A5073904629- Neuroendocrine Tumor Research Advances
- Adipokines, Inflammation, and Metabolic Diseases
- Parathyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Gout, Hyperuricemia, Uric Acid
- Streptococcal Infections and Treatments
- Neuroblastoma Research and Treatments
- Immune Response and Inflammation
- Magnesium in Health and Disease
- Renal Diseases and Glomerulopathies
- Kruppel-like factors research
- Bone health and treatments
- Gestational Diabetes Research and Management
- Organ Donation and Transplantation
- Rabies epidemiology and control
- Pressure Ulcer Prevention and Management
- Neurological and metabolic disorders
- Adrenal Hormones and Disorders
- Peroxisome Proliferator-Activated Receptors
- Cancer, Stress, Anesthesia, and Immune Response
- Congenital Anomalies and Fetal Surgery
- Infections and bacterial resistance
Norfolk and Norwich University Hospital
2010-2023
University of East Anglia
2023
Norfolk and Norwich University Hospitals NHS Foundation Trust
2011-2019
University of Oxford
2002-2012
Oxford Centre for Diabetes, Endocrinology and Metabolism
2012
Kennedy Center
2009-2010
Institute of Rheumatology
2009-2010
Imperial College London
2007-2009
Nuffield Orthopaedic Centre
2002-2003
Hammersmith Hospital
1999-2002
The calcium-sensing receptor (CaSR) is a G-protein-coupled that has an extracellular bilobed venus flytrap domain (VFTD) predicted to contain five calcium (Ca2+)-binding sites. To elucidate the structure–function relationships of VFTD, we investigated 294 unrelated probands with familial hypocalciuric hypercalcaemia (FHH), neonatal severe primary hyperparathyroidism (NSHPT) or autosomal dominant hypocalcaemic hypercalciuria (ADHH) for CaSR mutations and performed in vitro functional...
CACCC-boxes are recognised by transcription factors of the Sp/Krüppel-like Factor (Sp1/KLF) family. Here we describe one member this family, KLF8/ZNF741/BKLF3 (KLF8). KLF8 contains a characteristic C-terminal DNA-binding domain comprised three Krüppel-like zinc fingers, but also has limited homology to another family member, KLF3/Basic (KLF3/BKLF), in its N-terminus. Most significantly, it shares with KLF3/BKLF Pro-Val-Asp-Leu-Ser/Thr motif. In motif mediates contact co-repressor protein...
Gout, which is commonly associated with hyperuricemia, affects 0.2% of the population. Hyperuricemia has a heterogeneous etiology that may be due to either over production and/or reduced renal clearance, urate. In order identify mechanisms underlying excretion urate, we undertook positional cloning studies familial juvenile hyperuricaemic nephropathy (FJHN), an autosomal dominant disorder characterized by hyperuricaemia, low fractional and chronic failure interstitial fibrosis. The FJHN...
The interaction of myoglobin with H2O2 leads via a two-electron oxidation process to the formation ferryl myoglobin. Metmyoglobin is more readily activated than oxymyoglobin states, which are capable inducing peroxidative damage membranes. E.p.r. and optical spectroscopic studies show that thiol-containing compounds N-(2-mercaptopropionyl) glycine N-acetylcysteine trihydroxamate desferrioxamine attenuate these processes by reducing species metmyoglobin, thiyl radicals nitroxide radical...
Summary background Familial isolated hyperparathyroidism (FIHP) is an autosomal dominant disorder characterized by uniglandular or multiglandular parathyroid tumours that occur in the absence of other endocrine tumours. The may represent either early stage multiple neoplasia type 1 (MEN1), allelic variant MEN1, a distinct entity involving another locus. We have explored these possibilities seven families whom primary occurred as sole endocrinopathy. methods Seven FIHP were ascertained and...
Summary Background Preoperative localisation is important for successful surgical treatment of gastrinomas. However, a satisfactory method that achieves this has not been defined, and at present somatostatin receptor scintigraphy selective intra‐arterial stimulation testing with secretin have the greatest sensitivities. As now difficult to obtain, we decided explore use calcium gluconate as secretagogue. High extracellular concentrations cause degranulation neuroendocrine cells subsequent...
MEN1 is an autosomal dominant disorder characterized by parathyroid, pituitary, and pancreatic tumors. The gene located on chromosome 11q13 encodes a 610-amino acid protein. mutations are of diverse types scattered throughout the coding region, such that almost every family will have its individual mutation. To further characterize we ascertained 34 unrelated probands undertook DNA sequence analysis. This identified 17 different in 24 (2 nonsense, 2 missense, in-frame deletions, 5 frameshift...
Obesity is regarded as a pro-inflammatory state. It associated with low circulating levels of the adipokine, adiponectin, which considered to be an anti-inflammatory. However, adiponectin knockout mice do not consistently demonstrate phenotypes, suggesting more complexity in vivo immunomodulatory effects than originally anticipated. Moreover, exerts some experimental systems. This contradiction has been resolved by hypothesizing that induces tolerance inflammatory stimuli, notably Toll-like...
Summary The poor prognosis of obesity is now known to involve a proinflammatory state associated with elevated circulating levels cytokines and macrophage infiltration adipose tissue. In particular, Toll-like receptor (TLR)-4-driven inflammation has been implicated recently in the development diabetes. Adipocytes are recognized as an important source cytokine chemokine production, including interleukin (IL)-6 monocyte chemotractant protein (MCP)-1, this appears be key step obesity-associated...
Toll-like receptors (TLRs) are central to innate immunity and yet their expression is widespread not restricted professional inflammatory cells. TLRs have been reported on adipocytes implicated in obesity-associated pathologies such as diabetes. Why found clear although one hypothesis that they may coordinate energy utilization for the intensive process of an immune response. We explored TLR signalling primary human vitro differentiated investigated specific adapter molecules involved. Only...
This study describes a novel approach to generate conditionally immortalized preadipocyte cell lines from white adipose tissue (IMWAT) that can be induced differentiate into adipocytes even after expansion in culture. Such express markers of fat such as peroxisome proliferator-activated receptor γ and aP2 but not brown markers, have an intact insulin signaling pathway, proinflammatory cytokines. They readily transduced with adenoviral vectors, allowing them used investigate the consequences...
Abstract Aims To develop an antibiotic foot formulary for the empirical treatment of diabetes‐related infections presenting to our service. Subsequently, asses costs associated with introduction protocol, in particular assess effect on admissions avoidance and any cost savings achieved. Methods We reviewed several existing protocols. analysed data related admission rates prior after protocol. Results rationalized protocol adapted Infectious Disease Society America guideline by introducing a...
A 25 year old man presented with anuria and bilateral leg pain two days after an alcoholic binge. He subsequently developed rhabdomyolysis causing acute renal failure, compartment syndrome of both lower legs. This required urgent dialysis fasciotomy respectively within six hours admission. remained dependent for three weeks only four months was he able to weight bear on Alcohol is a leading cause rhabdomyolysis. Early recognition prompt treatment essential prevent serious complications.
A 43-year-old man with a 28-year history of type 1 diabetes presented to our foot clinic in February 2008 fractured left second proximal phalanx due trauma. His control was poor, an HbA1c 79 mmol/mol (9.4%) [reference range <42 mmol/mol (<6.0%)] at presentation. He known have diabetic peripheral neuropathy, and had previously undergone bilateral pan retinal photocoagulation for proliferative retinopathy. medications were insulin aspart, glargine, ramipril, simvastatin, esomeprazole,...
To investigate factors influencing diagnostic discordance for non-diabetic hyperglycaemia and Type 2 diabetes.Some 10 000 adults at increased risk of diabetes were screened with HbA1c fasting plasma glucose (FPG). The 2208 participants initial ≥ 42 mmol/mol (≥ 6.0%) or FPG 6.1 mmol/l retested after a median 40 days. We compared the first second results, consequent diagnoses diabetes, investigated predictors discordant diagnoses.Of 1463 394 on testing, 28.4% 21.1% respectively had repeated...
A woman with Type I diabetes presented at 6<sup>+0</sup>/40 a history of severe retinopathy, hypertension and nephropathy. previous combined renal pancreatic transplant had failed necessitating haemodialysis five times week. She miscarried DCDA twin pregnancy 21 weeks the year. At 25<sup>+6</sup>/40 fetal ultrasound indicated growth restriction, absent umbilical artery diastolic flow. Dexamethasone was administered. Fetal wellbeing monitored biophysical profiling until 27<sup>+1</sup>/40...
Abstract Robotic reconstructions of large diaphragmatic defects with mesh are rare in the literature. We present a case complicated defect, an adult trisomy 21, which was successfully repaired robotically double reinforcement. The meshes were sutured together via separate suture middle to avoid fluid accumulation between them. patient recovered quickly and uneventfully. On follow-up, he reported no pain, his performance score improved dramatically. this reconstruction specific patient, who...
Conference Abstract| July 01 2002 Phenocopies in Multiple Endocrine Neoplasia Type 1 (Men1) Present Diagnostic Challenges J O Turner; Turner 1Molecular Endocrinology Group, Nuffield Department of Medicine, University Oxford, OX3 9DU. Search for other works by this author on: This Site PubMed Google Scholar M Stacey; Stacey A Pannett; Pannett R V Thakker Clin Sci (Lond) (2002) 103 (s47): 20P. https://doi.org/10.1042/cs103020Pb Views Icon Article contents Figures & tables Video Audio...
Conference Abstract| July 01 2002 Mapping of Familial Juvenile Hyperuricaemic Nephropathy on Chromosome 16P12 in Six Families J O Turner; Turner 1Molecular Endocrinology Group, Nuffield Dept Medicine, University Oxford, Oxford OX3 9DU Search for other works by this author on: This Site PubMed Google Scholar M Stacey; Stacey B Harding; Harding A Nesbit; Nesbit P Kotanko; Kotanko 2 Internal Krankenhaus der Barmherzigen Bruder, Graz, Austria K Lhotta; Lhotta 3 Clinical Nephrology, Innsbruck...