A5100655245- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Luminescence and Fluorescent Materials
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Photochromic and Fluorescence Chemistry
- Supramolecular Chemistry and Complexes
- Supramolecular Self-Assembly in Materials
- Micro and Nano Robotics
- Analytical Chemistry and Chromatography
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Analysis
- Selenium in Biological Systems
- Organoselenium and organotellurium chemistry
- Metalloenzymes and iron-sulfur proteins
- Conducting polymers and applications
- Electrocatalysts for Energy Conversion
- 3D Printing in Biomedical Research
- Analytical Chemistry and Sensors
- Graphene and Nanomaterials Applications
- Sulfur Compounds in Biology
Hangzhou Normal University
2021-2025
Northwestern Polytechnical University
2024-2025
Ministry of Industry and Information Technology
2024-2025
State Key Laboratory of Supramolecular Structure and Materials
2017-2023
Jilin University
1999-2023
Central South University
2021
The design of smart surfaces with switchable adhesive properties in a wet environment has remained challenge adhesion science and materials engineering. Despite intense demands various industrial applications exciting progress mimicking the remarkable through delicate control catechol chemistry, polyelectrolyte complex, supramolecular architectures, full recapitulation nature's dynamic function is limited. Here, we show facile approach to synthesize bioinspired adhesive, which entails...
Abstract The atomically monodispersed dual‐atom nanozyme not only possesses the advantages of homogeneous active centers and high atomic utilization efficiency but also exhibits amazing synergistic effect for higher catalytic activities than single‐atom nanozyme. However, how to construct with multi‐enzyme cascade capacity protecting against brain tissue damage is a great challenge. Herein, coping secondary caused by explosive generation reactive oxygen species(ROS) during cerebral...
Abstract A series of single‐chain random heteropolymer (RHP)‐derived artificial ion channels with both high K + selectivity and controllable pH‐gated behaviors were fabricated by a facile “one‐pot” polymerization method. The benzo‐18‐crown‐6 moieties appended on lateral chains RHPs can form ion‐permeable nanopores transport over Na through the lipid bilayers. permeation was significantly enhanced incorporating cholesterol group to serve as membrane anchor. Interestingly, similar natural...
Abstract Rationally designed multiporphyrinic architectures for boosting photodynamic therapy (PDT) have attracted significant attentions recently years due to their great potential light‐mediated generation of reactive oxygen species. However, there is still a gap between the structure design and PDT performance biomedical applications. This tutorial review provides historical overview on (i) basic concept deeply understanding porphyrin‐mediated reactions, (ii) developing strategies...
Abstract Self‐propelled nanomotors, which can autonomous propelled by harnessing others type of energy, have shown tremendous potential as drug delivery systems for cancer therapy. However, it remains challenging nanomotors in tumor theranostics because their structural complexity and deficient therapeutic model. Herein, glucose‐fueled enzymatic (GC6@cPt ZIFs) are developed through encapsulation glucose oxidase (GOx), catalase (CAT), chlorin e6 (Ce6) using cisplatin‐skeletal zeolitic...
Abstract Protein assembly is the structural basis for collaboration between proteins to accomplish life activities due its realization of domain‐limited and precise spatial arrangement proteins. Therefore, artificial manipulation protein self‐assembly has profound implications in areas such as exploring mysteries developing biomaterials. In this review, we not only summarize classical strategies structures exquisite assemblies, but also aim generalize flexible controllable tools...
Activating antigen-presenting cells is essential to generate adaptive immunity, while the efficacy of conventional activation strategies remains unsatisfactory due suboptimal antigen-specific priming. Here, in situ polymerization-mediated antigen presentation (IPAP) described, which antigen-loaded nanovaccines are spontaneously formed and efficiently anchored onto surface dendritic vivo through co-deposition with dopamine. The resulting chemically bound can promote by elevating...
Abstract Developing artificial ion transport systems, which process complicated information and step‐wise regulate properties, is essential for deeply comprehending the subtle dynamic behaviors of natural channel proteins (NCPs). Here a photo‐controlled logic‐gated K + based on single‐chain random heteropolymers containing molecular motors, exhibiting multi‐core processor‐like properties to control reported. Designed with oxygen, deoxygenation, different wavelengths light as input signals,...
A brief overview of main strategies to improve the gene transfection efficiency PCVs recently and their applications in certain diseases.
Abstract Nanozymes are emerging nanomaterials with ideal enzymatic catalytic performance. The development of nanozymes has been shown clear potential to overcome the limitations natural enzymes such as troublesome preparation, ease denaturation, high price, and difficulty recycling. Since discovery magnetic Fe 3 O 4 nanoparticles intrinsic peroxidase‐like activity in 2007, researches on have booming next decade. According unique nanoscale effect, show prominent performance, which enables...
Sunlight-driven hydrogen production provides a sustainable solution for clean energy generation. Despite their potential, extracellular photosensitized biohybrid systems are typically hindered by sluggish electron transfer between semiconductor materials and microorganisms. Herein, we introduce bioinspired development, the membrane-anchoring protein approach, to overcome this limitation. Using incorporated with TiO2 binding peptide on engineered E. coli, establish proof-of-concept...
Abstract The explosive growth of information and its widespread availability underscores the need for robust encryption anticounterfeiting measures. In this study, CdS quantum dots are engineered (QDs) to manifest multiple visual responses a single trigger through strategic ligand design. surface engineering method allows QDs transition from yellow black upon photoexcitation‐induced electron transfer Cd(II) Cd(0). Surface ligands desorption under hole injection, leading an increase in size...
Abstract Plant chloroplasts have a highly compartmentalized interior, essential for executing photocatalytic functions. However, the construction of reaction compartment similar to in inorganic–biological hybrid systems (IBS) has not been reported. Drawing inspiration from chloroplast and phenomenon liquid–liquid phase separation, herein, new strategy is first developed constructing subcellular system through separation technology living cells. Photosensitizers vivo expressed hydrogenases...
Abstract Although natural dual‐ion exchangers are indispensable for bio‐organic functions, developing their artificial counterparts remains nearly unexplored. Herein, this work proposes a novel light‐controlled K + /Na ‐transport‐exchanger TE12 , realizing an unprecedented reversible switch between ‐ and Na ‐transmembrane transport by changing its mechanism (channel carrier). The conformational transformation of the azobenzene moiety in essentially induces this. selectivity ‐channel...
Abstract Potassium ion channels specifically transport K + ions over Na across a cell membrane. A queue of four binding sites in the channel pore plays significant roles during highly selective conduction. kind aromatic helical oligomer was synthesized that can selectively bind . By stacking oligomers, type artificial with contiguous constructed. Such exhibited exceptionally high /Na selectivity ratios transmembrane
The in situ generation of H
To advance the exploration of mechanisms underlying natural multi-gated ion channels, a novel butterfly-shaped biomimetic K+ channel GnC7 (n = 3, 4) is developed with dual mechanical and pH responsiveness, exhibiting unprecedented K+/Na+ selectivity (G3C7: 34.4; G4C7: 41.3). These channels constructed from poly(propylene imine) dendrimer benzo-21-crown-7-ethers achieve high transport activity (EC50: 0.72 µm for G3C7; 0.9 G4C7) due to their arc-like rotation. The dynamic mode relies on...
Allosteric modulation of protein function, which involves effector binding triggering distant conformational changes, is crucial for cellular and metabolic control. However, achieving tunable control, structural diversity, precise intracellular regulation remains challenging. Here, we designed dynamic supramolecular assemblies driven by enzyme-substrate interactions antioxidant in cells. Using a glutathione S-transferase modified with cysteine mutation (GSTK77C), engineered an molecule...
Natural channel proteins (NCPs) have numerous ion transport modes, but it remains a big challenge to replicate this trait by artificial systems. Herein, we present an azobenzene-incorporated single-chain random heteropolymers (RHPs)-derived biomimetic K+ P3, which can switch between three states ("ON," "Partially OFF," and "Totally OFF") in both liposomes cancer cells. The conformational adjustments of P3 activated light-modulating two groups supramolecular interactions ((1) hydrogen bonding...