A5026227665- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurotransmitter Receptor Influence on Behavior
- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Genetic Associations and Epidemiology
- Cholinesterase and Neurodegenerative Diseases
- Health, Environment, Cognitive Aging
- Mobile Health and mHealth Applications
- Health disparities and outcomes
- Tryptophan and brain disorders
- Treatment of Major Depression
- Frailty in Older Adults
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Intergenerational Family Dynamics and Caregiving
- Technology Use by Older Adults
- Analytical Methods in Pharmaceuticals
- Sleep and related disorders
- Bioinformatics and Genomic Networks
- Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
Utah State University
2015-2024
Nia Association
2022
ID Genomics (United States)
2022
University of Utah
2019
Huntsman Cancer Institute
2019
Brigham Young University
2019
George E. Wahlen Department of VA Medical Center
2019
Boston University
2007-2018
Framingham Heart Study
2018
Institute for Neurodegenerative Disorders
2018
Abstract Background Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal course the community. Objective To estimate point and 5‐year period prevalence of neuropsychiatric an incident sample 408 dementia participants from Cache County Study. Methods The Inventory assessed at baseline 1.5 years, 3.0 4.1 5.3 years. Point prevalence, mean symptom severity each time were estimated. Results for delusions was 18% 34–38% during last three visits;...
To determine whether baseline hearing loss increases cognitive decline and risk for all-cause dementia in a population of elderly individuals.Longitudinal cohort study.Community-based, outpatient.Men women aged 65 years or older without at baseline.All subjects completed the Modified Mini-Mental Status Exam (3MS-R) over 3 triennial follow-up visits. Hearing (HL) was based on observation difficulties during testing interview. Incident determined by clinical assessment expert...
Objective: Little is known about factors influencing the rate of progression Alzheimer’s dementia. Using data from Cache County Dementia Progression Study, authors examined link between clinically significant neuropsychiatric symptoms in mild dementia and to severe or death. Method: The Study a longitudinal study incident cases this condition. Survival analyses included unadjusted Kaplan-Meier plots multivariate Cox proportional hazard models. Hazard ratio estimates controlled for age at...
<h3>Objective</h3> The association of primary oncologist specialty, medical oncology versus gynecologic oncology, on intensity care at the end life in elderly patients with cancer is unclear. <h3>Methods</h3> This retrospective cohort study used Surveillance, Epidemiology and End Results-Medicare (SEER-M) data. Subjects were fee-for-service Medicare enrollees aged 65 years older who died a between January 2006 December 2015. outcome was composite score for high-intensity received last month...
Vascular risk factors for Alzheimer disease (AD) and vascular dementia (VaD) have been evaluated; however, few studies compared risks by subtypes sex. We evaluated relationships between cardiovascular (hypertension, high cholesterol, diabetes mellitus, obesity), events (stroke, coronary artery bypass graft surgery, myocardial infarction), subsequent of AD VaD sex in a community-based cohort 3264 Cache County residents aged 65 or older. Cardiovascular history was ascertained self-report...
To examine the effects of caring for a spouse with dementia on caregiver's risk incident dementia.Population-based study in spouses persons dementia.Rural county northern Utah.Two thousand four hundred forty-two subjects (1,221 married couples) aged 65 and older.Incident was diagnosed 255 subjects, onset defined as age when subject met Diagnostic Statistical Manual Mental Disorders, Third Edition, Revised, criteria dementia. Cox proportional hazards regression tested effect time-dependent...
To examine 3-year rates of conversion to dementia, and risk factors for such conversion, in a population-based sample with diverse types cognitive impairment.All elderly (aged 65 or older) residents Cache County, UT, were invited undergo two waves dementia screening assessment. Three-year follow-up data available 120 participants who had some form mild impairment at baseline. Of these, 51 been classified baseline prodromal Alzheimer disease (proAD), 69 other syndromes (CS).Three-year 46%...
Applying Rusbult's investment model of dyadic relationships, we examined the effect caregiver–care recipient relationship closeness (RC) on cognitive and functional decline in Alzheimer's disease. After diagnosis, 167 participants completed up to six visits, observed over an average 20 months. Participants were 64% women, had a mean age 86 years, dementia duration 4 years. Caregiver-rated was measured using six-item scale. In mixed models adjusted for severity, dyads with higher levels (p <...
Objective The use of psychotropic medications in Alzheimer's disease (AD) has been associated with both deleterious and potentially beneficial outcomes. We examined the longitudinal association medication cognitive, functional, neuropsychiatric symptom (NPS) trajectories among community‐ascertained incident AD cases from Cache County Dementia Progression Study. Methods A total 230 participants were followed for a mean 3.7 years. Persistency index (PI) was calculated all antidepressants,...
Nutritional status may be a modifiable factor in the progression of dementia. We examined association nutritional and rate cognitive functional decline U.S. population-based sample. Study design was an observational longitudinal study with annual follow-ups up to 6 years o f 292 persons dementia (72% Alzheimer's disease, 56% female) Cache County, UT using Mini-Mental State Exam (MMSE), Clinical Dementia Rating Sum Boxes (CDR-sb), modified Mini Assessment (mMNA). mMNA scores declined by...
Prevalence of Alzheimer's disease (AD) is higher for women, possibly influenced by sex-dependent effects the estrogen. We examined association between estrogen and cognitive decline in over 2,000 older adult women a 12-year population-based study Cache County, Utah.The baseline sample included 2,114 (mean age = 74.94 y, SD 6.71) who were dementia-free at completed women's health questionnaire, asking questions regarding reproductive history hormone therapy (HT). Endogenous exposure (EEE) was...
<b><i>Objective:</i></b> To examine the relative risk and population attributable (PAR) of death with dementia varying type severity other factors in a exceptional longevity. <b><i>Methods:</i></b> Deaths were monitored over 5 years using vital statistics records newspaper obituaries 355 individuals prevalent 4,328 without Cache County, UT. Mean age was 83.3 (SD 7.0) 73.7 6.8) without. History coronary artery disease, hypertension, diabetes, life-shortening illness ascertained from...
Epidemiologic studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may be useful for the prevention of Alzheimer disease (AD). By contrast, clinical trials not supported NSAID use to delay or treat AD. Few evaluated cognitive trajectories users over time.Residents Cache County, UT, aged 65 older on January 1, 1995, were invited participate in study. At baseline, participants provided a detailed inventory their medications and completed revised Modified Mini-Mental State...
Objectives Late‐life disability in activities of daily living (ADL) is theorized to be driven by underlying cognitive and/or physical impairment, interacting with psychological and environmental factors. Although we expect that deficits would explain associations between ADL dementia risk, the current study examined as a predictor future after controlling for global status. Methods The population‐based Cache County Memory Study ( N = 3547) assessed individuals four triennial waves (average...
While age and the APOE ε4 allele are major risk factors for Alzheimer's disease (AD), a small percentage of individuals with these exhibit AD resilience by living well beyond 75 years without any clinical symptoms cognitive decline. We used over 200 "AD resilient" an innovative, pedigree-based approach to identify genetic variants that segregate resilience. First, we performed linkage analyses in pedigrees resilient statistical excess deaths. Second, whole genome sequences candidate SNPs...
<h3>Objective</h3> The inherited component for Alzheimer disease (AD) risk has focused on close relatives; consideration of the full family history may improve accuracy and utility estimates. <h3>Methods</h3> A population resource including a genealogy Utah pioneers from 1800s linked to death certificates was used estimate relative AD based specific constellations, first- third-degree relatives. <h3>Results</h3> Any affected first-degree relatives (FDR) significantly increased (≥1 FDRs: [RR]...
Background: Health education and behavior change programs targeting specific risk factors have demonstrated their effectiveness in reducing the development of future diseases. Alzheimer disease (AD) shares many same factors, most which can be addressed via change. It is therefore theorized that a intervention these would likely result favorable rates AD prevention. Objective: The objective this study was to reduce developing AD, while short term promoting vascular health, through Methods: an...