A5051314867- Fungal and yeast genetics research
- Fungal Biology and Applications
- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Slime Mold and Myxomycetes Research
- Microbial Natural Products and Biosynthesis
- Wheat and Barley Genetics and Pathology
- Mycorrhizal Fungi and Plant Interactions
- Protist diversity and phylogeny
- Species Distribution and Climate Change
- Corporate Governance and Law
- Mycotoxins in Agriculture and Food
- Law and Political Science
- Microbial Metabolic Engineering and Bioproduction
- Fermentation and Sensory Analysis
- Entomopathogenic Microorganisms in Pest Control
- Insect Pest Control Strategies
- Medical and Health Sciences Research
- Toxin Mechanisms and Immunotoxins
- Wildlife Ecology and Conservation
- Rangeland and Wildlife Management
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Nematode management and characterization studies
Johannes Gutenberg University Mainz
2016-2025
Institut für Biotechnologie und Wirkstoff-Forschung
2013-2016
University of Kaiserslautern
2016
Vestas (Denmark)
1986
Bioactivity-guided isolation identified the main antifungal compounds produced by Acrophialophora levis as new polyhydroxy-polyketides acrophialocinol (1) and acrophialocin (2). Their biosynthesis was elucidated heterologous reconstitution in Aspergillus oryzae involves an α-ketoglutarate-dependent dioxygenase-catalyzed α-hydroxylation, resulting formation of a tertiary alcohol that is indispensable for activity. Furthermore, self-resistance toward mediated conserved RTA1-like protein...
The Magnaporthe oryzae genes FLB3 and FLB4, orthologues of the Aspergillus nidulans regulators conidiation FlbC FlbD, were inactivated. These encode C2H2 zinc finger Myb-like transcription factors, respectively, in A. nidulans. Analysis resultant mutants demonstrated that FLB4 is essential for spore formation strains lacking this gene are fluffy their colony morphology due to an inability complete conidiophore formation. Meanwhile, required normal levels aerial mycelium We identified...
Genome mining and heterologous reconstitution of biosynthetic genes in Aspergillus oryzae enabled elucidation the hitherto elusive route that produces allantofuranone (1), a bioactive natural product originally isolated from Allantophomopsis lycopodina. The core non-ribosomal peptide synthetase (NRPS)-like enzyme AlfA alf BGC polyporic acid (2) phenylpyruvic acid. In subsequent reactions, compound 2 is reductively dehydrated by bifunctional AlfC methylated AlfD to produce terferol (6). final...
The number of sustainable agriculture techniques to improve pest management and environmental safety is rising, as biological control agents are used enhance disease resistance abiotic stress tolerance in crops. Here, we investigated the capacity
A forward genetics approach was applied in order to investigate the molecular basis of morphological transition wheat pathogenic fungus Zymoseptoria tritici. Z. tritici is a dimorphic plant pathogen displaying environmentally regulated morphogenetic between yeast-like and hyphal growth. Considering infection mode tritici, switching growth essential for pathogenicity allowing host invasion through natural openings like stomata. We exploited previously developed Agrobacterium...
Across kingdoms, RNA interference (RNAi) has been shown to control gene expression at the transcriptional- or post-transcriptional level. Here, we describe a mechanism which involves both aspects: truncated transgenes, fail produce intact mRNA, induce siRNA accumulation and silencing of homologous loci in trans ciliate Paramecium We show that is achieved by co-transcriptional silencing, associated with repressive histone marks endogenous gene. This accompanied secondary accumulation,...
Abstract Background One fundamental question in biology is how the evolution of eukaryotic signaling networks has taken place. “Loss function” (lof) mutants from components high osmolarity glycerol (HOG) pathway filamentous fungus Magnaporthe oryzae are viable, but impaired osmoregulation. Results After long-term cultivation upon osmolarity, stable individuals with reestablished osmoregulation capacity arise independently each inactivated HOG pathway. This phenomenon extremely reproducible...
The ability of pathogens to signal perception and adaptation environmental changes is an important prerequisite for successful colonization the host organism. Filamentous phytopathogenic fungi, example, have cope with rapid in environment during invasive growth planta. Consequently, they evolved a range specific factors contributing facilitating invasion. In addition conserved pathways, including genes participating stress response, unique/individual within might represent determinants...
Diseases caused by dimorphic phytopathogenic and systemic fungi have markedly increased in prevalence the last decades, understanding morphogenic transition to virulent state might yield novel means of controlling fungi. The fungus Z. tritici causes significant economic impact on wheat production, yet regulation switch, a key first step successful plant colonization, is still largely unexplored this fungus. amenable suppression fungicides at switch point, identification factors provides...
"The moult of Glaucous Gull Larus hyperboreus and Iceland glaucoides in Disko, Greenland." Bird Study, 33(1), pp. 49–50
Abstract Background One fundamental question in biology is how the evolution of eukaryotic signaling networks has taken place. “Loss function” (lof) mutants from components high osmolarity glycerol (HOG) pathway filamentous fungus Magnaporthe oryzae are viable, but impaired osmoregulation. Results After long-term cultivation upon osmolarity, stable individuals with reestablished osmoregulation capacity arise independently each inactivated HOG pathway. This phenomenon extremely reproducible...
Abstract Background One fundamental question in biology is how the evolution of eukaryotic signaling networks has taken place. “Loss function” (lof) mutants from components high osmolarity glycerol (HOG) pathway filamentous fungus Magnaporthe oryzae are viable, but impaired osmoregulation. Results After long-term cultivation upon osmolarity, stable individuals with reestablished osmoregulation capacity arise independently each inactivated HOG pathway. This phenomenon extremely reproducible...
Abstract Background One fundamental question in biology is how the evolution of eukaryotic signaling networks has taken place. “Loss function” (lof) mutants from components high osmolarity glycerol (HOG) pathway filamentous fungus Magnaporthe oryzae are viable, but impaired osmoregulation. Results After long-term cultivation upon osmolarity, stable individuals with reestablished osmoregulation capacity arise independently each inactivated HOG pathway. This phenomenon extremely reproducible...