A5101784345- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Ear Surgery and Otitis Media
- Mast cells and histamine
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Sarcoma Diagnosis and Treatment
- Ear and Head Tumors
- Microgrid Control and Optimization
- Bone Tumor Diagnosis and Treatments
- Vascular Tumors and Angiosarcomas
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Extracellular vesicles in disease
- Otitis Media and Relapsing Polychondritis
- Nanoplatforms for cancer theranostics
- Head and Neck Surgical Oncology
- Phagocytosis and Immune Regulation
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Oral and Maxillofacial Pathology
University of California, San Diego
2025
Longgang Central Hospital
2020-2024
LAMP2 is a ubiquitously expressed protein critical for autophagy. Alternative splicing gives rise to three isoforms. However, the roles of major isoforms in heart are not known. To address this knowledge gap, we generated lamp2a and lamp2b knockout (KO) mice investigate role these function Deletion either Lamp2a or Lamp2b did alter cardiac structure function. Lack all led increased fibrosis reduced survival during pressure overload, which were observed KO mice. Also, LAMP2B loss affect...
Objective To explore the regulation of microRNA-29a (miR-29a) on FOS in human nasal epithelial cells and its molecular mechanism, as well effects miR-29a cell proliferation apoptosis. Methods By transfection, gene silencing, quantitative real-time polymerase chain reaction (qRT-PCR), flow cytometry TUNEL assay (for apoptosis), CCK-8 proliferation), dual-luciferase reporter Western Blot, it was validated that promoted inhibited their apoptosis by down-regulating expression RPMI2650 HNEpC...
We retrospectively analyzed the diagnosis and treatment process of one patient with recurrent undifferentiated pleomorphic sarcoma (UPS) infratemporal fossa made a definite by combining imaging pathological examination results. After failure 2 cycles chemotherapy several surgeries, UPS was eventually treated surgery + carbon ion radiotherapy, MRI reexamination showed no relapse. Head neck is located deeply, easily recurs after operation, difficult to be resected completely surgery, gradually...
Objective:To investigate the feasibility and clinical effect of surgical approach method transnasal fenestration under nasal endoscope for treatment maxillary odontogenic cyst. Methods:The data 23 cases with cysts treated by endoscopy through were retrospectively analyzed. All underwent CT examination before operation. The mucosal membrane parietal wall cyst was excised base. fluid removed decompression, bony opening base trimmed enlarged to edge intraoperative postoperative effects...
Abstract Objective: To assess whether secretory otitis media may be caused by immune imbalance of Treg/Th17 mediated PI3K/Akt/mTOR signaling, so as to find new therapeutic target. Methods: IL-17, TGF- and IL-6, IL-10 Th17 cytokines were detected in peripheral blood OME patients (PC group) healthy people (NC ELISA. The expression ROR t mRNA Foxp3mRNA PBMC was RT-PCR. rat model established the changes lymphocytes middle ear mucosa spleen signaling HE staining, IHC, WB flow cytometry. Results:...
Objective: To assess whether secretory otitis media may be caused by immune imbalance of Treg/Th17 mediated PI3K/Akt/mTOR signaling, so as to find new therapeutic target. Methods: IL-17, TGF- and IL-6, IL-10 Th17 cytokines were detected in peripheral blood OME patients (PC group) healthy people (NC ELISA. The expression ROR t mRNA Foxp3mRNA PBMC was RT-PCR. rat model established the changes lymphocytes middle ear mucosa spleen signaling HE staining, IHC, WB flow cytometry. Results: (OME)...