A5018359830- Geological and Geochemical Analysis
- High-pressure geophysics and materials
- Geochemistry and Geologic Mapping
- Venous Thromboembolism Diagnosis and Management
- earthquake and tectonic studies
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Ginseng Biological Effects and Applications
- Acute Ischemic Stroke Management
- Traditional Chinese Medicine Analysis
- Lung Cancer Research Studies
- Vascular Anomalies and Treatments
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Pharmacological Effects of Medicinal Plants
- Pain Mechanisms and Treatments
- Cancer therapeutics and mechanisms
- Geochemistry and Geochronology of Asian Mineral Deposits
- Tracheal and airway disorders
- 14-3-3 protein interactions
Peking University
2012-2025
Peking University Cancer Hospital
2020-2025
Universidad del Noreste
2025
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2023-2024
Ningxia Medical University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2024
Peking Union Medical College Hospital
2008-2024
Beijing Anzhen Hospital
2018-2024
Capital Medical University
2018-2024
Tianjin Municipal Research Institute for Family Planning
2008-2024
Black pepper (Piper nigrum L.) has been commonly utilized in food preparation and traditional medicine several countries. Seven new amide alkaloids, pipernigramides A-G (3, 10, 38, 41-44), a piperic ester, pipernigrester A (48), along with 47 known compounds were isolated from the EtOH extract of P. nigrum. The inhibitory effects on nitric oxide (NO) all then evaluated. Among tested compounds, three them (42-44) significantly inhibited inducible synthase (iNOS)-mediated NO (IC50 = 4.74 ±...
Puerarin was a major isoflavonoid derived from the Chinese medical herb radix puerariae (Gegen). In present study effect of puerarin on cisplatin nephrotoxicity evaluated. Rat model established by single intraperitoneal injection (7mg/kg). administrated through caudal vein once per day at dose 10mg/kg, 30mg/kg and 50mg/kg. Biochemical assays showed that after treatment serum urea creatinine increased significantly compared with control (P<0.05). Cisplatin xanthine oxidase (XO) activity...
A continuous fermentation process has been developed in Pichia pastoris (P. pastoris) with the glyceraldehyde-3-phosphate dehydrogenase (GAP) promoter order to produce large quantities of recombinant human chitinase (rh-chitinase) for preclinical studies as a potential high-dose antifungal drug. Expression levels about 200 400 mg/L have demonstrated fed-batch fermentations using strains either traditional methanol-inducible or constitutive GAP promoter. Proteolytic degradation enzyme was...
Voluminous granite plutons were emplaced in the Late Mesozoic Nanling Range, South China, accompanied by large-scale polymetallic deposits. Most are composite, composed of major-phase granites and highly differentiated late-stage granites. Previous studies have proposed fractionation both types deposits from a common magma. We choose to study ages, chemistry Nd-Hf isotopes Guposhan complex propose different model for origin relationship with associated mineralization Range. The Complex...
In the present study, effects of total flavonoids Rhizoma Drynariae (TFRD) and calcium carbonate (CaCO<sub>3</sub>) on osteoporosis (OP) were assessed in a rat model OP. For this purpose, 36 Sprague‑Dawley rats, aged 3 months, randomly divided into group undergoing sham surgery (sham‑operated group), (OP CaCO<sub>3</sub> + TFRD combined with group) N‑acetyl cysteine NAC group). The OP was established by bilateral ovariectomy. changes bone mineral density (BMD), volume parameters...
MiR-206 was involved in a series of cellular activities, such as the growth and development skeletal muscle tumorigenesis. characterized previously differentially expressed gene sodium arsenite (SA)-induced neural tube defects (NTDs) chick embryos via miRNA microarray analysis. However, role miR-206 pathological process nerve cells remained elusive. In this study we found differential expression SA-treated by Northern blot Ectopic inhibited cell proliferation, promoted apoptosis U343 SK-N-SH...
Cdc20 (cell division cycle 20 homologue) has been reported to exhibit an oncogenic role in human tumorigenesis. However, the function of osteosarcoma (OS) not investigated. In current study, we aim explore OS cells. Multiple approaches were used measure cell growth, apoptosis, cycle, migration and invasion cells after depletion or overexpression Cdc20. We found that down-regulation inhibited induced apoptosis triggered arrest Moreover, let inhibition Consistently, promoted enhanced invasion....
A tight constraint on the closure time of Irtysh–Zaysan Ocean, a major southwestern branch Paleo‐Asian is crucial for understanding final amalgamation Central Asian Orogenic Belt; however, no agreement has been reached. This study presents new zircon U–Pb ages and whole‐rock geochemical data Keluke composite pluton in Zharma–Saur arc northern West Junggar (NW China). The mainly includes hornblende gabbro, gabbroic diorite, K‐feldspar granite. laser ablation inductively coupled plasma mass...
Klisyri (KX01) is a dual tubulin/Src protein inhibitor that has shown potential therapeutic effects in several tumor models. However, phase II clinical trial patients with bone-metastatic castration-resistant prostate cancer was halted because of lack efficacy. We previously reported KX01 binds to the colchicine site β-tubulin and its morpholine group lies close α-tubulin's surface. Thus, we hypothesized enhancing interaction α-tubulin could increase tubulin inhibition synthesized series...