A5002465414- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Prosthetics and Rehabilitation Robotics
- Neuroscience and Neural Engineering
- Stroke Rehabilitation and Recovery
- Malaria Research and Control
- Spinal Cord Injury Research
- Modular Robots and Swarm Intelligence
- Advanced Sensor and Energy Harvesting Materials
- Soft Robotics and Applications
- Robot Manipulation and Learning
- Computational Drug Discovery Methods
- Gastrointestinal disorders and treatments
- Psychedelics and Drug Studies
- Traditional and Medicinal Uses of Annonaceae
- Research on Leishmaniasis Studies
- Education and Digital Technologies
- vaccines and immunoinformatics approaches
- Engineering Technology and Methodologies
- Mass Spectrometry Techniques and Applications
- Synthesis and Biological Activity
- Trypanosoma species research and implications
- Balance, Gait, and Falls Prevention
- Business and Management Studies
- Tumors and Oncological Cases
Griffith University
2021-2023
Universitat Politècnica de Catalunya
2023
Universidade Estadual do Norte do Paraná
2022
University of Cape Town
2020-2021
Universidade de Brasília
2014-2021
Technische Universität Berlin
2018
Universidade Estadual do Oeste do Paraná
2007-2014
Universidade Estadual de Campinas (UNICAMP)
2013
Abstract Malaria remains a major public health problem. With the loss of antimalarials to resistance, malaria burden will likely continue for decades. New antimalarial scaffolds are crucial avoid cross-resistance. Here, we present first structure based virtual screening using β-haematin crystal as target new inhibitor by applying docking method. The ZINC15 database was searched compounds with high binding affinity surface PyRx Virtual Screening Tool. Top-ranked predicted interact were...
Physical exercise may produce significant systemic benefits including reducing the risk of cardiovascular diseases. For individuals with spinal cord injury (SCI), muscles that are not volitionally contracted can be activated using functional electrical stimulation (FES), a technology where low-energy electric impulses applied to restore motor function. In this article, we share our experience in developing system, Empowering Mobility and Autonomy (EMA) tricycle, enable persons paraplegia...
The discovery and development of multistage antimalarial drugs targeting intra-erythrocytic asexual sexual Plasmodium falciparum parasites is utmost importance to achieve the ambitious goal malaria elimination. Here, we report validation naphthylisoquinoline (NIQ) alkaloids their synthetic analogues as active drug candidates. A total 30 compounds were tested, which 17 exhibited IC50 values <1 μM against drug-sensitive P. (NF54 strain); 15 these retained activity a panel drug-resistant...
Although advances in technology promoted new physiotherapy approaches for rehabilitation, there is still an urge equipment and techniques to improve quality of life patients with motor disabilities. Functional Electrical Stimulation Cycling (FES Cycling) example this type technology, which we control stimulation parameters enable a spinal cord injured person ride bicycle. The presented research proposes detailed musculoskeletal platform using OpenSim test develop strategies. With platform,...
Recorded electromyograms (EMG) of electrically stimulated muscles can contain both an exogenous-evoked potential (M-wave) and endogenous, or volitional, component. This study evaluated the effectiveness three filtering methods (i.e., high-pass, adaptive, comb), commonly used in neurorehabilitation, extracting volitional component simulated experimental EMG during upper-limb tasks. Volitional M-wave were through a physiological model muscle recruitment, comprising motor neuron pool associated...
Medical device regulatory standards are increasingly incorporating computational modelling and simulation to accommodate advanced manufacturing personalization. We present a method for robust testing of engineered soft tissue products involving digital twin paradigm in combination with robotic systems. developed validated framework calibrating controlling robotic-biological A forward dynamics model the manipulator was developed, calibrated, validated. After calibration, accuracy reproducing...
With the continued loss of antimalarials to resistance, drug repositioning may have a role in maximising efficiency and accelerating discovery new antimalarial drugs. Bayesian statistics was previously used as tool virtually screen USFDA approved drugs for predicted β-haematin (synthetic haemozoin) inhibition vitro activity. Here, we report experimental evaluation nine highest ranked drugs, confirming accuracy model by showing an overall 93% hit rate. Lapatinib, nilotinib, lomitapide showed...
FES-assisted cycling has been recommended to people struggling emerge from a disability more functioning life after spinal cord injury. Recommendations issued by gowing number of scientific papershas promised toimprove body composition and physical activity levels, as well controlinvoluntary muscle response; favoring participation which break new grounds in expanding locomotion, leisure occupational options for with paraplegia tetraplegia. In this report we described our experience select...
Lower-limb rehabilitation for spinal cord injury (SCI) and other motor disorders is often a lengthy process the patient. The combination of active orthoses functional electrical stimulation (FES) promises to accelerate therapy outcome, while simultaneously reducing physical burden therapist. In this work, we propose controller hybrid neuroprosthesis (HNP) composed hip orthosis FES-controlled knee motion. our simulation analysis using detailed musculoskeletal model, use experimental data from...
A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During lead optimization, several issues were flagged such as cross-resistance multidrug-resistant K1 strain, in vitro cytotoxicity, and cardiotoxicity addressed through structure-activity structure-property relationship studies....
Control systems for human physiotherapy exercises based on functional electrical stimulation (FES) have provided excellent performance in several setups. Myocontrolled neuro-prostheses use electromyography (EMG) timing and intensity control of applied to these exercises, estimating not only the volitional activity (from patient) but also evoked FES). A typical EMG response FES starts with artifact, followed by an excitation curve called M-wave. To extract components, we first need find...
It is still a challenge to delay the onset of fatigue on muscle contraction induced by Functional Electrical Stimulation (FES). We explored use two stimulation methods with same total area, single electrode (SES), and spatially distributed electrical (SDSS) during isometric knee extension spinal cord injured (SCI) volunteers. applied left right quadriceps SCI participants both recorded force evoked electromyography (eEMG). calculated force-time integral (FTI) eEMG-time (eTI) for each series...
Functional Electrical Stimulation (FES) may be used in rehabilitation and assistance of people with Spinal Cord Injury (SCI). One significant application is facilitating physical exercise, mainly when combining FES mechanical platforms, such as tricycles. However, there are still technical challenges cycling protocols, improving control performance. Here we show how passive elements knee orthoses during could increase the average cadence, taking advantage movement. Our approach twofold....
Although advances in technology promoted new physiotherapy approaches, there is still an urge for equipment and techniques to improve the quality of patients lives with motor disabilities. Functional electrical stimulation cycling (FES cycling) example this type technology, which control parameters enables a spinal cord injured person ride bicycle. In work, we aim investigate use passive knee orthoses FES assistance. Hence, compared cadence quadriceps excitation using simulation platform...
Pipeline inspections are essential for an updated diagnosis in Oil and Gas Industry, but manual inspection remote areas implies great expenses the long term. Therefore, this process optimization requires autonomous versatile systems, such as Self-reconfigurable Modular Robots (SMR). The SMR machines with variable morphology, therefore they have potential to deal kind of problem. Reorganizing its parts connectivities, offer major flexibility tolerance failure a low cost. This work aims...