Introduction: Exosomes play significant roles in transferring cargo materials like proteins, RNAs (including miRNAs), and DNA. However, the role of serum exosome shuttled miRNAs head neck cancer (HNC) remains unclear. This study assessed diagnostic prognostic significance exosomal miR-17, miR-20a, TGFBR2 HNC patients. Methods: were isolated, from 400 confirmed patients healthy controls, characterized by NTA, TEM, Immunolabelling, ELISA. Quantitative PCR was used to check expressions...

The depletion of natural sand resources occurs due to excessive consumption aggregate for concrete production. Continuous extraction from riverbeds permanently depletes fine resources. At the same time, a major ecological challenge is disposal agricultural waste ash biomass burning. In this study, an environmental friendly solution proposed investigate incorporation wheat straw (WSA) by replacing 0, 5, 10, 15, and 20% in concrete. Characterization results WSA revealed that it was...

Exosomes are small-diameter endosomal vesicles secreted in all biological fluids and play biological/pathological roles the cell. These pathological played by exosome's cargo molecules through inter-cellular communication. Exosomal contain proteins miRNAs. miRNAs small non-coding RNA fragments involved reduction of final protein output destabilizing or suppressing translation target messenger (mRNA). This deregulation due to ultimately accelerates process disease pathogenesis. The role...

Aim: The current study was designed to evaluate the diagnostic significance of exosomal miRNAs miR-19a and miR-19b PTEN gene in brain tumor patients versus controls. Methods: Exosomes were extracted from serum samples 400 healthy exosomes characterized by scanning electron microscopy, dynamic light scattering ELISA. Quantitative PCR used analyze selected exosome expression levels. Results: Analysis showed significant deregulated (p < 0.0001), 0.0001) 0.001) Spearman correlation a among gene....

The present study aimed to figure out the potential role of exosomal microRNAs, and their targeted genes in HNC detection/diagnosis.

Purpose The purpose of this paper is to reduce the gap in understanding complexity barriers, their modifiers and how these barriers result malpractices missed good practices post-earthquake reconstruction contexts. This provides insights often asked question: why lessons learnt from one earthquake event are not actually many mistakes around housing repeated? Design/methodology/approach based on review literature top deadliest earthquakes developing countries two case studies 2005 Kashmir...

Abstact&#x0D; Purpose of the study was to determine problematics empowering poor. Research uses literature review method, collecting data using a literacy analysis related empowerment process and observing programs. Results explained that problem poor people occurred in time efficiency, understanding The factors causing these problems are: a). lack synchronization between central practitioner planning. b). not yet accordance with application method midst diversity. c). use old paradigm...

AbstrakPenelitian ini bertujuan untuk mengetahui implemetasi Program Penyediaan Air Minum dan Sanitasi Berbasis Masyarakat (PAMSIMAS) pada masyarakat Desa Padang Mutung. Penelitian menggunakan metode kualitatif, pengumpulan data observasi, wawancara peninjauan dokumen. Hasil penelitian menjelaskan PAMSIMAS melakukan sosialisasi sanitasi lingkungan yaitu, penyampaian materi pemahaman kondisi limgkungan Mutung kemudian aksi praktis bersih-bersih perkarangan rumah hingga DAS. Ke dua, kegiatan...

This research study focuses on the assessment of solid waste management in Peshawar, one Pakistan's largest cities, with a population approximately 1.97 million people. The city faces significant challenges managing its waste, resulting inadequate collection and disposal services. examines current state including generation, methods, storage practices, recovery recyclable materials. socio-economic classes are also evaluated based residential locations family incomes. findings highlight need...

Previous studies on brain tumors have been performed the nuclear genome, but limited reported mitochondrial genome. The sirtuin (SIRT3/SIRT4/SIRT5) has mutated in different cancers. Limited tumors. Isocitrate dehydrogenase (IDH) is an important marker, and polymorphism IDH gene to differentiate tumor subtypes.

Vigna radiata (mung bean) is a well-known agricultural crop with high nutritional value and adaptability. In volatile climates, drought stress poses threat to its production. Moringa Leaf Extract (MLE) natural remedy that includes bioactive ingredients eco-friendly organic fertilizer. order improve plant growth, productivity, water usage effectiveness, nutrient availability, MLEs are essential for controlling stress. This mixture strengthens resilience works well habitats lack water. The...

Abstract:This research aims to explore and analyze the socio-economic dynamics of street vendors at Putri Kaca Mayang tourist attraction. This uses an economic sociology approach understand social interactions factors that influence vendors. Qualitative methods were used with in-depth interviews, observation, document analysis as data collection techniques. The results this provide a deeper understanding Business location, government regulations, consumer behavior are main things their...

Abstrak Penelitian ini bertujuan untuk mengidentifikasi faktor lingkungan dan konteks kerentanan di masyarakat lokal, mengenali masalah sosial gambaran kondisi sosial-ekonomi serta pelaku kelompok kunci yang berpengaruh Desa Tarai Bangun, Kecamatan Tambang, Kabupaten Kampar, Provinsi Riau. Desain penelitian dilakukan secara kualitatif deskriptif dengan pendekatan Rapid Rural Appraisal (RRA) sampel perwakilan, wawancara mendalam observasi. Dari hasil disimpulkan pihak-pihak menjadi proses...

Globally, approximately one-third of greenhouse gas (GHG) emissions are attributed to the energy sector. The global efforts reduce by 45 percent 2030 in pursuit net-zero emission targets depend on timely completion renewable projects. Among numerous internal and external factors that influence success projects, performance workforce response changing project dynamics is a key yet little-explored factor. As such, complexities uncertainties brought about COVID-19 pandemic only enhanced...

The loss of fresh fruits after harvesting is not new since it has constantly been a challenge for humankind. growing population in developing countries, where food shortages exist, require serious security measures to address hunger and malnutrition. Present research focused on the development, fabrication testing mango pulp extractor assist small-scale fruit farmers countryside with view minimizing spoilage. unit, whose major material was grade stainless steel (SS-304), consists components...