A5048102530- Pesticide and Herbicide Environmental Studies
- Genetically Modified Organisms Research
- Weed Control and Herbicide Applications
- Pesticide Exposure and Toxicity
- Dietary Effects on Health
- Effects and risks of endocrine disrupting chemicals
- Diet and metabolism studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Gut microbiota and health
- Insect and Pesticide Research
- Carcinogens and Genotoxicity Assessment
- Insect Resistance and Genetics
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Nutritional Studies and Diet
- Agricultural safety and regulations
- Agriculture Sustainability and Environmental Impact
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Neurological Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- Folate and B Vitamins Research
- Toxic Organic Pollutants Impact
- Plant and animal studies
King's College London
2016-2025
Guy's Hospital
2016-2025
Buchinger Wilhelmi
2022-2025
Cell Therapy Catapult
2015-2024
Cell and Gene Therapy Catapult
2017-2023
University of London
2019
Universidad de Londres
2019
Université de Caen Normandie
2009-2016
Centre National de la Recherche Scientifique
2009-2014
Laboratoire de Biochimie
2009
The broad-spectrum herbicide glyphosate (common trade name "Roundup") was first sold to farmers in 1974. Since the late 1970s, volume of glyphosate-based herbicides (GBHs) applied has increased approximately 100-fold. Further increases are likely due more and higher rates application response widespread emergence glyphosate-resistant weeds new, pre-harvest, dessicant use patterns. GBHs were developed replace or reduce reliance on causing well-documented problems associated with drift crop...
The health effects of a Roundup-tolerant genetically modified maize (from 11% in the diet), cultivated with or without Roundup, and Roundup alone 0.1 ppb water), were studied 2 years rats. In females, all treated groups died 2-3 times more than controls, rapidly. This difference was visible 3 male fed GMOs. All results hormone sex dependent, pathological profiles comparable. Females developed large mammary tumors almost always often before pituitary second most disabled organ; hormonal...
Pesticides are used throughout the world as mixtures called formulations. They contain adjuvants, which often kept confidential and inerts by manufacturing companies, plus a declared active principle, is usually tested alone. We toxicity of 9 pesticides, comparing principles their formulations, on three human cell lines (HepG2, HEK293, JEG3). Glyphosate, isoproturon, fluroxypyr, pirimicarb, imidacloprid, acetamiprid, tebuconazole, epoxiconazole, prochloraz constitute, respectively, 3 major...
The health effects of a Roundup-tolerant NK603 genetically modified (GM) maize (from 11% in the diet), cultivated with or without Roundup application and alone 0.1 ppb full pesticide containing glyphosate adjuvants) drinking water, were evaluated for 2 years rats. This study constitutes follow-up investigation 90-day feeding conducted by Monsanto order to obtain commercial release this GMO, employing same rat strain analyzing biochemical parameters on number animals per group as our...
Pesticide formulations contain declared active ingredients and co-formulants presented as inert confidential compounds. We tested the endocrine disruption of in six glyphosate-based herbicides (GBH), most used pesticides worldwide. All were comparably cytotoxic well below agricultural dilution 1% (18–2000 times for co-formulants, 8–141 formulations), not ingredient glyphosate (G) alone. The endocrine-disrupting effects all these compounds measured on aromatase activity, a key enzyme balance...
Abstract The impairment of liver function by low environmentally relevant doses glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown that rats administered for 2 years with 0.1 ppb (50 ng/L glyphosate equivalent dilution; 4 ng/kg body weight/day daily intake) Roundup GBH formulation showed signs enhanced injury as indicated anatomorphological, blood/urine biochemical changes transcriptome profiling. Here present multiomic study combining...
There is intense debate on whether glyphosate can inhibit the shikimate pathway of gastrointestinal microorganisms, with potential health implications.
Abstract Glyphosate (GLY), the most widely used herbicide active ingredient (AI) in world, is frequently detected aquatic environments where it can affect non-target organisms. Globally, more than 2000 commercial GLY-based herbicides (GBHs) are to control weeds. Non-target organisms exposed complex pesticide formulations under real environmental conditions, but co-formulants contained GBHs classified as so-called inert and inactive ingredients terms of their biological effects. The main...
Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH, such as Roundup, pose a particular health risk to liver and kidneys although low environmentally relevant doses have not been examined. To address this issue, 2-year study in rats administering 0.1 ppb Roundup (50 ng/L glyphosate equivalent) via drinking water (giving daily intake of 4 ng/kg bw/day glyphosate) was conducted. A marked increased incidence anatomorphological...
The safety, including the endocrine disruptive capability, of glyphosate-based herbicides (GBHs) is a matter intense debate. We evaluated estrogenic potential glyphosate, commercial GBHs and polyethoxylated tallowamine adjuvants present as co-formulants in GBHs. Glyphosate (≥10,000 μg/L or 59 μM) promoted proliferation estrogen-dependent MCF-7 human breast cancer cells. also increased expression an estrogen response element-luciferase reporter gene (ERE-luc) T47D-KBluc cells, which was...
Plasticizers with estrogenic activity, such as bisphenol A (BPA), have potential adverse health effects in humans. Due to mounting evidence of these effects, BPA is being phased out and replaced by other variants “BPA-free” products. We compared activity 6 analogues [bisphenol S (BPS); F (BPF); AP (BPAP); AF (BPAF); Z (BPZ); B (BPB)] 3 human breast cancer cell lines. Estrogenicity was assessed (10−11–10−4 M) growth an estrogen receptor (ER)-mediated proliferation assay, the induction...
The safety profile of the herbicide glyphosate and its commercial formulations is controversial. Reviews have been published by individuals who are consultants employees companies commercializing glyphosate-based herbicides in support glyphosate's reapproval regulatory agencies. These authors conclude that safe at levels below permissible limits. In contrast, reviews conducted academic scientists independent industry report toxic effects limits, as well shortcomings current evaluation risks...
A growing body of research suggests that dysbiosis the gut microbiota induced by environmental pollutants, such as pesticides, could have a role in development metabolic disorders. We examined long-term effects 3 doses Roundup(R) herbicide (made glyphosate and formulants) on male female Sprague-Dawley rats. total 141 bacteria families were identified 16S sequencing analysis approach. An OPLS-DA revealed an increased Bacteroidetes family S24-7 decreased Lactobacillaceae 8 out 9 females...
Whether glyphosate-based herbicides (GBHs) are more potent than glyphosate alone at activating cellular mechanisms, which drive carcinogenesis remain controversial. As GBHs cytotoxic glyphosate, we reasoned they may also be capable of carcinogenic pathways. We tested this hypothesis by comparing the effects with Roundup both in vitro and vivo. First, was compared representative GBHs, namely MON 52276 (European Union), 76473 (United Kingdom), 76207 States) using mammalian stem cell-based...
Abstract Glyphosate (GLY), the most widely used herbicide in world, is frequently detected various environmental matrices, including soil, foundation of agriculture. In practice, more than 2000 GLY-based (GBH) products are used, consisting one or active ingredients (AIs) and so-called “inert” co-formulants that increase efficacy AIs. However, focus ecotoxicological assessments mainly on AIs, while organisms exposed to complex pesticide formulations under real-world conditions. Overall,...
Dietary (poly)phenols have received great interest due to their potential role in the prevention and management of non-communicable diseases. In recent years, a high inter-individual variability biological response has been demonstrated, which could be related (poly)phenol gut microbial metabolism existing within individuals. An interplay between microbiota exists, with being metabolised by metabolites modulating diversity composition. A number metabolising phenotypes or metabotypes...