A5021127724- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Sleep and Wakefulness Research
- Sleep and related disorders
- Bipolar Disorder and Treatment
- Healthcare Decision-Making and Restraints
- Psychiatric care and mental health services
- Hearing Loss and Rehabilitation
- Advanced MRI Techniques and Applications
- Noise Effects and Management
- Hearing, Cochlea, Tinnitus, Genetics
- Transcranial Magnetic Stimulation Studies
- Arctic and Russian Policy Studies
- Cannabis and Cannabinoid Research
- Anesthesia and Sedative Agents
- Functional Brain Connectivity Studies
- Coastal and Marine Management
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tryptophan and brain disorders
- Forensic Toxicology and Drug Analysis
- Biomedical and Chemical Research
- Epilepsy research and treatment
- Poisoning and overdose treatments
- Anesthesia and Neurotoxicity Research
- Neurotransmitter Receptor Influence on Behavior
Medical University of Vienna
2016-2025
Comprehensive Cancer Center Vienna
2024-2025
Bethlem Royal Hospital
2023
South London and Maudsley NHS Foundation Trust
2023
University of Lausanne
2023
Klinik und Poliklinik für Psychiatrie und Psychotherapie
1996-2021
University of Vienna
1995-2019
University of Massachusetts Amherst
2010-2013
Bayer (Germany)
2011
Bowling Green State University
2009-2010
In treatment-resistant depression, commonly defined as a lack of response to two or more consecutive treatments during the current depressive episode, percentage patients with remission is low and relapse high. The efficacy safety esketamine nasal spray compared extended-release quetiapine augmentation therapy, both in combination ongoing treatment selective serotonin reuptake inhibitor (SSRI) serotonin–norepinephrine (SNRI), depression are unknown. Download PDF Research Summary. an...
Electroconvulsive therapy (ECT) is a potent in severe treatment-refractory depression. Although commonly applied psychiatric clinical routine since decades, the exact neurobiological mechanism regarding its efficacy remains unclear. Results from preclinical and studies emphasize crucial involvement of serotonin-1A receptor (5-HT1A) mode action antidepressant treatment. This includes associations between treatment response changes 5-HT1A function density by antidepressants. Further,...
Background Electroconvulsive therapy (ECT) is the treatment of choice for severe mental illness including treatment-resistant depression (TRD). Increases in volume hippocampus and amygdala following ECT have consistently been reported. Aims To investigate neuroplastic changes after specific hippocampal subfields nuclei using high-resolution structural magnetic resonance imaging (MRI) (trial registration: clinicaltrials.gov – NCT02379767). Method MRI scans were carried out 14 patients (11...
Journal Article High-Frequency Audiometric Monitoring for Early Detection of Aminoglycoside Ototoxicity Get access Stephen A. Fausti, Fausti Search other works by this author on: Oxford Academic PubMed Google Scholar James Henry, Henry Heidi I. Schaffer, Schaffer Deanna J. Olson, Olson Richard H. Frey, Frey Walter McDonald The Infectious Diseases, Volume 165, Issue 6, June 1992, Pages 1026–1032, https://doi.org/10.1093/infdis/165.6.1026 Published: 01 1992 history Received: 28 October 1991...
This study compared metabolic differences in the frontal brain of depressed patients versus age- and sex-matched controls using proton magnetic resonance spectroscopy absolute quantification metabolites (NAA, Cr, Cho, mI) at 3 Tesla.Short-echo-time stimulated echo acquisition mode (TE/TM/TR=20/30/6000 milliseconds) was applied prefrontal region 17 controls. Metabolic ratios, ie, N-acetyl-aspartate/creatine (Cr), choline/Cr, myo-inositol/Cr, concentrations (using internal water as a reference...
Background Cannabinoid-induced analgesia was shown in animal studies of acute inflammatory and neuropathic pain. In humans, controlled clinical trials with Delta-tetrahydrocannabinol or other cannabinoids demonstrated analgesic efficacy chronic pain syndromes, whereas the data were less conclusive. Therefore, aim this study to investigate effects oral cannabis extract two different human models hyperalgesia. Methods The authors conducted a double-blind, crossover 18 healthy female...
A system for the measurement of auditory function from 8000--20 000 Hz is described. This introduces advances in: (a) maximum power output, (b) signal fidelity, and (c) transducer characteristics. Two case studies are presented to illustrate clinical information gained high-frequency sensitivity, which not readily apparent in conventional threshold assessment.
Objective The aim of this study was to identify auditory frequencies at which serial threshold testing would provide the greatest sensitivity for early detection ototoxicity. overall objective is develop a more time-efficient ototoxicity monitoring protocol. Design Threshold data were analyzed from 370 hospitalized patients treated with aminoglycoside antibiotics (AMGs) or cisplatin (CDDP) who received before, during, and after treatment conventional (0.25 8 kHz) high (9 20 frequencies....
Objective and subjective sleep awakening quality as well daytime vigilance of insomniac patients with generalized anxiety disorder (GAD) were investigated, compared normal controls. Forty-four outpatients (25 females, 19 males), aged 24-65 (mean 43) years, diagnosed non-organic insomnia (ICD-10: F 51.0), related to mild GAD (F 41.1), a Hamilton (HAMA) score 22 +/- 6 Zung self-rating (SAS) 37 included. After 1 adaptation night, induction, maintainance architecture measured objectively by...
A recently developed high frequency auditory measurement technique was applied to a sample of patients receiving the antineoplastic agent cis-dichlorodiammineplatinum II (cisplatin [CDDP, DDP]). Ototoxicity as result cisplatin administration is well documented. The ability detect ototoxicity, however, varies with methods and instrumentation utilized, criteria by which ototoxicity defined. function subjects for genitourinary tumors head neck cancers serially monitored conventional audiometry...
High-frequency (8 to 20 kHz) hearing sensitivity was compared in thirty-six, 29-year-old military veterans with histories of steady-state or impulsive noise exposure. Threshold shifts were prominent for the subjects from 13 kHz. Mean thresholds 8 through 12 kHz maximally dB poorer than a sample young adult normals. Audiometric configurations this group generally smooth and symmetrical above 8000 Hz. For group, substantial seen 2 high-frequency audiometric often jagged and/or asymmetrical....
Paroxetine is a novel antidepressant drug with selective serotonin (5-HT) reuptake inhibitory properties. In double-blind placebo-controlled crossover sleep laboratory study the single-dose effects on objective and subjective awakening qualities were investigated after paroxetine 20, 30 40 mg morning doses (PX 30, 40), evening dose, fluoxetine dose (FX 40) placebo in 18 healthy young volunteers. The drugs orally administered 2-wk intervals. addition to each night, adaptation night washout...
Increases in the volume of amygdala and hippocampus after electroconvulsive therapy (ECT) are among most robust effects known to brain-imaging field. Recent advances segmentation substructures these regions allow for novel insights on relationship between brain structure clinical outcomes ECT.We aimed provide a comprehensive synthesis evidence available changes ECT, including recently published data hippocampal subfields.A meta-analysis studies was carried out using random-effects models...