A5081767330- Pain Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Osteoarthritis Treatment and Mechanisms
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects of Natural Compounds
- Nerve injury and regeneration
- Angiogenesis and VEGF in Cancer
- Autophagy in Disease and Therapy
- Cardiac Fibrosis and Remodeling
- Anesthesia and Pain Management
- Genomics and Chromatin Dynamics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- Biomarkers in Disease Mechanisms
- Advanced Glycation End Products research
- Natural product bioactivities and synthesis
- Peroxisome Proliferator-Activated Receptors
- Ginkgo biloba and Cashew Applications
- Alzheimer's disease research and treatments
- Microtubule and mitosis dynamics
Korea Research Institute of Chemical Technology
2024
Chungnam National University
2019-2023
Korea Research Institute of Bioscience and Biotechnology
2021
Cartilage loss is a central event in the pathogenesis of osteoarthritis (OA), though other than mechanical loading, biochemical mechanisms underlying OA pathology remain poorly elucidated. We investigated role Pink1-mediated mitophagy mitochondrial fission, crucial process pathogenesis. used monosodium iodoacetate (MIA)-induced rodent model OA, which inhibits activity articular chondrocytes, leading to disruption glycolytic energy metabolism and eventual cell death. The rat cartilage...
Osteoarthritis (OA) is the most common joint disorder that has had an increasing prevalence due to aging of population. Recent studies have concluded OA progression related oxidative stress and reactive oxygen species (ROS). ROS are produced at low levels in articular chondrocytes, mainly by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, production been found be elevated patients with OA. The cartilage OA-affected rat exhibits a significant induction p47phox, cytosolic subunit...
Osteoarthritis (OA) is the most common type of joint disease associated with cartilage breakdown. However, role played by mitochondrial dysfunction in OA remains inadequately understood. Therefore, we investigated p66shc during oxidative damage and effects downregulation on progression.Monosodium iodoacetate (MIA), which commonly used to generate animal models, inhibits glycolysis biosynthetic processes chondrocytes, eventually causing cell death. To observe MIA poly(lactic-co-glycolic acid)...
Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced model by inhibiting activation of NF-κB and p38 MAPK pathways microglia. Materials & methods: After NP preparation, miR NPs were assessed for their physical characteristics then injected intrathecally into cords ligation rats to test analgesic effects. Results: reduced 11 days negatively regulating inflammatory response Conclusion: The...
Duloxetine (DLX) encapsulated PLGA nanoparticles were applied intrathecally into the spinal cord of nerve ligation-induced neuropathic pain rats. DLX significantly alleviated behavior by enhanced targeting microglia.
β-Catenin is a multifunctional protein and participates in numerous processes required for embryonic development, cell proliferation, homeostasis through various molecular interactions signaling pathways. To date, however, there no direct evidence that β-catenin contributes to cytokinesis. Here, we identify novel p-S60 epitope on generated by Plk1 kinase activity, which can be found at the actomyosin contractile ring of early telophase cells midbody late cells. Depletion leads...
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of Parkinson's disease (PD). Interestingly, recent studies have reported an increased risk stroke in patients with PD harboring LRRK2 mutations, but there is no evidence showing functional involvement stroke. Here, we found that activity was significantly induced Rose-Bengal (RB) photothrombosis-induced mouse model. infarct volumes were reduced, and neurological deficits diminished by pharmacological inhibition using...
Supplementary Data from COMP-Ang1 Potentiates the Antitumor Activity of 5-Fluorouracil by Improving Tissue Perfusion in Murine Lewis Lung Carcinoma
Supplementary Data from COMP-Ang1 Potentiates the Antitumor Activity of 5-Fluorouracil by Improving Tissue Perfusion in Murine Lewis Lung Carcinoma
<div>Abstract<p>Chemotherapy is often hindered by abnormal tumor vascularity, which causes impaired delivery of drugs into the tumor. Angiopoietin-1 has potent roles in angiogenesis and vessel maturation. We report here that an angiopoietin-1 variant, COMP-Ang1, promotes vascular remodeling pericyte coverage thereby efficient a chemotherapeutic drug tumors murine Lewis lung carcinoma. The combination COMP-Ang1 with cytotoxic 5-fluorouracil potentiated effect on growth without...
<div>Abstract<p>Chemotherapy is often hindered by abnormal tumor vascularity, which causes impaired delivery of drugs into the tumor. Angiopoietin-1 has potent roles in angiogenesis and vessel maturation. We report here that an angiopoietin-1 variant, COMP-Ang1, promotes vascular remodeling pericyte coverage thereby efficient a chemotherapeutic drug tumors murine Lewis lung carcinoma. The combination COMP-Ang1 with cytotoxic 5-fluorouracil potentiated effect on growth without...