A5092662052- Pluripotent Stem Cells Research
- Renal and related cancers
- RNA Research and Splicing
- Pharmacological Effects of Natural Compounds
- Zebrafish Biomedical Research Applications
- Drug-Induced Hepatotoxicity and Protection
- Vitamin C and Antioxidants Research
University of Oxford
2023-2025
Summary During mouse gastrulation, extraembryonic mesoderm (ExEM) contributes to the yolk sac (YS) and allantois, both of which are essential for successful gestation. Although genetic networks coordinating intra-embryonic mesodermal subtype specification well-studied, mechanisms driving ExEM diversification poorly understood. Here, we reveal that embryoid body in vitro differentiation generates two distinct lineages cells matching YS allantois respectively. Combining models with vivo...
The T-box transcription factor Eomesodermin (Eomes), also known as Tbr2, plays essential roles in the early mouse embryo. Loss-of-function mutant embryos arrest at implantation due to Eomes requirements trophectoderm cell lineage. Slightly later, expression visceral endoderm promotes anterior formation and anterior-posterior axis specification. Early induction epiblast beginning day 6 is necessary for nascent mesoderm undergo epithelial mesenchymal transition (EMT). acts a temporally...