A5101828517- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Fluid Dynamics and Turbulent Flows
- Dementia and Cognitive Impairment Research
- Gas Dynamics and Kinetic Theory
- Breast Cancer Treatment Studies
- Helicobacter pylori-related gastroenterology studies
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Noise Effects and Management
- Health, Environment, Cognitive Aging
- Lung Cancer Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Medicinal Plant Pharmacodynamics Research
- Breast Implant and Reconstruction
- Particle Dynamics in Fluid Flows
- Spinal Cord Injury Research
- Ideological and Political Education
- Polyomavirus and related diseases
- Genomics and Chromatin Dynamics
- Transplantation: Methods and Outcomes
- Diet, Metabolism, and Disease
Shanghai Medical College of Fudan University
2018-2025
Fudan University Shanghai Cancer Center
2015-2025
Shanghai Clinical Research Center
2023-2025
Wuhan University of Science and Technology
2010-2024
Wenzhou Medical University
2014-2024
The First People's Hospital of Xiaoshan District, Hangzhou
2024
Wuhan University
2023-2024
Duke Kunshan University
2023-2024
Guizhou University
2023
Alzheimer’s Disease Neuroimaging Initiative
2023
Abstract: This article is the series of methodology clinical prediction model construction (total 16 sections this series). The first section mainly introduces concept, current application status, methods and processes, classification models, necessary conditions for conducting such researches problems currently faced. second episode these concentrates on screening method in multivariate regression analysis. third models based Logistic Nomogram drawing. fourth Cox proportional hazards fifth...
Therapeutic resistance represents a bottleneck to treatment in advanced gastric cancer (GC). Ferroptosis is an iron-dependent form of non-apoptotic cell death and associated with anti-cancer therapeutic efficacy. Further investigations are required clarify the underlying mechanisms. Ferroptosis-resistant GC lines constructed. Dysregulated mRNAs between ferroptosis-resistant parental identified. The expression SOX13/SCAF1 manipulated where relevant biological molecular analyses performed....
Abstract Background and Objective In recent years, various laser systems have been introduced into the field of laser‐assisted endodontic therapy. The aim this study was to evaluate bactericidal effect Nd:YAG, Er:YAG, Er,Cr:YSGG radiation, antimicrobial photodynamic therapy (aPDT) in experimentally infected root canals compared with standard treatment 5.25% sodium hypochlorite (NaClO) irrigation. Materials Methods Two hundred twenty from extracted human teeth (contaminated Enterococcus...
Abstract INTRODUCTION The prevalence and risk factors for subjective cognitive decline (SCD) its correlation with objective cognition (OCD) among community‐dwelling older adults is inconsistent. METHODS Older underwent neuropsychological clinical evaluations to reach a consensus on diagnoses. RESULTS This study included 7486 without mild impairment dementia (mean age: 71.35 years [standard deviation = 5.40]). sex‐, age‐, residence‐adjusted SCD was 58.33% overall (95% confidence interval:...
The potential benefit of combining intracranial effective systemic therapy with radiotherapy for patients breast cancer brain metastases remains unclear.
Somatic mutations of U2AF1 gene have recently been identified in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). In this study, we analyzed the frequency clinical impact a cohort 452 Chinese patients with neoplasms. Mutations were found 2.5% (7/275) AML 6.3% (6/96) MDS patients, but none 81 CML. All heterozygous missense affecting codon S34 or Q157. There was no significant association mutation blood parameters, FAB subtypes, karyotypes other AML. The overall survival (OS)...
MK-8776 is a recently described inhibitor that highly selective for checkpoint kinase 1 (Chk1), which can weaken the DNA repair capacity in cancer cells to achieve chemo-sensitization. A number of studies show enhances cytotoxicity hydroxyurea and gemcitabine without increasing normal tissue toxicities. Thus far, there no evidence be used as radiotherapy sensitization agent. In this study, we investigated effects on radiosensitivity 3 human triple-negative breast (TNBC) cell lines...
Obesity and constipation are both global problems, but the factors associated with in individuals obesity currently understudied. The aim of our study was to explore people obesity.
Abstract The aim of this study was to explore the independent prognostic factors related postoperative recurrence‐free survival ( RFS ) in patients with breast phyllodes tumors PTB s). A retrospective analysis conducted Fudan University Shanghai Cancer Center. According histological type, benign s were classified as a low‐risk group, while borderline and malignant high‐risk group. Cox regression model adopted identify affecting two groups, nomogram generated predict at 1, 3, 5 years. Among...
Resveratrol (RES) is a polyphenolic compound, and our previous results have demonstrated its neuroprotective effect in series of animal models. The aim this study was to investigate potential on nonalcoholic fatty liver disease (NAFLD) rat model. parameters function glucose lipid metabolism were measured. Behavior performance observed via the open field test (OFT), sucrose preference (SPT), elevated plus maze (EPM), forced swimming (FST), Morris water (MWM). protein expression levels Copine...
Transfer RNAs (tRNAs), the essential adapter molecules in protein translation, undergo various post-transcriptional modifications. These modifications play critical roles regulating tRNA folding, stability, and codon-anticodon interactions, depending on modified position. Methods for detecting nucleosides tRNAs include isotopic labeling combined with chromatography, antibody-based techniques, mass spectrometry, high-throughput sequencing. Among these, high-performance liquid chromatography...
The clinical significance of multi-kingdom skin microbiota in acute radiation dermatitis (ARD) is not well understood. We hypothesized that associated with ARD patients breast cancer (BC) undergoing therapy (RT) after reconstructive surgery. A total 412 samples from 103 patients, taken before and RT, both the treated contralateral healthy sides, were analyzed using bacterial 16S ribosomal RNA (rRNA) V3-V4 region fungal rRNA internal transcribed spacer (ITS) sequencing. was graded Toxicity...
This paper is a theoretical modeling study of the nonlinear transport momentum and energy in hypersonic rarefied flow past sharp leading-edge flat plate at zero angle attack. A characteristic parameter introduced to describe non-Newtonian shear non-Fourier heat transfer features near-continuum regime via approximate analyses on corresponding terms from Burnett equation. Modified formulas based are proposed quantitatively predict skin friction flux along plate, Reynolds analogy proved still...
To build the triple-negative breast cancer (TNBC) radiation resistance model in vitro and vivo, screen molecular markers that related to resistance.We used X-ray irradiate MDA-MB-231 cells repeatedly radioresistant cell (231-RR), then select one gemcitabine-resistance of (231-GEM). We differentially expressed genes these lines. Then, we would 2 them associated with DNA damage repair or cycle, RNAi lentivirus vector knock down gene. also X-rays exposure TNBC tumor xenograft radioresistance...
The gene for hepatitis B virus X protein (HBx) comprises the smallest open reading frame in HBV genome, and product can activate various cell signaling pathways regulate apoptosis, among other effects. However, different types under external conditions, its mechanism of action differs. In present study, effect HBx on viability apoptosis mouse podocyte clone 5 (MPC5) cells was investigated. were transfected with using pEX plasmid, real-time quantitative PCR western blot analysis used to test...