A5046711229- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Heme Oxygenase-1 and Carbon Monoxide
- Ion channel regulation and function
University of Arizona
2021
Edema is an important target for clinical intervention after traumatic brain injury (TBI). We used in vivo cellular resolution imaging and electrophysiological recording to examine the ionic mechanisms underlying neuronal edema their effects on network excitability controlled cortical impact (CCI) mice. Unexpectedly, we found that 48 hours CCI was associated with reduced excitability, concurrent increase expression ratio of cation-chloride cotransporters (CCCs) NKCC1 KCC2. Treatment CCC...
Neuroprotective strategies for stroke remain inadequate. Nanoliposomes comprised of phosphatidylcholine, cholesterol, and monosialogangliosides (nanoliposomes) induced an antioxidant protective response in endothelial cells exposed to amyloid insults. We tested the hypotheses that nanoliposomes will preserve human neuroblastoma (SH-SY5Y) brain microvascular viability following oxygen-glucose deprivation (OGD)-reoxygenation reduce injury mice middle cerebral artery occlusion.
Neuroprotective strategies for stroke remain inadequate. Nanoliposomes comprised of phos-phatidylcholine, cholesterol and monosialogangliosides (NL) induced an antioxidant protective response in endothelial cells exposed to amyloid insults. We tested the hypotheses that NL will preserve SH-SY5Y neuroblastoma cell viability following hypoxic injury reduce mice middle cerebral artery occlusion (MCAO). Neuroblastoma were 20-hour physoxic (5% oxygen) or (1% condition without with (100 300...