A5030655439- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Organ Transplantation Techniques and Outcomes
- Complement system in diseases
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Clinical Laboratory Practices and Quality Control
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- Ocular Surface and Contact Lens
- Diabetes Management and Research
- Pancreatic function and diabetes
- Immune Response and Inflammation
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Nutrition and Health Studies
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
Gdańsk Medical University
2013-2024
University Clinical Centre
2020-2022
Here we looked for possible mechanisms regulating the progression of type 1 diabetes mellitus (T1DM). In this disease, autoaggressive T cells (T conventional cells, Tconvs) not properly controlled by regulatory (Tregs) destroy pancreatic islets. We compared T-cell compartment patients with newly diagnosed T1DM (NDT1DM) long-duration (LDT1DM) ones. The third group consisted LDT1DM treated previously polyclonal Tregs (LDT1DM Tregs). have also if differences might be dependent on antigen...
High titer of donor-specific antibodies (DSAs) increases the risk graft rejection after mismatched related hematopoietic cell transplantation (HCT). There are no data regarding incidence anti-HLA recipient-specific (RSAs) and their role transplantation. Here we aimed to identify RSAs in a donor population possible impact on immune-mediated complications, such as acute graft-versus-host disease (aGVHD), complications resulting from endothelial injury, transplantation-associated thrombotic...
Corneal transplantations (CTXs) are a vision-saving procedure. Routinely, while CTXs' survival rates remain high, the risk of graft failure increases significantly for repeated CTXs. The reason is an alloimmunization following previous CTXs and development memory T (Tm) B (Bm) cells.
Kidney transplantation is the treatment of choice for end-stage kidney diseases. Unfortunately, allograft recipients rarely develop tolerance or accommodation and require life-long immunosuppression. Among many other regulatory mechanisms, CD5+ B lymphocytes (mainly B-1a) seem to be involved in process acceptance. These cells are major source natural, low-affinity antibodies, which polyreactive. Thus, we hypothesized that could referred as a biomarker those patients who developed towards...
Introduction: True transplant tolerance is very rare, and the more common process that leads to acceptance of transplanted organ accommodation, or acquired resistance graft rejection despite specific immune. Mediation occurs largely through Tregs Bregs secreting IL-10. Among many subsets, B-1 cells, expressing CD5 antigen are special interest. cells produce antibodies spontaneously, which predominantly IgM, appear naturally even in absence immunization they low affinity polyreactivity. This...
Introduction: Penetrating keratoplasty is a vision-saving procedure. It relatively easy to perform, as it does not require immunological matching, yet the grafts survival rates are high. The risk of graft failure increases in case repeated transplantation. possible reason that alloimmunization and subsequent rejection prime adaptive immune system for next mismatched tissue. process, described generally on mouse model, mediated by CD4+ T cells, however, other populations cells were also...