A5033459267- Herpesvirus Infections and Treatments
- Organoselenium and organotellurium chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Microbial infections and disease research
- Sulfur-Based Synthesis Techniques
- Glycosylation and Glycoproteins Research
- Animal Virus Infections Studies
- Diphtheria, Corynebacterium, and Tetanus
- Organic and Inorganic Chemical Reactions
- Viral gastroenteritis research and epidemiology
- Synthesis and characterization of novel inorganic/organometallic compounds
- Radical Photochemical Reactions
- Toxin Mechanisms and Immunotoxins
- Catalytic Alkyne Reactions
- Crystallography and molecular interactions
- Photochemistry and Electron Transfer Studies
- Virus-based gene therapy research
- Neuroscience and Neuropharmacology Research
- Hepatitis B Virus Studies
- Synthesis of heterocyclic compounds
- Organic and Molecular Conductors Research
- Molecular Junctions and Nanostructures
- Pharmacological Receptor Mechanisms and Effects
- Toxoplasma gondii Research Studies
Prism Biolab Corporation (Japan)
2021-2022
Takeda (Japan)
2013-2015
Asahi Kasei (Germany)
2006
Gifu Pharmaceutical University
1999-2004
Kindai University
2004
Life Science Institute
2004
University of Illinois Urbana-Champaign
2002
Tokyo University of Agriculture and Technology
1987-1997
Gifu University
1997
Hokkaido University
1978-1987
Antibody (IgG) responses to salivary gland homogenate and a recombinant protein from the sand fly Lutzomyia longipalpis were investigated using sera children living in an endemic area of visceral leishmaniasis Brazil. We classified into four groups according their Leishmania antigen: (Group I) positive serology delayed type hypersensitivity (DTH), II) negative DTH, III) IV) DTH. A highly significant correlation was found between anti-salivary IgG levels DTH responses. An L. used as antigen...
The C2-hydroxyglycosylation reaction employing the reagent combination of a diaryl sulfoxide and triflic anhydride offers novel method for glycal assembly whereby hydroxyl functionality is stereoselectively installed at C2-position donor with concomitant glycosylation nucleophilic acceptor. Mechanistic investigations into this revealed process sulfonium-mediated oxidation enol ethers in which oxygen atom transferred to glycal. 18O-labeling studies that S-to-C2 oxygen-transfer involves...
Two strains of corynebacteria were isolated from cows that showed signs cystitis and pyelonephritis. According to the results numerical-analysis deoxyribonucleic acid homology studies, these differed known species Corynebacterium parasitic on or pathogenic humans and/or other animals. These are regarded as belonging two new species, for which names C. pilosum cystitidis proposed. The type 46 Hara (= ATCC 29592) 42 Fukuya 29593), respectively.
Diazomethane add to the enyne sulfones 1, 3, 4, 6–11 regio- and stereo-selectively give 4-alkynyl-5-phenylsulfonyl-4,5-dihydro-3H-pyrazoles 12–15 17–19, which are converted by MeLi into 4-alkynyl-1H-pyrazoles 24, 25, 16, 26, 28, 30 in good yields. 4,5-Bis(alkynyl)-1H-pyrazoles 34, 37 also obtained same procedure.
Abstract Fast reactions of diethyl fumarate anion radical (DEF−) and fluorenone (Fl−) with various organic halides (RX) in hexamethylphosphoric triamide have been studied by means ns pulse radiolysis at room temperature. Reactions acetophenone were also for comparison. It was found that the reaction rate Fl− subject to steric resonance effects R groups RX accord classical concept SN2 reactions: constant reduced 2 orders magnitude effect when changed from ethyl bulky isopropyl or t-butyl, it...
In our last paper it had been implied that the presence of Pt on cathode was more essential for membrane degradation. this both effluent analysis and X-ray CT study have done further understanding These studies support is Second purpose to report influence electrocatalyst, GDL types membranes durability at open circuit voltage, i.e. OCV. It confirmed much less degraded OCV test when using Asahi Kasei Advanced Membrane or Pt:Co alloy as electrocatalyst. results imply problem degradation...
The protein portion of endotoxin (OEP), or common antigen Pseudomonas aeruginosa prepared from strain N10 P aeruginosa, was examined as a possible vaccine against this organism in mink. Mink were given OEP and challenge exposed by instillation with the inoculum into nostril. They survived after exposure 4 median lethal (LD50) doses NC-5 (protease negative, elastase negative) 160 LD50 5 positive, positive). Strain belonged to TYPE AND type 8 (according serotyping method Homma). N10, source...
Selenabenzene is one of the heterobenzenes in which a selenium atom has replaced carbon benzene. Selenabenzenes and their benzo-analogs stabilized by an electron-withdrawing group were synthesized order to study structures, properties, reactivities. Cyano-substituted 1- 2-selenanaphthalenes isolated as orange crystals, while selenabenzenes with too unstable be at room temperature. bearing two stabilizing substituents recently prepared. The structure 2,6-dibenzoyl-1-methylselenabenzene...
Protein-protein interactions (PPIs) are fundamentally important and challenging drug targets. Peptidomimetic molecules of various types have been developed to modulate PPIs. A particularly promising discovery strategy, structural peptidomimetics, was designed based on special mimicking side-chain Cα-Cβ bonds. It is simple versatile. Nevertheless, no quantitative method has established evaluate its similarity a target peptide motif. We two methods that enable visual, comprehensive, analysis...
Bovine herpesvirus 1 (BHV-1) glycoprotein gill functions both as a major virus attachment protein and haemagglutinating protein. Here we constructed recombinant baculovirus incorporating the BHV-1 coding sequence to characterize expression, function immunogenicity of in insect cells. The had an Mr 72K seemed form homodimers. was expressed on surface cells rosette formation assay demonstrated haemadsorbing activity glycoprotein. Antigenic authenticity confirmed by panel monoclonal antibodies...
Selenabenzenes 12a–c with two electron-withdrawing groups (EWGs) at the 2- and 6-positions were synthesized from dihalides 1a, 1b 1c′via seven steps isolated as stable compounds room temperature. According to X-ray structural analysis of dibenzoyl derivative 12c, six-membered ring containing a selenium atom is almost planar structure tetrahedral four sp3 hybridized orbitals.
Selenabenzenes with two electron-withdrawing groups at 2,6-positions 9a–c were isolated and stable room temperature underwent the thermal rearrangement giving 2- 4-methylselenines 13 14 oxygenation reaction dienone 15 selenin-4-one 16.
Currently, various pharmaceutical modalities are being developed rapidly. Targeting protein-protein interactions (PPIs) is an important objective in such development. Cyclic peptides, because they have good specificity and activity, been attracting much attention as alternative to antibody drugs. However, cyclic peptides involve some difficulties, oral availability cell permeability. Therefore, while small-molecule drugs still present many benefits, the screening of functional compounds...
We examined the brains, spleens and/or lymph nodes of 197 mainly suffolk sheep collected from Hokkaido, and Tohoku, Kanto Chubu districts to detect PrPSc thus estimate scrapie contamination in Japan. Sixteen Hokkaido 2 other that were introduced positive for PrPSc. By comparison frequencies restriction fragment length polymorphism (RFLP) types these 18 with 128 healthy sheep, we confirmed association specific RFLP PrP gene natural scrapie. The frequency type I was significantly higher than...
Abstract not Available.