A5091402777- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Peroxisome Proliferator-Activated Receptors
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Cytokine Signaling Pathways and Interactions
- Phagocytosis and Immune Regulation
- Cardiovascular Function and Risk Factors
- Rheumatoid Arthritis Research and Therapies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone health and treatments
- Inflammatory Biomarkers in Disease Prognosis
- IL-33, ST2, and ILC Pathways
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- CAR-T cell therapy research
- interferon and immune responses
- Cardiac tumors and thrombi
- Bone and Joint Diseases
Yale New Haven Hospital
2024
Yale University
2022-2024
Beth Israel Deaconess Medical Center
2016-2023
Harvard University
2016-2023
Hadassah Medical Center
2021-2022
National and Kapodistrian University of Athens
2013-2018
Weatherford College
2013
PD-1, a T cell checkpoint receptor and target of cancer immunotherapy, is also expressed on myeloid cells. The role myeloid-specific versus cell-specific PD-1 ablation antitumor immunity has remained unclear because most studies have used either PD-1-blocking antibodies or complete KO mice. We generated conditional allele, which allowed (PD-1f/fLysMcre) (PD-1f/fCD4cre) targeting Pdcd1 gene. Compared with ablation, more effectively decreased tumor growth. found that granulocyte/macrophage...
Abstract Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a substantial protumorigenic immune component. Knowledge of the GBM microenvironment during tumor evolution and standard care treatments limited. Using single-cell transcriptomics flow cytometry, we unveiled large-scale comprehensive longitudinal changes in cell composition throughout progression epidermal growth factor receptor-driven genetic mouse model. We identified subsets proinflammatory...
Abstract The inhibitory receptor PD-1 suppresses T cell activation by recruiting the phosphatase SHP-2. However, mice with a T-cell-specific deletion of SHP-2 do not have improved antitumor immunity. Here we showed that conditional targeting in myeloid cells, but had diminished tumor growth. RNA sequencing (RNA-seq) followed gene set enrichment analysis indicated presence polymorphonuclear myeloid-derived suppressor cells and tumor-associated macrophages (TAMs) enriched expression profiles...
Abstract Background Clonal hematopoiesis of indeterminate potential (CHIP) has been shown to increase all-cause mortality and risk cardiomyopathy in patients with solid malignancies. CHIP also T cell activation heart failure patients. It is unclear whether can affect the immune checkpoint inhibitor (ICI) myocarditis cancer treated immunotherapy. Methods We enrolled tumors a prospective study, determined status at time enrollment through blood whole exome sequencing, assessed incidence ICI...
The respiratory tract is in direct contact with the outside environment and requires a precisely regulated immune system to provide protection while suppressing unwanted reactions environmental antigens. Lungs host several populations of innate adaptive cells that surveillance but also mediate protective responses. These cells, which keep healthy pulmonary balance, participate pathological conditions such as asthma, infections, autoimmune diseases, cancer. Selective expression surface...
Abstract Metabolism is a common cellular feature. Cancer creates suppressive microenvironment resulting in inactivation of antigen-specific T cells by metabolic reprogramming. Development approaches that enhance and sustain physiologic properties cell metabolism to prevent promote effector function the tumor an urgent need for improvement cell-based cancer immunotherapies.
Summary Obesity is a leading risk factor for progression and metastasis of many cancers 1,2 , yet can also promote improved survival some 3-5 enhance responses to immune checkpoint blockade therapies 6-8 . The role the system in obesity-cancer connection how obesity influences immunotherapy, however, remain unclear. While PD-1 expression by macrophages has been described 9-12 we found that selectively induced on directly impaired macrophage function. Single cell RNA sequencing murine...
Objective: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease that necessitates multidisciplinary approach. The aim of our study to assess the awareness and depth knowledge SLE in medical students. By identifying shortcomings lupus-related education, results can be generalized other processes require care from multiple specialties. Methods: We surveyed undergraduate students two Greek schools using structured questionnaire. questionnaire consisted parts. Part A assessed...