A5116719645- Dietary Effects on Health
- Regulation of Appetite and Obesity
- Immune Cell Function and Interaction
Helmholtz Zentrum München
2025
German Center for Diabetes Research
2025
Heinrich Heine University Düsseldorf
2025
Deutsches Diabetes-Zentrum e.V.
2025
Abstract The hypothalamus in the central nervous system (CNS) has important functions controlling systemic metabolism. A calorie-rich diet triggers CNS immune activation, impairing metabolic control and promoting obesity Type 2 Diabetes (T2D), but mechanisms driving hypothalamic activation remain unclear. Here we identify regulatory T cells (Tregs) as key modulators of responses. In mice, environments activate CD4 + cells, infiltrating macrophages microglia while reducing Tregs. mRNA...