A5013162170- Osteoarthritis Treatment and Mechanisms
- Spondyloarthritis Studies and Treatments
- Meta-analysis and systematic reviews
- Gout, Hyperuricemia, Uric Acid
- Rheumatoid Arthritis Research and Therapies
- Suicide and Self-Harm Studies
- Lower Extremity Biomechanics and Pathologies
- Musculoskeletal pain and rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Knee injuries and reconstruction techniques
- Hip disorders and treatments
- Otitis Media and Relapsing Polychondritis
- Artificial Intelligence in Healthcare and Education
- Machine Learning in Healthcare
- Vasculitis and related conditions
- Inflammasome and immune disorders
- Bone and Joint Diseases
- Statistical Methods and Bayesian Inference
- Statistical Methods in Clinical Trials
- Foot and Ankle Surgery
- Musculoskeletal Disorders and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Case Reports on Hematomas
- Health Literacy and Information Accessibility
- AI in cancer detection
University of Birmingham
2024-2025
NIHR Birmingham Biomedical Research Centre
2024-2025
University of Oxford
2023-2024
Keele University
2015-2024
Nuffield Orthopaedic Centre
2023-2024
Northumbria Healthcare NHS Foundation Trust
2024
Versus Arthritis
2017-2023
The University of Sydney
2023
Midlands Partnership NHS Foundation Trust
2018-2019
Migration Institute of Australia
1997
This article aims to examine the socio-demographic characteristics associated with access and use of Internet for health-related purposes its relationship health literacy. Data were drawn from a literacy survey ( N = 1046) analysed using logistic regression. Results show strong association between literacy, internet use. Socio-demographic particularly age, education, income, perceived social isolation also predict access. Thus, in addition widening access, movement towards digitisation...
Lower health literacy is a public issue that follows social gradient, potentially reinforcing existing inequalities. However, levels of in particular populations can be unclear and are key to identifying effective interventions. This research examined Stoke-on-Trent, where 31.2% the population live areas classified amongst 10% most deprived England.A cross-sectional survey using Newest Vital Sign associations with demographic factors, lifestyle behaviours, Internet use self-rated health. The...
ObjectivesWhen developing a clinical prediction model, penalization techniques are recommended to address overfitting, as they shrink predictor effect estimates toward the null and reduce mean-square error in new individuals. However, shrinkage penalty terms ('tuning parameters') estimated with uncertainty from development data set. We examined magnitude of this subsequent impact on model performance.Study Design SettingThis study comprises applied examples simulation following methods:...
The objectives of this study were to estimate the population prevalence and distribution plantar heel pain in mid-to-older age groups, examine associations with selected health status lifestyle factors, report frequency healthcare use. Adults aged ≥50 years registered four general practices mailed a survey (n = 5109 responders). Plantar last month was defined by self-reported shading on foot manikin, as disabling if at least one function items Manchester Foot Pain Disability Index also...
The UK government reclassified gabapentin and pregabalin as 'controlled drugs' from April 2019. This study aimed to describe the trends in gabapentinoid prescribing before immediately after reclassification, Clinical Practice Research Datalink, an electronic primary care health record broadly representative of UK.Separately for pregabalin, we calculated annual incident prevalent rates year approval (April 1997 2004 respectively) September 2019, monthly (October 2017-September 2019)....
Growing evidence from pharmacovigilance data and postmortem toxicology reports highlights the misuse potential of gabapentinoids. This study aimed to investigate risk serious adverse outcomes (drug misuse, overdose, major trauma), their factors, in primary care patients who are prescribed Using UK Clinical Practice Research Datalink, a matched cohort calculated event rates separately for gabapentinoid-exposed unexposed cohorts. In exposed cohort, exposure range factors were calculated. Event...
Glucocorticoids are associated with increased fracture risk and the mainstay of treatment in polymyalgia rheumatica (PMR) giant cell arteritis (GCA). However, these conditions has not been previously quantified. The aim this study was to quantify among patients PMR GCA. A retrospective cohort conducted using primary care records from UK-based Clinical Practice Research Datalink. Individuals aged 40 years over, incident diagnoses or GCA were separately identified 1990–2004 followed up until...
An association between gout and renal disease is well-recognised but few studies have examined whether a risk factor for subsequent chronic kidney (CKD). Additionally, the impact of urate-lowering therapy (ULT) on development CKD in unclear. The objective this study was to quantify stage ≥ 3 people with ULT. This retrospective cohort using data from Clinical Practice Research Datalink (CPRD). Patients incident were identified general practice medical records 1998 2016 randomly matched 1:1...
Abstract Background Many randomized controlled trials ( RCT s) of psychosocial interventions for low back pain LBP ) have been found to only small effects on disability outcomes. Investigations the specific mechanisms that may lead an improvement in outcome therefore called for. Methods We present application causal inference approach mediation analysis using example a cluster primary care population with (sub)acute either usual GP n = 171) or minimal intervention 143). Mediation explored...
SUMMARY Generalised glycogenosis was diagnosed in Brahman cattle on 4 Queensland properties the basis of clinical observations and pathological biochemical findings. The disease presented as a problem ill‐thrift poor growth rate calves which eventually showed nervous signs. Histologically there vacuolation cells central system, heart muscular tissues. Biochemical assay liver blood mononuclear demonstrated deficiency α‐glucosidase. Parents affected had approximately half α‐glucosidase...
Objectives Despite many shared risk factors and pathophysiological pathways, the of ischaemic heart disease (IHD) myocardial infarction (MI) in interstitial lung (ILD) remains poorly understood. This lack data could be preventing patients who may benefit from screening for these cardiovascular diseases receiving it. Methods A population-based cohort study used electronic patient records Clinical Practice Research Datalink linked Hospital Episode Statistics to identify 68 572 (11 688 ILD...
Background: When developing a clinical prediction model using time-to-event data, previous research focuses on the sample size to minimise overfitting and precisely estimate overall risk. However, instability of individual-level risk estimates may still be large. Methods: We propose decomposition Fisher's information matrix examine calculate required for that aims precise fair estimates. six-step process which can used before data collection or when an existing dataset is available. Steps...
An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst patients are lacking. We aimed to precisely determine population-level absolute relative rate reporting among men with over a decade in England. utilised UK-based Clinical Practice Research Datalink identify 9653 incident age- practice-matched 38,218 controls. Absolute rates were calculated using Cox regression models. within specific time periods before after...
To determine the risk of adverse events associated with colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating allopurinol for gout.We conducted two matched retrospective cohort studies in linked UK Clinical Practice Research Datalink and Hospital Episode Statistics datasets. Adults gout (1) (2) NSAID were compared those without prophylaxis, individually by age, sex propensity to receive relevant prophylaxis. Weighted Cox proportional hazards models...
Abstract Background Hip osteoarthritis (OA) is common, painful, and disabling. Physical therapists have an important role in managing patients with hip OA; however, little known about their current management approach whether it aligns clinical guideline recommendations. Objective The objective of this study to describe United Kingdom (UK) physical therapists’ OA determine guidelines. Design design a cross-section questionnaire. Methods A questionnaire was mailed 3126 the UK that explored...
Systemic inflammatory diseases have been associated with increased risk of venous thromboembolism. We aimed to quantify the thromboembolism in patients gout, most common arthritis, and assess how disease duration, hospital admission urate-lowering therapy affect this risk.
Colchicine is commonly used to prevent flares when starting urate-lowering therapy for gout. Patients with gout are frequently concurrently prescribed other medications (such as statins) that may interact colchicine, increasing the risk of adverse events. The aim this study was describe potential prognostic factors events in patients colchicine initiating allopurinol.
Prognosis research studies (e.g. those deriving prognostic models or examining potential predictors of outcome) often collect information on time-varying after their intended moment use, sometimes using a measurement method different to that which would be used. We aimed illustrate how estimates predictor-outcome associations and model performance obtained from such may differ at the earlier, use.We analysed data two primary care cohorts patients consulting for non-inflammatory...
Despite little evidence that analgesics are effective in inflammatory arthritis (IA), studies report substantial opioid prescribing. The extent this applies to other is uncertain. We undertook a comprehensive evaluation of analgesic prescribing patients with IA the Clinical Practice Research Datalink Aurum evaluate this.