A5053185159- Parkinson's Disease Mechanisms and Treatments
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Restless Legs Syndrome Research
- RNA regulation and disease
- MicroRNA in disease regulation
- Neurological disorders and treatments
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Ginkgo biloba and Cashew Applications
- Genomics and Rare Diseases
- Conducting polymers and applications
- Nuclear Receptors and Signaling
- Multiple and Secondary Primary Cancers
- Cancer-related molecular mechanisms research
Universitat Autònoma de Barcelona
2021-2025
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2021-2025
Hospital Universitari Germans Trias i Pujol
2023-2025
Institut Català d'Oncologia
2023
Institut d'Investigació Biomédica de Bellvitge
2023
The use of saliva as a biomarker source has advantages over other biofluids and imaging techniques, miRNAs are ideal candidates. They involved in numerous cellular processes, their altered expression suggests that play crucial regulatory role disease development. We wanted to find an easily reproducible executable miRNA-obtaining methodology suitable for quantification. Three commercial miRNA extraction kits (mirVana, Nucleospin miRNeasy) three collectors (50 mL tubes, Salimetrics Oragene)...
Neoadjuvant treatment (NAT) is one of the most widely used options for HER2+ and triple negative (TN) early breast cancer (BC). Since around half patients treated with NAT do not achieve a pathologically complete response (pCR), biomarkers to predict resistance are urgently needed. The correlation clinicopathological factors pCR was studied in 150 (HER2 = 81; TN 69) pre- post-NAT differences tumour were compared. Low estrogen receptor (ER) expression, high tumour-infiltrating lymphocytes...
Abstract Motivation Germline variant classification allows accurate genetic diagnosis and risk assessment. However, it is a tedious iterative process integrating information from several sources types of evidence. It should follow gene-specific (if available) or general updated international guidelines. Thus, the main burden incorporation next-generation sequencing into clinical setting. Results We created vaRiants in HC (vaRHC) R package to assist hereditary cancer by: (i) collecting...
Lewy body diseases (LBD) including dementia with bodies (DLB) and Parkinson disease (PD) are characterized by alpha-synuclein pathology. DLB is difficult to diagnose peripheral biomarkers urgently needed. Therefore, we analyzed the expression of five gene (SNCA) transcripts, SNCAtv1, SNCAtv2, SNCAtv3, SNCA126, SNCA112, in 45 LBD control temporal cortex samples blood 72 DLB, 59 PD, 54 subjects. The results revealed overexpression SNCAtv1 SNCA112 SNCAtv2 PD cortices. In blood, diminution all...
The highest prevalence of MSI is observed in colorectal (CRC), endometrial, and gastric cancers. Lately, has expanded its clinical utility as predictive biomarker to immunotherapy (IO). IHC and/or PCR are the gold standard methods for detection, though NGS arises a promising approach expand spectrum malignancies which we can detect dMMR or MSI-H. We performed multicentric retrospective study adult pt with advanced solid evaluated through coordinated MPP at three different Catalan Institute...