A5019758216- Phytochemistry and Biological Activities
- Eicosanoids and Hypertension Pharmacology
- Renal and Vascular Pathologies
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Ethnobotanical and Medicinal Plants Studies
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Botanical Research and Applications
- Synthesis and biological activity
- Ion Transport and Channel Regulation
- Crystallization and Solubility Studies
- Phytochemicals and Antioxidant Activities
- Traditional and Medicinal Uses of Annonaceae
- Hormonal Regulation and Hypertension
- X-ray Diffraction in Crystallography
- Nitric Oxide and Endothelin Effects
- Renal function and acid-base balance
- MRI in cancer diagnosis
- Psidium guajava Extracts and Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Bioactivity Studies
- Renin-Angiotensin System Studies
- Seed and Plant Biochemistry
- Genetic and Kidney Cyst Diseases
Universidad Técnica Particular de Loja
2016-2025
Universidad Nacional Autónoma de México
2014-2017
Instituto Nacional de Investigación en Salud Pública
2017
Mayo Clinic
1988-2007
Mayo Clinic in Arizona
2000-2003
WinnMed
1990-2002
Mayo Clinic in Florida
2000
Research Institute Hospital 12 de Octubre
1988
Northwestern University
1988
University of Michigan
1972-1974
The traditional markets in southern Ecuador and within the Andean region are especially important for plant resource trading among local people, even since before Spanish colonization; therefore, ethnobotanical studies currently necessary important. These strategic spaces persist medicine cultural value reflected higher consumption of medicinal plants, which span all socioeconomic levels rural urban people. purpose this study includes following: 1) to create a novel list plants sold at 33...
The "horchata" is a herbal mixture infusion consumed in Southern Ecuador. It remains unknown how vendors group the plant species to sell them at traditional markets. This research documented following: 1) list of medicinal sold for drink; 2) culturally important species; 3) agreement among regarding plants and their therapeutic use; 4) groups preparation "horchata." Interviews were made 185 31 markets Loja province. Bunches purchased identify prepare voucher specimens. Culturally established...
Eight Schiff bases, synthesized by the reaction of 4-aminoantipyrine with different cinnamaldehydes, were studied in solid state using vibrational spectroscopy (IR) and X-ray diffraction techniques. The analysis was extended to solution phase through ultraviolet-vis, fluorescence spectroscopy, cyclic voltammetry. Finally, crystal structures four compounds (3b, 3d, 3g, 3h) determined studied. In addition experimental study, theoretical calculations semiempirical method PM6/ZDO performed...
The authors examined the utility of cine computerized tomography (CT) for noninvasive determination whole kidney, cortical, and medullary volumes. right kidneys 14 anesthetized dogs were scanned after an intravenous bolus injection iohexol, their volumes determined boundary identification. After scans, excised at postmortem examination by fluid displacement. mean (± standard error [SEM]) in vivo renal 66.1 ± 2.2 cc 78.2 2.4 cc, respectively (r = 0.86; P < 0.001). difference was consistent...
Abstract The three‐dimensional architecture of nephrons in situ and their interrelationship with other are difficult to visualize by microscopic methods. present study uses microcomputed X‐ray tomography (micro‐CT) intact situ. Rat kidneys were perfusion‐fixed buffered formalin vasculature was subsequently perfused radiopaque silicone. Cortical tissue stained en bloc osmium tetroxide, embedded plastic, scanned, reconstructed at voxel resolutions 6, 2, 1 μm. At 6 μm resolution, large blood...
Abstract Background Pyrazoles have attracted particular attention due to the diverse biological activities associated with this heterocyclic system, and some been shown be cytotoxic several human cell lines. Several drugs currently on market heterocycle as key structural motif, approved for treatment of different types cancer. Results 4,4ʹ-(Arylmethylene)bis(1 H -pyrazol-5-ols) derivatives 3a – q were synthetized by a three components reaction 3-methyl-1-phenyl-5-pyrazolone ( 1 ) various...
Vasconcellea, the most abundant genus within Caricaceae family, encompasses twenty-one out of 35 species in predominantly found Peru, Ecuador, and Colombia, where they are utilized for both culinary medicinal purposes. This study investigates research trends, patents, nutritional functional potential three native Ecuadorian genus: Vasconcellea stipulata V.M. Badillo (toronche), pubescens (V.M. Badillo) (chamburo), their natural hybrid x pentagona (babaco). Utilizing bibliometric analysis via...
Geranium diffusum Kunth is a medicinal plant native to Ecuadorian highlands with limited scientific study despite its ethnopharmacological relevance. The present investigates the phytochemical properties and cytotoxic effects of methanolic extract G. diffusum. Comprehensive analyses revealed rich composition bioactive compounds, predominantly flavonoids rutin, isoquercetin, isorhamnetin-3-glucoside, known for their therapeutic potential, were isolated. solvent fractions evaluated activity...
Background and Aim: Breast cancer is one of the most prevalent lethal malignancies affecting women worldwide. Given limitations conventional treatments, there an increasing interest in exploring naturally derived compounds with chemoprotective properties. Purple sweet potatoes (Ipomoea batatas L.) are rich anthocyanins have been reported to possess antioxidant, anti-inflammatory, anticancer activities. This study aimed evaluate chemopreventive potential ethanolic extracts from purple potato...
Pulverized immature fruits of Annona montana M. are commonly used for biomedical applications, especially in the treatment dysentery. The aim this study was to investigate whether hexane, ethyl acetate or methanol extracts A. can be cytotoxic human tumor cells exhibit genotoxic effects on normal cells. organic were shown inhibit survival originating from astrocytoma, breast, colon, lung and prostate cancers. Furthermore, they found induce DNA damage lymphocytes, as by comet assay. observed...
The species Chenopodium quinoa Willd. and Amaranthus hybridus L. are Andean staples, part of the traditional diet gastronomy people highlands Colombia, Ecuador, Peru, Bolivia, northern Argentina Chile, with several ethnopharmacological uses, among them anticancer applications. This review aims to present updated information on nutritional composition, phytochemistry, antimicrobial activity Quinoa Amaranth. Both contribute food security due their essential amino acid contents, which higher...
"Horchata" is an herbal mixture infusion consumed in Southern Ecuador; 66% of its plants are anti-inflammatory medicinal plant, and 51% analgesics. Anti-inflammatory substances can prevent carcinogenesis mediated by cytotoxic effects DNA damage. The aim this study was to evaluate the cytotoxicity apoptotic/antigenotoxic horchata as well mechanism. Nine different varieties were prepared traditional way then freeze-dried. Phytochemical screening tested for presence secondary metabolites using...
Some species of the Clusia genus have been shown to important biomedical properties, including ability inhibit tumor growth in vitro and usefulness for skin care. In this study, we examined cytotoxic effect hexane, ethyl acetate methanol extracts from latipes Planch. & Triana, Clusiaceae, leaves on survival human prostate cancer cells (PC-3), colon (RKO), astrocytoma (D-384), breast (MCF-7). The extract displayed most substantial effect. However, using a Comet assay, observed that hexane...
A peptide converting enzyme inhibitor given intravenously to rabbits was shown abolish the pressor response injections of rabbit renin and angiotensin-I augment depressor bradykinin. In with acute two-kidney Goldblatt hypertension (2-KGH [one renal artery clamped, other intact]) a total dose 36 mg/kg infused for one hour lowered blood pressure but not normal level. One week after removal intact kidney (acute one-kidney [1-KGH]) infusions were still antihypertensive. Thirty 60 days (chronic...