Scientific Coordinator, Adult ADHD Research Program; Massachusetts General Hospital; Cambridge,

Attention-deficit/hyperactivity disorder (ADHD) in adulthood is a prevalent, distressing, and impairing condition that not fully treated by pharmacotherapy alone lacks evidence-based psychosocial treatments.To test cognitive behavioral therapy for ADHD adults with medication but who still have clinically significant symptoms.Randomized controlled trial assessing the efficacy of 86 symptomatic were already being medication. The study was conducted at US hospital between November 2004 June...

<h3>Context</h3> Previous studies have reported hypofunction, structural abnormalities, and biochemical abnormalities of the dorsal anterior midcingulate cortex (daMCC) in attention-deficit/hyperactivity disorder (ADHD). Stimulant medications are effective treatments for ADHD, but their neural effects not been fully characterized. <h3>Objective</h3> To determine whether methylphenidate hydrochloride osmotic-release oral system (OROS) would increase functional magnetic resonance imaging...

A growing body of research suggests that deficient emotional self-regulation (DESR) is prevalent and morbid among patients with attention deficit hyperactivity disorder (ADHD). Family studies provide a method clarifying the co-occurrence clinical features, but no family have yet addressed ADHD DESR.Participants were 83 probands without 128 siblings. All assessed for axis I DSM-IV conditions structured diagnostic interviews. The authors defined DESR in adult siblings using items from Barkley...

Deficient emotional self-regulation (DESR) is characterized by deficits in self-regulating the physiological arousal caused strong emotions. We examined whether a unique profile of Child Behavior Checklist (CBCL) would help identify DESR children with attention-deficit/hyperactivity disorder (ADHD).Subjects included 197 ADHD and 224 without ADHD. defined if child had an aggregate cut-off score > 180 but < 210 on Anxiety/Depression, Aggression, Attention scales CBCL (CBCL-DESR). This was...

We examined whether severity scores (1 SD vs 2 SDs) of a unique profile the Child Behavior Checklist (CBCL) consisting Anxiety/Depression, Aggression, and Attention (AAA) scales would help differentiate levels deficits in children with attention-deficit hyperactivity disorder (ADHD).Subjects were 197 ADHD 224 without ADHD. defined deficient emotional self-regulation (DESR) as an aggregate cutoff score >180 but <210 SD) on AAA CBCL (CBCL-DESR) Severe Dysregulation ≥210 same (CBCL-Severe...

Objective: To evaluate the association between attention-deficit/hyperactivity disorder (ADHD) and eating disorders in a large adolescent population of girls with without ADHD. Method: We estimated incidence lifetime (either anorexia or bulimia nervosa) using Cox proportional hazard survival models. Comparisons ADHD were then made on measures comorbidity, course ADHD, growth puberty. Results: 3.6 times more likely to meet criteria for an throughout follow-up period compared control females....

We conducted a 3-phase, double-blind, placebo-controlled, parallel study design of osmotic-release oral system (OROS)-methylphenidate (MPH) in adults (19-60 years age) with attention deficit/hyperactivity disorder as classified by the Diagnostic and Statistical Manual Mental Disorders, Fourth Edition. Phase 1 was 6-week, acute efficacy trial (n = 223), phase 2 24-week, double-blind continuation responders 96), 3 4-week discontinuation 23). The mean daily dosage at endpoint 78.4 ± 31.7 mg...

Article Abstract Objective: We sought to confirm previously documented findings that individuals with attention-deficit/hyperactivity disorder (ADHD) demonstrate impaired driving behavior when compared controls. Method: Subjects were adults (N = 26) and without 23) DSM-IV ADHD ascertained through clinical referrals an adult program advertisements in the local media. Driving was assessed usingthe Manchester Behavior Questionnaire (DBQ) 10 questions from a history questionnaire....

Article AbstractBackground: Impulsivity is a common feature of attention-deficit/hyperactivity disorder (ADHD), and evidence suggests that impulsivity traits may be an indicator poor prognosis for individuals with bulimia nervosa. To identify whether there association between ADHD nervosa, the authors systematically examined data from children adults without ADHD. Method: We identified rates nervosa in (DSM-III-R criteria) our 2 large pediatric adult samples (N = 522 children, 742 adults)....

Article AbstractObjective: To examine whether sleep impairment is associated with attention-deficit/hyperactivity disorder (ADHD) in adults. Method: In a study conducted from 1998 to 2003, we identified characteristics community sample of 182 cases DSM-IV ADHD or not otherwise specified and 117 non-ADHD controls aged 18 55 years. Attention-deficit/hyperactivity status, current lifetime psychiatric comorbidity, pharmacologic treatment were the Structured Clinical Interview for modules...

Attention-deficit hyperactivity disorder (ADHD) is linked to the presence of motor deficiencies, including balance deficits. The cerebellum serves as an integrative structure for control and also involved in cognition, timing anticipatory regulation. Cerebellar development may be delayed children adolescents with ADHD, inconsistent reaction time commonly seen ADHD. We hypothesized that dynamic deficits would present ADHD they correlate attention cerebellar functions.Sixty-two no other...

It is now estimated that attention deficit-hyperactivity disorder (ADHD) afflicts at least 4% of adults in the United States and associated with high levels morbidity functional impairment. One key area dysfunction ADHD impaired motor vehicle operation. Our goal was to examine association between specific driving outcomes a sample using simulator. Subjects were 20 full DSM-IV 21 controls without equal gender distribution. However, mean age subjects somewhat older. All analyses adjusted for...

We examined the prevalence and clinical characteristics of oppositional defiant disorder (ODD) in a sample clinically referred adults with attention deficit hyperactivity (ADHD). Subjects were consecutively DSM-III R/IV diagnosis ADHD or without ODD. Nearly half subjects (43%) had history childhood ODD increased risk for bipolar disorder, multiple anxiety disorders, substance use disorders relative to concluded, as children ODD, have high rates psychiatric comorbidity more impaired...

Clinical trials have demonstrated that pharmacotherapies can safely treat attention-deficit/hyperactivity disorder (ADHD) in adulthood. Eligibility criteria these may significantly limit their external validity by excluding a significant portion of adults with ADHD the general population. In particular, exclusion frequently exclude individuals comorbid mental health conditions, which are common adult population.We addressed representativeness clinical comparing 146 trial participants DSM-IV...

Objectives. Available pharmacotherapies treat some adults with ADHD inadequately. A small literature suggests that glutamate modulation could have effects on ADHD. Methods. Memantine, an N‐methyl‐d‐aspartate (NMDA) receptor antagonist, was titrated to a maximum dose of 10 mg BID in 34 adult subjects aged 18–55 who met DSM-IV criteria for or NOS structured interview. Twenty-eight completed 12 weeks exposure. The Adult Investigator Symptom Report (AISRS), Clinical Global Impression (CGI),...