reuse, the salvaging of instruction that were needlessly discarded during course recovery from control- or datamis-speculation. To integration, first allow squashed instructions remain in physical register file past mis-speculation recovery. As processor re-traces portions path, logic...
Charcot-Marie-Tooth type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsy (HNPP) are caused by mutations the peripheral myelin protein 22 (PMP22) gene. A need exists for sensitive reliable biomarkers of progression treatment response. Magnetic resonance imaging (MRI) metrics nerve pathology morphology were investigated this purpose.MRI was performed at 3.0 T in thigh CMT1A (N = 11) HNPP patients 12) controls 23). Three potential sciatic investigated: 1) magnetization...
<h3>Objective:</h3> To develop a multiparametric quantitative MRI (qMRI) method to track pathological changes of peripheral nerves in patients with neuropathies. <h3>Background:</h3> Irrespective the causes or types polyneuropathies, are mainly afflicted by two kinds pathologies – axonal loss and demyelination. It is critical differentiate as treatments different for conditions. While nerve conduction studies (NCS) have been used distal nerves, there no tools probe proximal nerves. This...
New biomarkers are needed in Guillain-Barre Syndrome to predict patient recovery and severe complications aid drug development. We propose using magnetization transfer (MT) MRI measure myelin content act as such a biomarker. have shown the ability of MT imaging visualize cauda equina, but further work is confirm these differences biomarker suitability.
Magnetization transfer ratio (MTR) and volume of thigh muscles were investigated as imaging biomarkers in Charcot-Marie-Tooth type 1A (CMT1A) hereditary neuropathy with liability to pressure palsy (HNPP) patients. MTR was significantly different between HNPP healthy control subjects; muscle CMT1A patients subjects found be repeatable reliable.
This study developed a multiparametric qMRI method to quantify fat fraction of leg muscles, myelin and axonal pathologies peripheral nerves using MTR, MTsat, T1, PD, T2*, FA, MD, AD, RD, nerve fascicular volume. The results will be applied in ongoing longitudinal studies develop monitoring biomarkers patients with polyneuropathies.
Metastatic cancer patients invariably develop treatment resistance. Different levels of resistance lead to observed heterogeneity in response. The main goal was evaluate response with a computation model simulating the dynamics drug-sensitive and drug-resistant cells. Model parameters included proliferation, drug-induced death, transition proportion intrinsically resistant benchmarked imaging metrics extracted from 39 metastatic prostate who had 18F-NaF-PET/CT scans performed at baseline...
Micro-architectural techniques of the next decade will have to be more efficient and scalable in order handle growing workloads longer communication memory latencies. We believe that information about program structure, data control relationships between instructions, can used as a powelful framework for new techniques. argue structure has several inherent advantages over frameworks associate either with instructions isolation or data. present summaries four novel methods apply system...
This year's Annual Student Meeting consists of a panel professionals who have pursued traditional education in medical physics and since variety careers. These range from chief physicist, small business founder, FDA scientist, industry R&D academic researcher. Each panelist will discuss their education, positions that they held leading to current one, factors influenced them pursue Time be left at the end talk open floor for questions students trainees. Discussion between presenters...
Purpose: A method to guide mid‐treatment biopsies using quantitative [F‐18]NaF PET/CT response is being investigated in a clinical trial. This study aims develop methodology identify patients amenable biopsy based on pre‐treatment imaging characteristics. Methods: 35 metastatic prostate cancer had NaF scans taken prior the start of treatment and 9–12 weeks into treatment. For targeting, lesions must be at least 1.5 cm 3 located clinically feasible region (lumbar/sacral spine, pelvis,...
Magnetization transfer (MT) can be quantified as the MT ratio (MTR), saturation (MTsat), and quantitative (qMT) pool-size-ratio (PSR). MTR is a promising peripheral nerve imaging biomarker in inherited neuropathies but has lower pathological specificity compared to MTsat PSR. Here, metrics are Eighteen subjects received 16 qMT scans, five T 1 -weighted B 0 fields were measured. Mean MTR, MTsat, PSR extracted from sciatic nerve. had highest SNR (median&gt;15.76) scan-rescan repeatability...
e16516 Background: Methods for molecular image-guided biopsies have been limited to targeting lesions with high radiotracer uptake. The purpose of this study is determine the value using imaging response select biopsy. Methods: 7 metastatic prostate cancer patients received 18 F-NaF PET/CT scans at baseline and after 12 weeks enzalutamide therapy. Lesion uptake was quantified semi-automatically. Lesions were classified as partially responding (PR, significantly decreased uptake), stable...