A5028182980- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Birth, Development, and Health
- Child and Adolescent Psychosocial and Emotional Development
- Neuroendocrine regulation and behavior
- Maternal Mental Health During Pregnancy and Postpartum
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Mental Health Treatment and Access
- Mental Health and Psychiatry
- Neural and Behavioral Psychology Studies
- Bipolar Disorder and Treatment
- Neuroscience and Neuropharmacology Research
- Sex and Gender in Healthcare
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Eating Disorders and Behaviors
- Obsessive-Compulsive Spectrum Disorders
- Heart Rate Variability and Autonomic Control
- Fetal and Pediatric Neurological Disorders
- Treatment of Major Depression
- Diet and metabolism studies
- Regulation of Appetite and Obesity
Harvard University
2015-2024
Brigham and Women's Hospital
2014-2024
Massachusetts General Hospital
2015-2024
Individual Differences
2020-2024
Athinoula A. Martinos Center for Biomedical Imaging
2012-2024
Imaging Center
2010-2024
Laureate Institute for Brain Research
2024
McLean Hospital
2016-2024
Mount Sinai Queens
2023
Women's Health Research Institute
2016-2021
The etiology and consistency of findings on normal sexual dimorphisms the adult human brain are unresolved. In this study, we present a comprehensive evaluation cortical subcortical regions, using in vivo magnetic resonance imaging, community sample 48 adults. men women were similar age, education, ethnicity, socioeconomic status, general intelligence handedness. Forty-five regions assessed based T1-weighted three-dimensional images acquired from 1.5 T magnet. Sexual volumes more evident...
Understanding sex differences in stress regulation has important implications for understanding basic physiological the male and female brain their impact on vulnerability to chronic medical disorders associated with response circuitry. In this functional magnetic resonance imaging study, we demonstrated that significant activity circuitry were dependent women's menstrual cycle phase. Twelve healthy Caucasian premenopausal women compared a group of men from same population, based age,...
Diffusion MRI has been successful in identifying the existence of white matter abnormalities schizophrenia vivo. However, role these etiology is not well understood. Accumulating evidence from imaging, histological, genetic, and immunochemical studies support involvement axonal degeneration neuroinflammation--ubiquitous components neurodegenerative disorders--as underlying pathologies abnormalities. Nevertheless, current imaging modalities cannot distinguish neuroinflammation degeneration,...
Relatively few magnetic resonance imaging studies of schizophrenia have investigated the entire cerebral cortex. Most focus on only a areas within lobe or an lobe. To assess expected regional alterations in cortical volumes, we used new method to segment neocortex into 48 topographically defined brain regions. We hypothesized, based previous empirical and theoretical work, that dorsolateral prefrontal paralimbic cortices would be significantly volumetrically reduced patients with compared...
A survey of the literature suggests that women tend to exhibit a more favorable course schizophrenia than men. This seems be true for range outcome measures, such as hospital treatment, psychopathology, and social adaptation. Due methodological limitations, however, empirical evidence gender differences in is not wholly consistent. In 1983, study first-admitted patients with DSM-III diagnoses or schizophreniform disorder (n = 278) from Greater Hannover area Federal Republic Germany followed...
This study tested the hypothesis that schizophrenic women experience a less severe course of illness than men. Ninety patients with DSM-III diagnoses schizophrenia, who were in early stages illness, followed for 10 years respect to rehospitalizations and length time hospital. Multivariate regression techniques used test gender differences across multiple outcomes. The experienced fewer shorter stays did These findings not an artifact diagnosis. results suggest determinants occur during...
Background: Clues to the causes of schizophrenia can be derived from studying first-degree relatives because they are genetically related an ill family member.Abnormalities observed in nonpsychotic indicators possible genetic vulnerability illness, independent psychosis.We tested 4 hypotheses: (1) that hippocampal volume is smaller than controls, particularly left hemisphere; (2) hippocampi will multiplex as compared with simplex relatives, and both controls; (3) volumes verbal declarative...
Previous studies suggest that the impact of early insults predisposing to schizophrenia may have differential consequences by sex. We hypothesized brain regions found be structurally different in normal men and women (sexual dimorphisms) abnormal would show significant sex differences abnormalities, particularly cortex, schizophrenia.Forty outpatients diagnosed as having DSM-III-R were systematically sampled comparable within with 48 comparison subjects on basis age, ethnicity, parental...
Although sex differences have been demonstrated in behavioral paradigms of fear conditioning, the findings inconsistent, and extinction has little studied. The present study investigated influence menstrual cycle phase on recall extinction. Three groups healthy adult participants were studied: women at 2 different phases (early follicular [early cycle] late [midcycle]) men. Participants underwent a 2-day conditioning protocol. paradigm entailed habituation, learning Day 1 renewal 2. Skin...
<h3>Background:</h3> Previous studies have provided evidence of food motivation circuitry dysfunction in individuals with anorexia nervosa. However, methodological limitations present challenges to the development a cohesive neurobiological model Our goal was investigate neural appetite dysregulation across states hunger and satiety active weight-restored phases nervosa using robust methodology advance our understanding potential abnormalities related hedonic nonhedonic state trait....