A5065762371- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Salivary Gland Disorders and Functions
- Galectins and Cancer Biology
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Diabetes and associated disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Ocular Surface and Contact Lens
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Toxoplasma gondii Research Studies
Memorial Sloan Kettering Cancer Center
2020-2023
Feinstein Institute for Medical Research
2011-2016
Northwell Health
2013
BACKGROUND. Refractory CMV viremia and disease are associated with significant morbidity mortality in recipients of hematopoietic stem cell transplant (HCT).
Abstract Streptococcus pneumoniae is the most common cause of pneumonia, which claims lives people over age 65 y seven times more frequently than those aged 5–49 y. B-1a cells provide immediate and essential protection from S. through production natural Ig, has minimal insertion N-region additions added by enzyme TdT. In experiments with SCID mice infected pneumoniae, we found passive transfer IgG-depleted serum (18–24 mo old) had no effect whereas young (3 was protective. This suggests...
Abstract Natural Abs produced by B-1a cells are required for immediate protection against infection. The protective capacity of natural is attributed to germline-like structure, which includes the relative absence N-region addition. Previous studies have shown cell Ig from aged mice contains abundant nontemplated (N)-additions. been derive a specific lineage-negative (Lin−)CD45Rlow/−CD19+ progenitor found both in fetal liver and adult bone marrow. In this study, we report identification...
B-1a cells constitutively secrete natural antibody that provides immediate protection against microbial pathogens and functions homeostatically to speed removal of apoptotic cell debris. Although are especially prominent in the peritoneal pleural cavities, some reside spleen. A small subset splenic naïve, unimmunized mice express CD138, a recognized plasma antigen, whereas bulk CD138 negative. Splenic toto have been shown generate much more per than cells; however, specific functional...
B1 B cells defend against infectious microorganisms by spontaneous secretion of broadly reactive "natural" immunoglobulin that appears in the absence immunization. Among many distinguishing characteristics, display evidence activation includes phosphorylated STAT3. In order to identify origin pSTAT3 we examined interleukin-2 receptor (IL-2R) expression on cells. We found some (about 1/5) B1a express IL-2R α chain, CD25. Although lacking CD122 and unresponsive IL-2, marked CD25 increased...
Abstract This study tested the hypothesis that B cells from salivary tissue are distinct in terms of proliferative capacity, immunoglobulin M secretion, repertoire, and autoantibody enrichment Sjögren’s syndrome. We sorted purified spleen, cervical lymph nodes, submandibular glands a primary syndrome mouse model (Id3−/−). Enzyme-linked immunospot proliferation assays were performed with stimulated cells. single-cell gland mice sequenced heavy-chain variable regions. Finally, autoantigen...
Abstract B-1a cells arise predominately during fetal development, and their persistence throughout adult life is maintained through self-renewal. These are essential for immediate protection from S. pneumoniae infection. The unique ability of derived to provide against attributed spontaneously secreted natural IgM, which germline-like due minimal insertion N-region additions little somatic hypermutation. cell pool also by B-1 progenitors found in the bone marrow. We reported these marrow...