Jun Hyun Kim

ORCID: 0000-0003-1615-8219
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Research Areas
  • Estrogen and related hormone effects
  • Cytokine Signaling Pathways and Interactions
  • Breast Cancer Treatment Studies
  • Advanced Breast Cancer Therapies
  • Receptor Mechanisms and Signaling

Estrogen-dependent transcriptional activation by estrogen receptor alpha (ERalpha) depends on the conformation of helices 3 and 12 in ligand-binding domain. To better understand function helix ERalpha, we examined role charged residues, which are conserved most steroid receptors 3, estrogen-dependent transactivation. The replacement Asp-351 with lysine (D351K) or leucine (D351 L) completely abolished transactivation without affecting estrogen-binding, DNA-binding homodimerization activities...

10.1677/jme.1.01846 article EN Journal of Molecular Endocrinology 2005-12-01

Purpose In this trial, we investigated the efficacy and safety of adjuvant letrozole for hormone receptor (HR)-positive breast cancer. Here, report clinical outcome in postmenopausal women with HR-positive cancer treated according to estrogen (ER) expression levels. Methods multi-institutional, open-label, observational study, patients received (2.5 mg/daily) 5 years unless they experienced disease progression or unacceptable toxicity withdrew their consent. The were stratified into...

10.4048/jbc.2021.24.e17 article EN cc-by-nc Journal of Breast Cancer 2021-01-01
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