A5008500895- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Forensic Toxicology and Drug Analysis
- Metabolomics and Mass Spectrometry Studies
- Skin and Cellular Biology Research
- Psychedelics and Drug Studies
- Alcohol Consumption and Health Effects
- Mercury impact and mitigation studies
- Mass Spectrometry Techniques and Applications
- Pesticide Exposure and Toxicity
- Analytical Chemistry and Chromatography
- Heavy Metal Exposure and Toxicity
- Biochemical effects in animals
- Hormonal and reproductive studies
- Coenzyme Q10 studies and effects
- Pharmacogenetics and Drug Metabolism
- Advanced oxidation water treatment
- Environmental Toxicology and Ecotoxicology
- Per- and polyfluoroalkyl substances research
- Sulfur Compounds in Biology
- Parkinson's Disease Mechanisms and Treatments
- Lipid metabolism and biosynthesis
- Nicotinic Acetylcholine Receptors Study
- Potato Plant Research
Florida International University
2014-2024
Faculty of Public Health
2016
University at Albany, State University of New York
1993-2009
Albany State University
1992-2009
University of Massachusetts Amherst
2008-2009
New York State Department of Health
1982-1997
Wadsworth Center
1985-1997
Albany Medical Center Hospital
1978-1983
Union University
1978
Union College
1978
Children are commonly exposed at background levels to several ubiquitous environmental pollutants, such as lead and persistent organic that have been linked neurologic endocrine effects. These effects prompted concern about alterations in human reproductive development. Few studies examined the of these toxicants on sexual maturation found general population, none has able examine multiple toxicant exposures. The aim current investigation was relationship between attainment menarche 6...
Endogenous electrophiles, ionizing and non-ionizing radiation, hazardous chemicals present in the environment diet can damage DNA by forming covalent adducts. adducts form critical cancer driver genes and, if not repaired, may induce mutations during cell division, potentially leading to onset of cancer. The detection quantification specific are some first steps studying their role carcinogenesis, physiological conditions that lead production, risk assessment exposure genotoxic chemicals....
Biological markers, or biomarkers, reflect molecular and cellular alterations that occur along the temporal mechanistic pathways connecting exposure to toxic chemicals physical agents presence risk of clinical disease. Biomarkers include a vast array measurements exposure, effect, and/or susceptibility. The development validation potential biomarkers is long-term endeavor proceeds from basic research pilot human studies full-scale epidemiological investigations. past decade has seen...
Sufficient toxicological data are now available to permit use of conventional risk assessment techniques estimate the hazards associated with human exposure 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). However, many real-world exposures involve complex mixtures dibenzodioxins, dibenzofurans, and related compounds. Historical approaches on such have ranged from ignoring all compounds except 2,3,7,8-TCDD itself assuming that potencies equal 2,3,7,8-TCDD. An alternative approach which...
It is well documented that acute exposure to high levels of persistent organic pollutants, such as polychlorinated biphenyls (PCBs), p,p'-dichlorophenyldichloroethylene (p,p'-DDE), and hexachlorobenzene (HCB), can affect human health including thyroid function. Chronic multiple toxicants common but difficult analyze, most prior studies have focused on adults or newborns, creating a gap in our understanding multitoxicant effects among adolescents.We investigated whether PCBs, p,p'-DDE, HCB,...
Since the introduction of synthetic heroin, designer drugs have been increasing in prevalence United States drug market over past few decades. Recently, 'legal highs' sold as 'bath salts' become a household term for one such class drugs. While number federal and state bans enacted, abuse these still continues. Few assays developed comprehensive detection compounds, so it is important to investigate how they may or not react presumptive screens, i.e. pre-existing commercial immunoassays. In...
Exposure to persistent organic pollutants (POPs) is known increase risk of diabetes.
Background: Concern persists over endocrine-disrupting effects of persistent organic pollutants (POPs) on human growth and sexual maturation. Potential toxicant exposures testosterone levels during puberty are not well characterized.Objectives: In this study we evaluated the relationship between toxicants [polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (p,p´-DDE), hexachlorobenzene (HCB), lead] among 127 Akwesasne Mohawk males 10 to < 17 years age with documented...
Abstract Aptamers are promising biorecognition elements for sensors. However, aptamer‐based assays often lack the requisite levels of sensitivity and/or selectivity because they typically employ structure‐switching aptamers with attenuated affinity utilize reporters that require aptamer labeling or which susceptible to false positives. Dye‐displacement offer a label‐free, sensitive means overcoming these issues, wherein target binding liberates dye is complexed aptamer, producing an optical...
Polychlorinated biphenyl (PCB) exposure has been linked to a variety of toxic effects in animal experiments and certain human case reports epidemiologic studies. A total 209 individual PCB congeners are possible, based on chlorination level ring substitution pattern. Commercial PCBs complex mixture congeners, over 75 these have reported be present tissues at widely varying levels. Because the biologic activity is function extent pattern chlorine substitution, "congener-specific" analysis...