A5054159846- Lipid Membrane Structure and Behavior
- Force Microscopy Techniques and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Materials and Mechanics
- Mechanical and Optical Resonators
- Nanopore and Nanochannel Transport Studies
- Microfluidic and Capillary Electrophoresis Applications
- Enzyme Structure and Function
- Chemical Analysis and Environmental Impact
- Surfactants and Colloidal Systems
- Pickering emulsions and particle stabilization
- Calcium Carbonate Crystallization and Inhibition
- Modular Robots and Swarm Intelligence
- Electron Spin Resonance Studies
- thermodynamics and calorimetric analyses
- RNA Interference and Gene Delivery
- Supramolecular Self-Assembly in Materials
- Diatoms and Algae Research
- Electrowetting and Microfluidic Technologies
University of Massachusetts Amherst
2021-2024
High Throughput Biology (United States)
2024
University of Massachusetts Boston
2023
The morphologies of two-dimensional (2D) crystals, nucleated, grown, and integrated within 2D elastic fluids, for instance in giant vesicle membranes, are dictated by an interplay mechanics, permeability, thermal contraction. Mitigation solid strain drives the formation crystals with vanishing Gaussian curvature (i.e., developable domain shapes) and, correspondingly, enhanced surrounding fluid. However, upon cooling to grow large vesicles sustain greater inflation tension because their small...
Biological or biomimetic membranes are examples within the larger material class of flexible ultrathin lamellae and contoured fluid sheets that require work energy to impose bending deformations. Bending elasticity also dictates interactions assembly integrated phases molecular clusters lamellae, for instance enabling critical cell functions in biomembranes. More broadly, lamella other thin fluids integrate dispersed objects, inclusions, behave as 2D colloidal suspensions governed by elastic...
High Throughput Screening is crucial in pharmaceutical companies for efficient testing drug discovery and development. Our Vaccines Analytical Research Development Department (V-AR&D) extensively uses Robotic Liquid Handlers their Analytics (HTA) group assay development sample screening. However, these instruments are expensive require extensive training. Opentrons' OT-2 liquid handler offers a more affordable option (< $10,000) with Python programming language open-source flexibility,...
Mechanical stimuli direct reversible intramembrane positioning of flat rigid microdomains on scales up to tens micrometers.
Suspensions of colloidal microplates in contoured 2D elastic fluids sheets are dominated by the bending mechanics and shear rigidity plates contrasting in-plane flow fluid. Using phase separated phospholipid membranes individual giant unilamellar vesicles as models suspensions, where solid domains act colloids a fluid membrane, we explore elasticity-driven assembly. The plate-shaped varied between 1-10 {\mu}m diameter, with 4-100 per vesicle depending on size, contributing area 17 plus minus...
The morphologies of two-dimensional (2D) crystals, nucleated, grown, and integrated within 2D elastic fluids, for instance in giant vesicle membranes, are dictated by an interplay mechanics, permeability, thermal contraction. Mitigation solid strain drives formation crystals with developable shapes (e.g. planar or cylindrical) that expel Gaussian curvature into the fluid. However, upon cooling to grow large vesicles sustain greater inflation tension because their small area volume ratio...