A5090534202- Single-cell and spatial transcriptomics
- Muscle activation and electromyography studies
- Advanced Sensor and Energy Harvesting Materials
- Neuroscience and Neural Engineering
- Nerve Injury and Rehabilitation
- Orthopedic Surgery and Rehabilitation
- Congenital heart defects research
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Nerve Disorders
- Mitochondrial Function and Pathology
- Stroke Rehabilitation and Recovery
- Neurogenesis and neuroplasticity mechanisms
University of Michigan
2025
Johns Hopkins University
2023
Wisconsin Institutes for Discovery
2021-2022
University of Wisconsin–Madison
2021-2022
Our inability to derive the neuronal diversity that comprises posterior central nervous system (pCNS) using human pluripotent stem cells (hPSCs) poses an impediment understanding neurodevelopment and disease in hindbrain spinal cord. Here, we establish a modular, monolayer differentiation paradigm recapitulates both rostrocaudal (R/C) dorsoventral (D/V) patterning, enabling derivation of diverse pCNS neurons with discrete regional specificity. First, neuromesodermal progenitors (NMPs) HOX...
Abstract After an amputation, advanced prosthetic limbs can be used to interface with the nervous system and restore motor function. Despite numerous breakthroughs in field, many of recent research advancements have not been widely integrated into clinical practice. This review highlights innovations neuromuscular implants—specifically those that skeletal muscle—which could improve translation technologies. Skeletal muscle provides a physiologic gateway harness amplify signals from system....
Summary Our inability to derive the vast neuronal diversity of posterior central nervous system (pCNS) using human pluripotent stem cells (hPSCs) poses a major impediment understanding neurodevelopment and disease in hindbrain spinal cord. Here we establish modular differentiation paradigm that recapitulates patterning along both rostrocaudal (R/C) dorsoventral (D/V) axes pCNS, enabling derivation any phenotype with discrete regional specificity. First, neuromesodermal progenitors (NMPs) Hox...