A5037574015- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Photochemistry and Electron Transfer Studies
- Analytical Chemistry and Sensors
- Luminescence and Fluorescent Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Molecular Sensors and Ion Detection
- Infection Control and Ventilation
- Free Radicals and Antioxidants
- Crystallography and molecular interactions
- Lipid Membrane Structure and Behavior
- Spectroscopy and Quantum Chemical Studies
- Quantum Dots Synthesis And Properties
- Supramolecular Chemistry and Complexes
- Corneal surgery and disorders
- Advanced Photocatalysis Techniques
- COVID-19 and healthcare impacts
- Photochromic and Fluorescence Chemistry
- Dental Research and COVID-19
- Electrochemical Analysis and Applications
- Supramolecular Self-Assembly in Materials
- Antimicrobial agents and applications
University of Calgary
2016-2025
Calgary Laboratory Services
2015-2019
University of Ottawa
2006-2011
University of Liège
2003-2006
Wilfrid Laurier University
2006
To dye for: Three related families of fluorescent dyes, rigidified by boron difluoride and based on bidentate anilido-pyridyl donor ligands, are reported (see picture). The dyes show quantum yields up to 0.75 improved Stokes shifts >100 nm relative the widely employed BODIPY family dyes. Furthermore, new exceptionally photostable membrane-specific. Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset....
Abstract For decades lysophosphatidylcholine (LPC, lysolecithin) has been used to induce demyelination, without a clear understanding of its mechanisms. LPC is an endogenous lysophospholipid so it may cause demyelination in certain diseases. We investigated whether known receptor systems, inflammation or nonspecific lipid disruption mediates LPC‐demyelination mice. found that nonspecifically disrupted myelin lipids. integrated into cellular membranes and rapidly induced cell membrane...
Herein, we synthesized a series of 10 core–shell silver–silica nanoparticles with photosensitizer, Rose Bengal, tethered to their surface. Each nanoparticle possesses an identical silver core about 67 nm, but presents different silica shell thickness ranging from 5 100 nm. These hybrid plasmonic thus afford nanostructure platform source singlet oxygen (1O2) at well-defined distance the metallic core. Via time-resolved and steady state spectroscopic techniques, demonstrate exerts dual role...
Plasmonic nanoparticles can strongly interact with adjacent photosensitizer molecules, resulting in a significant alteration of their singlet oxygen (1O2) production. In this work, we report the next generation metal-enhanced 1O2 nanoplatforms exploiting lightning rod effect, or plasmon hot spots, anisotropic (nonspherical) metal nanoparticles. We describe synthesis Rose Bengal-decorated silica-coated silver nanocubes (Ag@SiO2-RB NCs) silica shell thicknesses ranging from 5 to 50 nm based on...
Microbiological metal toxicity involves redox reactions between species and cellular molecules, therefore, we hypothesized that antioxidant systems might be chromosomal determinants affecting the susceptibility of bacteria to toxicity. Here, survival was quantified in ion-exposed planktonic cultures several Escherichia coli strains, each bearing a mutation gene important for homeostasis. This characterized approximately 250 gene-metal combinations identified sodA, sodB, gor, trxA, gshA, grxA...
The unexpected interaction between thiazole orange (TO) and calix[4]arene sulfonate is reported herein. H-Aggregates of TO switching on their fluorescence in solution are observed. Surprisingly, enhancement not linked to host-guest inclusion, but rather serving as a template for several molecules.
In aqueous electrochemical processes, the pH evolves spatially and temporally, often dictates process performance. Herein, a new method for in-operando monitoring of distribution in an cell is demonstrated. A combination pH-sensitive fluorescent dyes, encompassing wide range from ≈1.5 to 8.5, rapid electrochemically coupled laser scanning confocal microscopy used observe changes cell. Using electrocoagulation as example process, we show that provides insights into reaction mechanisms. The...
It is uncommon to read about cyanine dyes in the literature and not have their aggregation discussed. They are of high interest considering propensity undergo self-organization aqueous solution, leading interesting photophysical properties resulting from formation dimers higher ordered aggregates. Currently, study demand due diverse application range including dye-sensitized solar cells. However, salt solutions under studied, effect on congruence with ionic strength often overlooked. In a...
Neue Farben: Über drei verwandte Fluoreszenzfarbstoffklassen, die durch eine Bordifluorid-Gruppe starr sind und aus zweizähnigen Anilidopyridylliganden bestehen (siehe Bild), wird berichtet. Die Farbstoffe zeigen Quantenausbeuten bis 0.75 mehr als 100 nm stärkere Stokes-Verschiebung BODIPY-Farbstoffe. Zudem sie außergewöhnlich photostabil membranspezifisch.
In plasmon-enhanced singlet oxygen (1O2) production, irradiation of a hybrid photosensitizer-metal nanoparticle leads to significant alteration the photosensitizer's 1O2 yield. The quest for more rational design these nanomaterials calls better understanding enhancement mechanism that, this day, remains largely unexplored. Herein, we introduce new methodology distinguish near- and far-field contributions production using tunable model nanoplatform, Rose Bengal-decorated silica-coated metal...
The coronavirus disease 2019 (COVID-19) pandemic has resulted in shortages of personal protective equipment (PPE), underscoring the urgent need for simple, efficient, and inexpensive methods to decontaminate masks respirators exposed severe acute respiratory virus 2 (SARS-CoV-2). We hypothesized that methylene blue (MB) photochemical treatment, which various clinical applications, could PPE contaminated with coronavirus.The arms study included (1) inoculation coronaviruses followed by MB...
Endocrine disrupting chemicals are adversely affecting the reproductive health and metabolic status of aquatic vertebrates. Estrone is often dominant natural estrogen in urban sewage, yet little known about its environmental fate biological effects. Increased use UV-B radiation for effluent treatments, exposure effluents to sunlight holding ponds led us examine effects environmentally relevant levels on photodegradation potential estrone. Surprisingly, mediated degradation leads...
Abstract Studies involving metal enhancement effects have gained popularity, and of fluorescence due to the close proximity a dye molecule nanoparticle is well documented. Although singlet oxygen production by has been reported, studies are relatively scarce so far only stationary silver island films proven be adequate do so. Herein, we describe synthesis characterization core–shell nanoparticles on which photosensitizer acting as source covalently attached surface. As proof concept, with...
Working with silica nanoparticle encapsulated BODIPY and xanthene photosensitizers, we have determined that singlet oxygen spends up to 78% of its lifetime inside the nanocarriers. Our systematic investigation indicates hydrophobicity rules photosensitizer distribution in nanoparticles, which turn dictates ability these structures release oxygen.
The effect of changing acceptor strength on intramolecular charge transfer absorption and its implication towards organic materials are investigated.
Abstract Various technological and biomedical applications rely on the ability of materials to emit light (photoluminescence [PL]), and, among them, metal nanoparticles (NPs) semi-conductor Quantum Dots (QDs) represent ideal candidates as sensing probes imaging tools, portraying better PL features than conventional organic dyes. However, knowledge behavior semiconductor NPs – i.e., selenium; SeNPs is still in its infancy, especially for those synthesized by microorganisms. Considering...
Understanding the role played by external factors on organization of molecules has potential to contribute greatly fundamental research and applications in fields as diverse nanotechnology, medicine, material chemistry, etc. Countless studies involve small organic environments rich ionic species, yet their participation molecular is often overlooked. Herein, we critically assess aqueous solution cationic cyanine dye, thiazole orange, presence different monovalent sodium salts. Our findings...
Oncolytic virus (OV) therapy is an emerging cancer treatment that uses replicating viruses to infect and kill tumor cells incite anticancer immunity. While the approach shows promise, it currently fails most patients, indicating strategies improve OV activity are needed. Developing these will require greater understanding of biology, particularly in context delivery clearance, infection process within a complex microenvironment, modulation To help achieve this, we have established technique...