A5057401289- Prion Diseases and Protein Misfolding
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Mesenchymal stem cell research
- Boron and Carbon Nanomaterials Research
- Extracellular vesicles in disease
- Boron Compounds in Chemistry
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Head and Neck Surgical Oncology
- Animal Genetics and Reproduction
- Pharmacological Effects and Toxicity Studies
- Neurological diseases and metabolism
- Nuclear Physics and Applications
- Alzheimer's disease research and treatments
University of Genoa
2020-2024
Abstract Background Meningiomas are mainly benign brain tumors, although about 20% of histologically cases clinically aggressive and recur after resection. We hypothesize that meningioma invasiveness recurrence may be related to the presence cancer stem cells their high responsiveness CXCL12-CXCR4/CXCR7 chemokine axis. The aim this study was isolate from human samples, characterize them for biological features malignant behavior, identify role CXCR4/CXCR7 in these processes. Methods...
Cellular prion protein (PrPC) is a widely expressed membrane-anchored glycoprotein, which has been associated with the development and progression of several types human malignancies, controlling cancer stem cell activity. However, different molecular mechanisms regulated by PrPC in normal tumor cells have not characterized yet. To assess role patient-derived glioblastoma (GSC)-enriched cultures, we generated lines was either overexpressed or down-regulated investigated, 2D 3D its...