A5069251147- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Endometrial and Cervical Cancer Treatments
- Head and Neck Cancer Studies
- Advances in Oncology and Radiotherapy
- Radiation Detection and Scintillator Technologies
- Effects of Radiation Exposure
- Radiation Effects and Dosimetry
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Digital Radiography and Breast Imaging
- Ovarian cancer diagnosis and treatment
- Prostate Cancer Treatment and Research
- AI in cancer detection
- Congenital Heart Disease Studies
- Radiopharmaceutical Chemistry and Applications
- Brain Metastases and Treatment
- Colorectal and Anal Carcinomas
Stanford University
2021-2025
Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi
2023-2024
University of Health Science
2023
University of Health Sciences
2023
Sağlık Bilimleri Üniversitesi
2023
Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
2013-2023
Loyola University Chicago
2014-2021
Loyola University Medical Center
2012-2020
Ministry of Health
2015
University of Chicago
2011-2015
To investigate the effects of adaptive radiotherapy on dosimetric, clinical, and toxicity outcomes for patients with head neck cancer undergoing chemoradiotherapy intensity-modulated radiotherapy.Fifty-one advanced underwent definitive original plan optimized to deliver 70.2 Gy. All were resimulated at a median dose 37.8 Gy (range, 27.0-48.6 Gy) due changes in tumor volume and/or patient weight loss (>15% from baseline). Thirty-four replanning their boost planning (21.6 Gy). The dosimetric...
Abstract Background Biology‐guided radiotherapy (BgRT) is a novel delivery technique that utilizes the tumor itself to guide dynamic of treatment dose tumor. The RefleXion X1 system first developed deliver SCINTIX® BgRT. characterized by its split arc design, employing two 90‐degree positron emission tomography (PET) arcs therapeutic radiation beams in real time, currently cleared FDA treat bone and lung tumors. Purpose This study aims comprehensively evaluate capabilities SCINTIX evaluating...
Purpose: Volumetric modulated arc therapy (VMAT) treatment planning studies have been reported to provide good target coverage and organs at risk (OARs) sparing in total marrow irradiation (TMI). A comprehensive dosimetric study simulating the clinical situation as close possible is a norm radiotherapy before technique can be used treat patient. Without such study, it would difficult make reliable safe transition especially with complicated VMAT-TMI. To this end, feasibility of VMAT-TMI...
Purpose: To evaluate the efficacy of dual‐energy (DE) vs single‐energy (SE) fluoroscopic imaging lung tumors using a markerless template‐based tracking algorithm. Methods: Ten representative patient breathing patterns were programmed into Quasar™ motion phantom. The phantom was modified by affixing pork ribs to surface, and cedar insert with small spherical volume used simulate tumor, respectively. Sequential 60 kVp (6 mA) 120 (1.5 sequences acquired. Frame‐by‐frame weighted logarithmic...
We describe a multicenter cross validation of ultra-high dose rate (UHDR) (>= 40 Gy/s) irradiation in order to bring dosimetric consensus absorbed water. UHDR refers rates over 100-1000 times those conventional clinical beams. irradiations have been topic intense investigation as they reported induce the FLASH effect which normal tissues exhibit reduced toxicity relative rates. The need establish optimal beam parameters capable achieving vivo has become paramount. It is therefore necessary...
Abstract Purpose Ultra-high dose-rate radiotherapy (FLASH) has been shown to mitigate normal tissue toxicities associated with conventional dose rate (CONV) without compromising tumor killing in preclinical models. A prominent challenge radiation research, including FLASH, is validating both the physical dosimetry and biological effects across multiple institutions. Methods We previously demonstrated dosimetric reproducibility of two different electron FLASH devices at separate institutions...
Abstract Background FLASH radiation therapy (RT) offers a promising avenue for the broadening of therapeutic index. However, to leverage full potential in clinical setting, an improved understanding biological principles involved is critical. This requires availability specialized equipment optimized delivery conventional (CONV) and ultra‐high dose rate (UHDR) irradiation preclinical studies. One method conduct such radiobiological research involves adapting linear accelerator configured...
To develop decision trees predicting for tumor volume reduction in patients with head and neck (H&N) cancer using pretreatment clinical pathological parameters.Forty-eight treated definitive concurrent chemoradiotherapy squamous cell carcinoma of the nasopharynx, oropharynx, oral cavity, or hypopharynx were retrospectively analyzed. These rescanned at a median dose 37.8 Gy replanned to account anatomical changes. The percentages gross (GTV) change from initial rescan computed tomography (CT;...
We evaluated the performance of organ contour propagation from a planning computed tomography to cone-beam with deformable image registration by comparing contours manual contouring.Sixteen patients were retrospectively identified based on showing considerable physical change throughout course treatment. Multiple organs in 3 regions (head and neck, prostate, pancreas) evaluated. A end treatment was registered using rigid registration, followed registration. The copied sets modified 2...
Blood products, including apheresis platelets and plasma, are essential for medical use but pose risks of bacterial contamination viral transmission. Platelets prone to growth due their storage conditions, while plasma requires extensive screening. This study explores rapid irradiation as an innovative pathogen reduction method. A clinical linear accelerator was configured deliver ultra-high dose rate (6 kGy/min) platelet components. spiked with Escherichia coli (E. coli; 10⁵ colony-forming...
Introduction: Radiotherapy is effective for breast cancer treatment but often causes undesirable side effects that impair quality of life. Ultra-high dose rate radiotherapy (FLASH) has shown reduced normal tissue toxicity while achieving comparable tumor growth delay compared to conventional (CONV). This study evaluated whether FLASH could achieve similar control as CONV with eradication the primary endpoint, in an orthotopic model. Methods: Non-metastatic, tumors were generated left fourth...
Abstract Objective: The first clinical biology-guided radiation therapy system, RefleXion X1, was commissioned for use at our institution. This study evaluates the X1 treatment planning feasibility of complex craniospinal targets pediatric medulloblastoma patients and compares plan quality to multi-isocenter linac-based Volumetric Modulated Arc Therapy (VMAT) plans. Methods: Five treated with VMAT irradiation (CSI) were selected this retrospective study. All target volumes (PTVs) had a...
Objectives: Angiotensin-converting enzyme inhibitors (ACEi) have demonstrated decreased rates of radiation-induced lung injury in animal models and clinical reports pneumonitis the setting conventionally fractionated radiation to lung. We tested role ACEi diminishing symptomatic (grade ≥2) stereotactic body therapy (SBRT). Methods: analyzed patients treated with thoracic SBRT 48 60 Gy 4 5 fractions from 2006 2014. reviewed pretreatment posttreatment medication profiles document use ACEi,...
To evaluate markerless tumor tracking (MTT) using fast-kV switching dual-energy (DE) fluoroscopy on a bench top system.Fast-kV DE was implemented which includes turntable stand, flat panel detector, and x-ray tube. The customized generator firmware enables consecutive pulses that alternate between programmed high low energies (e.g., 60 120 kVp) with maximum frame rate of 15 Hz. In-house software to perform weighted subtraction images create an image sequence removes bone enhances soft...
The first clinical biology-guided radiation therapy (BgRT) system-RefleXion
The RefleXion X1 is a novel radiotherapy machine designed for image-guided (IGRT) and biology-guided (BgRT). Its treatment planning system (TPS) generates IMRT SBRT plans 6MV-FFF beam delivered axially via 50 firing positions with the couch advancing every 2.1 mm. purpose of this work to report TPS commissioning results first clinical installation RefleXion™ X1.
This study reports the beam commissioning results for first clinical RefleXion Linac.The X1 produces a 6 MV photon and maximum field size is 40 × 2 cm2 at source-to-axis distance of 85 cm. Treatment fields are collimated by binary multileaf collimator (MLC) system with 64 leaves width 0.625 cm y-jaw pairs to provide either 1 or opening. The mechanical alignment radiation source, y-jaw, MLC were checked film ion chambers. parameters characterized using diode detector in compact water tank....
The aim of this study was to apply the Six Sigma methodology and failure mode effect analysis (FMEA) mitigate errors in intensity modulated radiation therapy (IMRT) stereotactic body (SBRT) treatment planning with first clinical installation RefleXion X1.The approach consisted 5 phases: define, measure, analyze, improve, control. analyze phases process mapping an FMEA IMRT SBRT on X1. multidisciplinary team outlined workflow identified ranked modes associated plan check items using American...
Purpose Although stereotactic body radiation therapy (SBRT) is an attractive noninvasive approach for liver irradiation, it presents specific challenges associated with respiration‐induced motion, daily tumor localization due to deformation, and poor visualization of target respect adjacent normal in computed tomography (CT). We aim identify potential hazards develop a set mitigation strategies improve the safety our SBRT program, using failure mode effect analysis (FMEA). Materials methods...