A5008419589- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
University of California, Merced
2018-2022
Abstract CD8 T cells can play both a protective and pathogenic role in inflammation autoimmune development. Recent studies have highlighted the ability of to function as follicular helper (Tfh) germinal center context infection. However, whether this phenomenon occurs autoimmunity contributes pathogenesis is largely unexplored. In study, we show that acquire CD4 Tfh profile absence functional regulatory IL-2–deficient scurfy mouse models. Depletion mitigates mice. express B cell...
Abstract IL-2Rα is required to generate the high affinity receptor for IL-2, a cytokine important in immune proliferation, activation, and regulation. Mice deficient (IL-2Rα-KO) develop systemic autoimmune disease die from severe anemia between 18-80 days of age. These mice kinetically differing disease, with approximately quarter dying by 21 age half after 30 days. This research aims define parameters that distinguish cohorts early- late-stage IL-2Rα-KO genetic background. To investigate...