A5101739207- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Receptor Mechanisms and Signaling
Estrogen-dependent transcriptional activation by estrogen receptor alpha (ERalpha) depends on the conformation of helices 3 and 12 in ligand-binding domain. To better understand function helix ERalpha, we examined role charged residues, which are conserved most steroid receptors 3, estrogen-dependent transactivation. The replacement Asp-351 with lysine (D351K) or leucine (D351 L) completely abolished transactivation without affecting estrogen-binding, DNA-binding homodimerization activities...
Purpose In this trial, we investigated the efficacy and safety of adjuvant letrozole for hormone receptor (HR)-positive breast cancer. Here, report clinical outcome in postmenopausal women with HR-positive cancer treated according to estrogen (ER) expression levels. Methods multi-institutional, open-label, observational study, patients received (2.5 mg/daily) 5 years unless they experienced disease progression or unacceptable toxicity withdrew their consent. The were stratified into...