A5086610350- Violence, Education, and Gender Studies
- Educational theories and practices
- Cancer-related Molecular Pathways
- Educational Research and Science Teaching
- Knowledge Societies in the 21st Century
- Educational Innovations and Technology
- DNA Repair Mechanisms
- Business, Education, Mathematics Research
- Science Education and Pedagogy
- Cancer, Hypoxia, and Metabolism
- Educational Outcomes and Influences
- Education and Critical Thinking Development
- Educational Strategies and Epistemologies
- Accounting and Financial Management
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Chromatin Dynamics
- Hernia repair and management
- Cerebral Venous Sinus Thrombosis
- Appendicitis Diagnosis and Management
- Social Skills and Education
- Vascular Malformations Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- PARP inhibition in cancer therapy
- Breast Lesions and Carcinomas
Centro Hospitalar de Entre o Douro e Vouga E.P.E.
2024
Pontifical Catholic University of Peru
2017-2023
Hospital da Senhora da Oliveira Guimarães
2022
Karolinska University Hospital
2021
Karolinska Institutet
2021
Janssen (United States)
2014-2017
University Health Network
2008-2016
Princess Margaret Cancer Centre
2016
University of Toronto
2008-2016
Hélio Alonso University
2016
Abstract CD47, a broadly expressed cell surface protein, inhibits phagocytosis via interaction with phagocyte-expressed SIRPα. A variety of hematological malignancies demonstrate elevated CD47 expression, suggesting that may mediate immune escape. We discovered three unique CD47-SIRPα blocking anti-CD47 monoclonal antibodies (mAbs) low nano-molar affinity to human and cynomolgus monkey no hemagglutination platelet aggregation activity. To characterize the anti-cancer activity elicited by...
The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. interaction between these monomer units can be modified by the action small molecules in binding interface their C-terminal heterodimerization (PasB) domains. Taking advantage presence several cysteine residues located allosteric cavity PasB domain, we applied cysteine-based reactomics "hotspot identification" strategy locate...
Understandings of the nature scientific inquiry (NOSI), as opposed to engaging students in learning experiences, are included science education reform documents around world. However, little is known about what have learned NOSI during their pre-college school years. The purpose this large-scale follow-up international project (i.e. 32 countries and regions, spanning six continents including 3917 for high sample) was collect data on exiting NOSI. Additionally, study investigated changes 12th...
Knowledge of scientific inquiry (SI) is considered essential to the development an individual's Scientific Literacy (SL) and therefore, SI included in many international science education reform documents. Two previous large scale studies assessed understandings students entering middle school secondary at end their formal K-12 education. The purpose this project was use VASI-E collect data on what primary level have learned about first few years school. This study adds research bridge...
The Per-Arnt-Sim (PAS) domains of hypoxia-inducible transcription factors (HIF) mediate heterodimer formation between the HIF-α forms that are induced in event cellular hypoxia and constitutive HIF-β variants. Previous efforts toward structural characterization HIF-1α PAS were limited by protein stability. Using homology modeling based on published crystal structure PAS-B domain homologous HIF-2α complex with partner (also known as ARNT), we have identified a variant improved solubility,...
Abstract Tencons are engineered alternative scaffold proteins that combine the affinity and specificity of antibodies with biophysical features smaller molecules hold high promise as biotherapeutic agents. We present crystal structures antigen binding data several anti-Tumor Tencon variants. The variants show a switch FG loop conformation from α-helical at tip to mostly β-strands. This conformational change prompts differential exposure potential residues finger-like shape for region may...
Abstract Centyrins are engineered alternative scaffold proteins that combine the affinity and specificity of antibodies with increased tissue penetration simplified manufacturing. To identify optimal positions for chemical conjugation within Centyrin scaffold, crystal structure an anti-EGFR was solved a library consisting all possible single-cysteine variants constructed assessed expression level in E. coli, efficiency to maleimide derivatives, protein aggregation, thermostability, EGFR...
ResumenEn esta comunicación se mostrará una mirada de escenarios para promover competencias matemáticas: generales, referidas al contenido matemático y ámbito exigencia, en estudiantes del primer ciclo Estudios Generales Letras que incluye carreras las Ciencias Sociales (Antropología, Sociología) Humanas (Literatura, Psicología, Historia, Geografía, Lingüística, Filosofía) universidad peruana, a partir experimentos enseñanza enmarcadas la Educación Matemática Realista (EMR) Freudenthal...