A5065701759- Enzyme Structure and Function
- Advanced Proteomics Techniques and Applications
- Web Data Mining and Analysis
- Mathematics, Computing, and Information Processing
- Natural Language Processing Techniques
- Advanced Synthetic Organic Chemistry
- Computational Drug Discovery Methods
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Topic Modeling
- Protein Structure and Dynamics
- Mass Spectrometry Techniques and Applications
- Bacterial Genetics and Biotechnology
- Microbial Natural Products and Biosynthesis
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
Laboratoire d'Innovation Thérapeutique
2021-2024
Université de Strasbourg
2021-2024
Centre National de la Recherche Scientifique
2021
Nanyang Technological University
2019
New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination sodium hydride (NaH) and zinc halides (ZnX2 ). Use different halide on ZnX2 dictates the selectivity, wherein NaH-ZnI2 system delivers NaH-ZnCl2 gives amines. Extensive mechanistic studies by experimental theoretical approaches imply that polymeric (ZnH2 )∞ is responsible alcohol formation, whereas dimeric chloride (H-Zn-Cl)2 key species production
Screening of fragment libraries is a valuable approach to the drug discovery process. The quality library one keys success, and more particularly design or choice has meet specificities research program. In this study, we made an inventory commercial established methodology which allows any be positioned in relation complete offer currently on market, by addressing following questions: does chemical look like another library? What coverage current space are characteristic structural features...
Abstract Aminoglycosides are crucial antibiotics facing challenges from bacterial resistance. This study addresses the importance of aminoglycoside modifying enzymes in context escalating Drawing upon over two decades structural data Protein Data Bank, we focused on key antibiotics, neomycin B and kanamycin A, to explore how structure is exploited by this family enzymes. A systematic comparison across diverse RNA A‐site target identified common characteristics recognition mode, while...
The fragment approach has emerged as a method of choice for drug design, it allows difficult therapeutic targets to be addressed. Success lies in the screened chemical library and biophysical screening method, also quality selected structural information used develop drug-like ligand. It recently been proposed that promiscuous compounds, i.e., those bind several proteins, present an advantage because they are likely give frequent hits screening. In this study, we searched Protein Data Bank...
Abstract New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination sodium hydride (NaH) and zinc halides (ZnX 2 ). Use different halide on ZnX dictates the selectivity, wherein NaH‐ZnI system delivers NaH‐ZnCl gives amines. Extensive mechanistic studies by experimental theoretical approaches imply that polymeric (ZnH ) ∞ is responsible alcohol formation, whereas dimeric chloride (H−Zn−Cl) key species production