A5067206334- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Connective tissue disorders research
- Hip disorders and treatments
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Bone health and osteoporosis research
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- Vitamin D Research Studies
- Platelet Disorders and Treatments
- Advanced Technologies in Various Fields
- Growth Hormone and Insulin-like Growth Factors
- High Altitude and Hypoxia
- Ultrasound Imaging and Elastography
- Vitamin C and Antioxidants Research
- Lymphatic System and Diseases
- Bone fractures and treatments
- Advanced Image Fusion Techniques
- Blood transfusion and management
- Cardiac and Coronary Surgery Techniques
- Lower Extremity Biomechanics and Pathologies
- Thyroid Disorders and Treatments
- Smart Systems and Machine Learning
- TGF-β signaling in diseases
Chinese University of Hong Kong
2014-2025
Prince of Wales Hospital
2024
Sinai Hospital
2011
Radiation exposure with repeated radiography required at follow-up poses serious health concerns for scoliosis patients. Although spinous process angle (SPA) measurement of spinal curvatures ultrasound has been reported promising results, an evidence-based account on its accuracy translational application remains undefined. This prospective study involved 952 idiopathic patients (75.7% female, mean age 16.7 ± 3.0 y, Cobb 28.7 11.6°). Among 1432 curves (88.1%) detected by ultrasound, there...
Many reports had been received on the application of antifibrinolytic medications spinal corrective surgery and surgical outcome evaluations its efficacy reducing blood loss. This study aimed to assess tranexamic acid (TXA) in operative loss during posterior fusion for treatment severe adolescent idiopathic scoliosis (AIS). A retrospective cohort was carried out 90 (TXA = 55, Control 35) AIS girls undergoing surgery. Patients TXA group used as an agent reduce loss, while control did not....
Background: Accurate skeletal maturity assessment is important to guide clinical evaluation of idiopathic scoliosis, but commonly used methods are inadequate or too complex for rapid use. The objective the study was propose a new simplified staging method, called thumb ossification composite index (TOCI), based on pattern 2 epiphyses and adductor sesamoid bone; determine its accuracy in predicting maturation when compared with Sanders system (SSMS); validate interrater intrarater...
The problem of predicting loss in body height due to scoliosis especially adolescent idiopathic (AIS) has been investigated for over 50 years. corrected is required make appropriate lung function and other anthropometry assessments. Most existing formulae estimate through different regression models. Method: A new trigonometric model was developed based on the Cobb angle (α) apical vertebral translation (AVT) coronal plane. By using this model, a formula derived tangent triangle Scoliosis....
Adolescent idiopathic scoliosis (AIS) is a prevalent spinal deformity occurring during peripubertal growth period that affects 1‐4% of adolescents globally without clear etiopathogenetic mechanism. Low bone mineral density an independent and significant prognostic factor for curve progression. Currently, the cause underlying low mass in AIS remains elusive. Osteocytes play important role metabolism homeostasis, but its has not been studied. In present study, iliac tissues were harvested from...
Adolescent idiopathic scoliosis (AIS) patients have lower physical activity levels than normal adolescents, and there is an association with poorer bone muscle health. This study evaluated the effects of a home-based exercise intervention (E-Fit) on mineral density (BMD), function, quality life (QoL) in AIS-affected girls. A total 40 AIS females aged 11 to 14 years were randomly assigned E-Fit or control group. The group performed modified 7-min high-intensity interval training (HIIT) 5 days...
Background: The new simplified thumb ossification composite index (TOCI) based on of the epiphyses and adductor sesamoid has demonstrated simplicity, excellent reliability, high accuracy for predicting skeletal maturity, comparable with Sanders maturity system (SSMS). It was our belief that, because terminology SSMS been commonly used prediction in idiopathic scoliosis publications over past decade, clinical applicability TOCI would increase if stages 2 systems were found to be...
Prospective randomized controlled trials and long-term studies are essential future directions for building -evidence-based practices in developmental dysplasia of the hip (DDH), however, sufficient attrition data (> 20%) can introduce bias deteriorating research quality. Pelvic radiography is synonymous with DDH assessment so -Gonadal Shield (GS) recommendations pelvic radiography. -Nonetheless, losses to diagnostic information inadequate protection have been increasingly implicated GS...
The EOS-imaging system is increasingly adopted for clinical follow-up in scoliosis with the advantages of simultaneous biplanar imaging spine an erect position. Skeletal maturity assessment using a hand radiograph essential adjunct to spinal radiography follow-up. This study aims at testing feasibility and validity newly proposed EOS workflow sequential spine-hand skeletal bracing recommendation.EOS radiographs from patients diagnosis idiopathic scoliosis, including both sexes age range ten...
Introduction: Bracing is one of the first-line treatment for early-onset idiopathic scoliosis (EOIS) to control curves from progression. This study aimed explore determinants that govern bracing effectiveness in EOIS. Methods: One hundred and eleven patients with EOIS (mean age 8.6 ± 1.25 at diagnosis) received had a final follow-up beyond skeletal maturity were identified records between 1988 2021. Demographic data clinical features spinal curvature obtained correlation analyses determine...
Abstract Bone densitometry revealed low bone mass in patients with adolescent idiopathic scoliosis (AIS) and its prognostic potential to predict curve progression. Recent studies showed differential circulating miRNAs AIS but their diagnostic links have not been well-documented. The present study aimed compare miRNA profiles tissues collected from non-scoliotic subjects, explore if the selected candidates could be useful biomarkers for AIS. Microarray analysis identified miR-96-5p being most...
To report whether Bone Ninja (BN) is a reliable tool to teach the reverse planning method (RPM) for implantable intramedullary (IM) limb-lengthening devices and deformity correction surgery.Motorised fully lengthening have been gaining popularity all over world procedures. Multiple advantages demonstrated external fixator-controlled lengthening. Mechanical axis deviation may result if careful preoperative surgical intervention are not completed femur cases. The RPM proposed by Baumgart has...
Low bone mineral density and impaired quality have been shown to be important prognostic factors for curve progression in adolescent idiopathic scoliosis (AIS). There is no evidence-based integrative interpretation method analyze high-resolution peripheral quantitative computed tomography (HR-pQCT) data AIS. This study aimed (1) utilize unsupervised machine learning cluster microarchitecture phenotypes on HR-pQCT parameters girls with AIS, (2) assess the phenotypes' risk of surgical...
Ultrasound curve angle (UCA) measurement provides a radiation-free and reliable evaluation for scoliosis based on ultrasound imaging. However, degraded image quality, especially in difficult-to-image patients, can prevent clinical experts from making confident measurements, even leading to misdiagnosis. In this paper, we propose multi-stage enhancement framework that models high-quality distribution via diffusion-based model. Specifically, integrate the underlying morphological information...
Previous studies have reported abnormal muscle morphology and functions in patients with adolescent idiopathic scoliosis (AIS). To answer whether such abnormalities could be reflected their circulation clinical implication for predicting curve progression to the surgical threshold, this preliminary study explored presence of baseline muscle-related proteins association progression. Plasma samples were collected at first visit AIS, divided into non-progressive or progressive groups (N = four...
Background: Offering brace for moderately suffering adolescent idiopathic scoliosis (AIS) patients is a recognized intervention to control further curve progression, and the treatment period varies from each patient. Some AIS required wear longer than expected with different clinical reasons. Health-related quality of life (HRQOL) who have undergone bracing 2 nd year 5 th has not been discussed. The aim this study evaluate HRQOL between their using Scoliosis Research Society-22 (SRS-22)...